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Diabetologia
Published in: Diabetologia 1/2007

01-01-2007 | Commentary

TCF7L2 and type 2 diabetes—we WNT to know

Author: U. Smith

Published in: Diabetologia | Issue 1/2007

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Excerpt

The initial report by Grant et al. [1] that variants in the TCF7L2 gene are strongly associated with risk of developing type 2 diabetes has now been robustly reproduced in many other populations. In fact, variants in this gene contribute more powerfully to the risk of developing type 2 diabetes than any other gene identified to date (see also [2]). …
Literature
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Grant SF, Thorleifsson G, Reynisdottir I et al (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320–323PubMedCrossRef
2.
3.
Damcott CM, Pollin TI, Reinhart LJ et al (2006) Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 55:2654–2659PubMedCrossRef
4.
Polakis P (2000) Wnt signaling and cancer. Genes Dev 14:1837–1851PubMed
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Boyden LM, Mao J, Belsky J et al (2002) High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 346:1513–1521PubMedCrossRef
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Etheridge SL, Spencer GJ, Heath DJ, Genever PG (2004) Expression profiling and functional analysis of Wnt signaling mechanisms in mesenchymal stem cells. Stem Cells 22:849–860PubMedCrossRef
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Ross SE, Hemati N, Longo KA et al (2000) Inhibition of adipogenesis by Wnt signaling. Science 289:950–953PubMedCrossRef
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Papadopoulou S, Edlund H (2005) Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 54:2844–2851PubMed
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Horikawa Y, Oda N, Cox NJ et al (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26:163–175PubMedCrossRef
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Benetti R, Copetti T, Dell’Orso S et al (2005) The calpain system is involved in the constitutive regulation of beta-catenin signaling functions. J Biol Chem 280:22070–22080PubMedCrossRef
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Yi F, Brubaker PL, Jin T (2005) TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J Biol Chem 280:1457–1464PubMedCrossRef
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Korinek V, Barker N, Moerer P et al (1998) Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 19:379–383PubMedCrossRef
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Cauchi S, Meyre D, Dina C et al (2006) Transcription factor TCF7L2 genetic study in the French population: Expression in human β-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 55:2903–2908PubMedCrossRef
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Christodoulides C, Scarda A, Granzotto M et al (2006) WNT10B mutations in human obesity. Diabetologia 49:678–684PubMedCrossRef
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Gustafson B, Smith U (2006) Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 281:9507–9516PubMedCrossRef
16.
Kanazawa A, Tsukada S, Sekine A et al (2004) Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes. Am J Hum Genet 75:832–843PubMedCrossRef
Metadata
Title
TCF7L2 and type 2 diabetes—we WNT to know
Author
U. Smith
Publication date
01-01-2007
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 1/2007
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-006-0521-z

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