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Infectious Diseases and Therapy
Published in: Infectious Diseases and Therapy 5/2024

Open Access 13-04-2024 | Joint Infection | Original Research

Fungal Prosthetic Joint Infection: A Case Series and Review of the Literature

Authors: Victoria Starnes, Joan Duggan, Caitlyn Hollingshead

Published in: Infectious Diseases and Therapy | Issue 5/2024

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Abstract

Introduction

Fungal prosthetic joint infections comprise less than 1% of prosthetic joint infections. Thus, little is known regarding optimal management. This study aims to characterize the microbiology, surgical and medical management, and outcomes for these complex infections. The objectives of this study were to assess the impact of surgical approach, antifungal treatment, fungal species, and time to onset of infection from initial surgery on patient outcomes.

Methods

A retrospective record review over 12 years was performed in two health systems that included patients with a deep culture positive for a fungal isolate and the presence of a prosthetic joint. A literature review was performed using the same inclusion criteria. A total of 289 cases were identified and analyzed.

Results

Candida was the most common isolate, and a two-stage revision was the most commonly employed surgical modality. The type of surgical intervention had a statistically significant relationship with outcome (P = 0.022).

Conclusions

Two-stage revision with extended antifungal therapy is preferred in these infections due to higher rates of positive outcomes.
Appendix
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Literature
1.
Hegde V, Stambough JB, Levine BR, Springer BD. Highlights of the 2022 American Joint Replacement Registry annual report. Arthroplast Today. 2023;21: 101137.PubMedPubMedCentralCrossRef
2.
Kurtz SM, Lau E, Schmier J, Ong KL, Zhao K, Parvizi J. Infection burden for hip and knee arthroplasty in the United States. J Arthroplast. 2008;23(7):984–91.CrossRef
3.
Lentino JR. Prosthetic joint infections: bane of orthopedists, challenge for infectious disease specialists. Clin Infect Dis. 2003;36(9):1157–61.PubMedCrossRef
4.
Azzam K, Parvizi J, Jungkind D, Hanssen A, Fehring T, Springer B, Bozic K, Della Valle C, Pulido L, Barrack R. Microbiological, clinical, and surgical features of fungal prosthetic joint infections: a multi-institutional experience. JBJS. 2009;91(Supplement_6):142–9.CrossRef
5.
Gross CE, Della Valle CJ, Rex JC, Traven SA, Durante EC. Fungal periprosthetic joint infection: a review of demographics and management. J Arthroplast. 2021;36(5):1758–64.CrossRef
6.
Gonzalez MR, Bedi ADS, Karczewski D, Lozano-Calderon SA. Treatment and outcomes of fungal prosthetic joint infections: a systematic review of 225 cases. J Arthroplast. 2023;38:2464-2471.e1.CrossRef
7.
Giovanoulis V, Vasiliadis AV, Koutserimpas C, Samonis G, Batailler C, Ferry T, Lustig S. Prosthetic knee joint infection due to Candida lusitaniae: a diagnostic and therapeutic odyssey: a case study. Diagnostics. 2022;12(11):2640.PubMedPubMedCentralCrossRef
8.
Williams BT, Hogan C, Damioli L. Two-stage revision total knee arthroplasty for chronic histoplasma capsulatum prosthetic joint infection: a case report. JBJS Case Connect. 2022;12(3):e22.00155.CrossRef
9.
Koutserimpas C, Naoum S, Alpantaki K, Raptis K, Dretakis K, Vrioni G, Samonis G. Fungal prosthetic joint infection in revised knee arthroplasty: an orthopaedic surgeon’s nightmare. Diagnostics. 2022;12(7):1606.PubMedPubMedCentralCrossRef
10.
Chong YC, Tse TST. A case of Candida parapsilosis periprosthetic joint infection: case report and literature review. J Orthop Trauma Rehabil. 2022;29(1):22104917221075824.
11.
Shah S, Haq S, Antony SJ. Coccidioidomycosis resulting in a prosthetic joint infection in an immunocompetent patient after a total hip arthroplasty: a case report and review of the literature. Infect Disord Drug Targets. 2022;22(2): e170322188282.PubMedCrossRef
12.
Lin Y-J, Su T, Yang L, Chen G-X. Mixed bacterial-fungal infection following total hip arthroplasty: a case report. Chin J Traumatol. 2022;25(01):32–6.PubMedCrossRef
13.
Bottagisio M, Bidossi A, Logoluso N, Pellegrini A, De Vecchi E. A spacer infection by Candida albicans secondary to a Staphylococcus capitis prosthetic joint infection: a case report. BMC Infect Dis. 2021;21(1):416.PubMedPubMedCentralCrossRef
14.
Morimoto Y, Yo H, Ohashi H. Two-stage revision using antifungal-loaded cement beads for the treatment of Candida infection following revision total hip arthroplasty: a case report. J Orthop Sci. 2021;26(3):505–9.PubMedCrossRef
15.
Kurmis AP. Eradicating fungal periprosthetic TKA “super-infection”: review of the contemporary literature and consideration of antibiotic-impregnated dissolving calcium sulfate beads as a novel PJI treatment adjunct. Arthroplast Today. 2021;8:163–70.PubMedPubMedCentralCrossRef
16.
Berbari HE, Gurram P, Mahmood M, Deziel PJ, Walker RC, Razonable RR. Prosthetic joint infections due to histoplasma capsulatum: a report of 3 cases. Mayo Clin Proc Innov Qual Outcomes. 2021;5(1):225–9.PubMedPubMedCentralCrossRef
17.
George JC, Sainulabdeen J, Chittaranjan S, George K, Babu S. Single-stage revision with fluconazole monotherapy in fungal prosthetic knee joint infections. Arthroplast Today. 2021;7:238–41.PubMedPubMedCentralCrossRef
18.
19.
Ciochetto Z, Georgen M, Hadro A, Jurkowski L, Ridolfi K, Wooldridge A, Gundacker N, Haque J. Reactivation of Coccidioides immitisi in a prosthetic knee after initiation of chemotherapy. Case Rep Hematol. 2021;2021:3964465.PubMedPubMedCentral
20.
Oenning S, Moellenbeck B, Gosheger G, Schmidt-Bräkling T, Schwarze J, Ackmann T, Schneider KN, Theil C. Fungal periprosthetic knee joint infection in a patient with metamizole-induced agranulocytosis. Arthroplast Today. 2020;6(4):726–30.PubMedPubMedCentralCrossRef
21.
Frieler S, Yilmaz E, Goodmanson R, Hanusrichter Y, Schildhauer TA, Baecker H. Conversion from knee arthrodesis back to arthroplasty: a particular challenge in combination with fungal periprosthetic joint infection. Arthroplast Today. 2020;6(4):1038–44.PubMedPubMedCentralCrossRef
22.
Xin J, Guo QS, Zhang HY, Zhang ZY, Talmy T, Han YZ, Xie Y, Zhong Q, Zhou SR, Li Y. Candidal periprosthetic joint infection after primary total knee arthroplasty combined with ipsilateral intertrochanteric fracture: a case report. World J Clin Cases. 2020;8(21):5401–8.PubMedPubMedCentralCrossRef
23.
Saconi ES, de Carvalho VC, de Oliveira PRD, Lima A. Prosthetic joint infection due to Candida species: case series and review of literature. Medicine (Baltimore). 2020;99(15): e19735.PubMedCrossRef
24.
Vergison L, Schepens A, Liekens K, De Kesel R, Van der Bracht H, Victor J. Periprosthetic joint infection of a total hip arthroplasty with Candida parapsilosis. Int J Surg Case Rep. 2020;69:72–5.PubMedPubMedCentralCrossRef
25.
Murata Y, Okabe S, Tamagawa S, Ohnishi H, Sakai A. Candidal prosthetic hip infection in a patient with previous candidal sepsis—a case report. J UOEH. 2020;42(4):327–30.PubMedCrossRef
26.
Bini Viotti J, Corzo-Pedroza M, Gonzales Zamora JA. Prosthetic joint infection caused by Candida lusitaniae: report of a unique case. Acta Clin Belg. 2019;74(4):286–91.PubMedCrossRef
27.
Meiyappan A, Villa JM, Sabesan VJ, Patel PD, Suarez JC. Histoplasma capsulatum periprosthetic knee infection complicated by autoimmune-mediated systemic inflammatory response syndrome. Arthroplast Today. 2019;5(2):135–8.PubMedPubMedCentralCrossRef
28.
Pasticci MB, Papalini C, Leli A, Bruno G. Two-stage revision and systemic antifungal therapy of Candida glabrata primary prosthetic hip infection successfully treated: a case report. J Med Case Rep. 2019;13(1):151.PubMedPubMedCentralCrossRef
29.
Kuner E, Jöckel JA, Orler R, Nüesch R. Periprosthetic knee infection by Mycobacterium bovis and Candida guilliermondii in the context of a zoonosis: a case report and review of the literature. J Med Case Reports. 2019;13(1):54.CrossRef
30.
Lee YR, Kim HJ, Lee EJ, Sohn JW, Kim MJ, Yoon YK. Prosthetic joint infections caused by Candida species: a systematic review and a case series. Mycopathologia. 2019;184(1):23–33.PubMedCrossRef
31.
Gao Z, Li X, Du Y, Peng Y, Wu W, Zhou Y. Success rate of fungal peri-prosthetic joint infection treated by 2-stage revision and potential risk factors of treatment failure: a retrospective study. Med Sci Monit. 2018;24:5549–57.PubMedPubMedCentralCrossRef
32.
Xiang Y, Xuan YY, Li G. Successful treatment for acute prosthetic joint infection due to MRSA and Candida albicans: a case report and literature review. Ther Clin Risk Manag. 2018;14:1133–9.PubMedPubMedCentralCrossRef
33.
Sebastian S, Malhotra R, Pande A, Gautam D, Xess I, Dhawan B. Staged reimplantation of a total hip prosthesis after co-infection with Candida tropicalis and Staphylococcus haemolyticus: a case report. Mycopathologia. 2018;183(3):579–84.PubMedCrossRef
34.
Koutserimpas C, Samonis G, Velivassakis E, Iliopoulou-Kosmadaki S, Kontakis G, Kofteridis DP. Candida glabrata prosthetic joint infection, successfully treated with anidulafungin: a case report and review of the literature. Mycoses. 2018;61(4):266–9.PubMedCrossRef
35.
Burgo FJ, Mengelle DE, Abraham A, Kremer G, Autorino CM. Periprosthetic fungal infection of a hip caused by Trichosporon inkin. Arthroplast Today. 2018;4(1):24–6.PubMedCrossRef
36.
Bartash R, Guo Y, Pope JB, Levi MH, Szymczak W, Saraiya N, Nori P. Periprosthetic hip joint infection with Aspergillus terreus: a clinical case and a review of the literature. Med Mycol Case Rep. 2017;18:24–7.PubMedPubMedCentralCrossRef
37.
Carrega G, Cavagnaro L, Basso M, Riccio G, Ronca A, Salomone C, Burastero G. Azole-resistant Candida albicans prosthetic joint infection treated with prolonged administration of anidulafungin and two-stage exchange with implant of a mega-prosthesis. J Chemother. 2017;29(6):386–8.PubMedCrossRef
38.
39.
Cooper LG, Heydemann J, Misenhimer G, Antony S. Use of intra-articular amphotericin b in the treatment of Candida parasilosis and albicans in prosthetic joint infections (PJI): a novel approach to this difficult problem. Infect Disord Drug Targets. 2017;17(1):36–42.PubMedCrossRef
40.
Cobo F, Rodríguez-Granger J, López EM, Jiménez G, Sampedro A, Aliaga-Martínez L, Navarro-Marí JM. Candida-induced prosthetic joint infection. A literature review including 72 cases and a case report. Infect Dis (Lond). 2017;49(2):81–94.PubMedCrossRef
41.
Domínguez DC, Camacho E, Antony S. The role of molecular technology and prolonged cultures in the diagnosis of fungal prosthetic joint infections and orthopedic-related devices. Infect Dis Clin Pract. 2016;24(5):e35–6.CrossRef
42.
Geng L, Xu M, Yu L, Li J, Zhou Y, Wang Y, Chen J. Risk factors and the clinical and surgical features of fungal prosthetic joint infections: a retrospective analysis of eight cases. Exp Ther Med. 2016;12(2):991–9.PubMedPubMedCentralCrossRef
43.
Jenny JY, Goukodadja O, Boeri C, Gaudias J. May one-stage exchange for Candida albicans peri-prosthetic infection be successful? Orthop Traumatol Surg Res. 2016;102(1):127–9.PubMedCrossRef
44.
Arbeloa-Gutierrez L, Kuberski T, Johnson SM, Sagastibelza I, Alaez JI, Pappagianis D. Reactivation of coccidioidomycosis: a prosthetic joint infection in Spain. Eur J Clin Microbiol Infect Dis. 2016;35(2):183–6.PubMedCrossRef
45.
Wang QJ, Shen H, Zhang XL, Jiang Y, Wang Q, Chen YS, Shao JJ. Staged reimplantation for the treatment of fungal peri-prosthetic joint infection following primary total knee arthroplasty. Orthop Traumatol Surg Res. 2015;101(2):151–6.PubMedCrossRef
46.
Shah NB, Shoham S, Nayak S. Cryptococcus neoformans prosthetic joint infection: case report and review of the literature. Mycopathologia. 2015;179(3):275–8.PubMedCrossRef
47.
Zhu Y, Yue C, Huang Z, Pei F. Candida glabrata infection following total hip arthroplasty: a case report. Exp Ther Med. 2014;7(2):352–4.PubMedCrossRef
48.
Klatte TO, Kendoff D, Kamath AF, Jonen V, Rueger JM, Frommelt L, Gebauer M, Gehrke T. Single-stage revision for fungal peri-prosthetic joint infection: a single-centre experience. Bone Jt J. 2014;96-B(4):492–6.CrossRef
49.
Presman B, Christensen JJ, Broeng L, Marckmann P, Nielsen XC. Deep infection with Candida albicans following total hip replacement: two case reports. Infect Dis Clin Pract. 2014;22(4):e72–3.CrossRef
50.
Lidder S, Tasleem A, Masterson S, Carrington R. Candida tropicalis: diagnostic dilemmas for an unusual prosthetic hip infection. J R Army Med Corps. 2013;159:123–5.PubMedCrossRef
51.
Villamil-Cajoto I, Eynde-Collado A, Otero L, Vicedo MV. Personal autonomy in the management of candidal prosthetic joint infection. Open Med. 2012;7(4):539–41.CrossRef
52.
MacGregor RR, Schimmer BM, Steinberg ME. Results of combined amphotericin B-5-fluorcytosine therapy for prosthetic knee joint infected with Candida parapsilosis. J Rheumatol. 1979;6(4):451–5.PubMed
53.
Lichtman EA. Candida infection of a prosthetic shoulder joint. Skelet Radiol. 1983;10(3):176–7.CrossRef
54.
Younkin S, Evarts CM, Steigbigel RT. Candida parapsilosis infection of a total hip-joint replacement: successful reimplantation after treatment with amphotericin B and 5-fluorocytosine. A case report. JBJS. 1984;66(1):142–3.CrossRef
55.
Lim EV, Stern PJ. Candida infection after implant arthroplasty. A case report. JBJS. 1986;68(1):143–5.CrossRef
56.
Rabin OD, Richard JH, Daniel MM, Young EJ, Harris RL. Periprosthetic candidal infections following arthroplasty. Rev Infect Dis. 1989;11(1):89–96.CrossRef
57.
Chiu W-K, Chung K-Y, Cheung K-W, Chiu K-H. Candida parapsilosis total hip arthroplasty infection: case report and literature review. J Orthop Trauma Rehabil. 2013;17(1):33–6.
58.
Deelstra JJ, Neut D, Jutte PC. Successful treatment of Candida albicans-infected total hip prosthesis with staged procedure using an antifungal-loaded cement spacer. J Arthroplast. 2013;28(2):374.e375-374.e378.CrossRef
59.
Austen S, van der Weegen W, Verduin CM, van der Valk M, Hoekstra HJ. Coccidioidomycosis infection of a total knee arthroplasty in a nonendemic region. J Arthroplast. 2013;28(2):375.e313-375.e315.CrossRef
60.
61.
Anagnostakos K, Kelm J, Schmitt E, Jung J. Fungal periprosthetic hip and knee joint infections: clinical experience with a 2-stage treatment protocol. J Arthroplast. 2012;27(2):293–8.CrossRef
62.
Springer J, Chatterjee S. Candida albicans prosthetic shoulder joint infection in a patient with rheumatoid arthritis on multidrug therapy. JCR J Clin Rheumatol. 2012;18(1):52–3.PubMedCrossRef
63.
Lackner M, De Man FH, Eygendaal D, Wintermans RGF, Kluytmans JA, Klaassen CH, Meis JF. Severe prosthetic joint infection in an immunocompetent male patient due to a therapy refractory Pseudallescheria apiosperma. Mycoses. 2011;54(s3):22–7.PubMedCrossRef
64.
Gottesman-Yekutieli T, Dan M, Shwartz O, Edelman A, Hendel D. Pseudallescheria boydii infection of a prosthetic hip joint—an uncommon infection in a rare location. Am J Med Sci. 2011;342(3):250–3.PubMedCrossRef
65.
Wu M-H, Hsu K-Y. Candidal arthritis in revision knee arthroplasty successfully treated with sequential parenteral-oral fluconazole and amphotericin B-loaded cement spacer. Knee Surg Sports Traumatol Arthrosc. 2011;19(2):273–6.PubMedCrossRef
66.
Graw B, Woolson S, Huddleston JI. Candida infection in total knee arthroplasty with successful reimplantation. J Knee Surg. 2010;23(3):169–74.PubMedCrossRef
67.
Johannsson B, Callaghan JJ. Prosthetic hip infection due to Cryptococcus neoformans: case report. Diagn Microbiol Infect Dis. 2009;64(1):76–9.PubMedCrossRef
68.
Bland CM, Thomas S. Micafungin plus fluconazole in an infected knee with retained hardware due to Candida albicans. Ann Pharmacother. 2009;43(3):528–31.PubMedCrossRef
69.
Fabry K, Verheyden F, Nelen G. Infection of a total knee prosthesis by Candida glabrata: a case report. Acta Orthop Belg. 2005;71(1):119–21.PubMed
70.
Lerch K, Kalteis T, Schubert T, Lehn N, Grifka J. Prosthetic joint infections with osteomyelitis due to Candida albicans. Mycoses. 2003;46(11–12):462–6.PubMedCrossRef
71.
Açikgöz ZC, Sayli U, Avci S, Doğruel H, Gamberzade S. An extremely uncommon infection: Candida glabrata arthritis after total knee arthroplasty. Scand J Infect Dis. 2002;34(5):394–6.PubMedCrossRef
72.
David MP, Douglas RO, Michael RK, Arlen DH. Delayed reimplantation arthroplasty for candidal prosthetic joint infection: a report of 4 cases and review of the literature. Clin Infect Dis. 2002;34(7):930–8.CrossRef
73.
Cutrona AF, Shah M, Himes MS, Miladore MA. Rhodotorula minuta: an unusual fungal infection in hip-joint prosthesis. Am J Orthop (Belle Mead NJ). 2002;31(3):137–40.PubMed
74.
Merrer J, Dupont B, Nieszkowska A, De Jonghe B, Outin H. Candida albicans prosthetic arthritis treated with fluconazole alone. J Infect. 2001;42(3):208–9.PubMedCrossRef
75.
Yang S-H, Pao J-L, Hang Y-S. Staged reimplantation of total knee arthroplasty after Candida infection. J Arthroplast. 2001;16(4):529–32.CrossRef
76.
Wada M, Baba H, Imura S. Prosthetic knee Candida parapsilosis infection. J Arthroplast. 1998;13(4):479–82.CrossRef
77.
Fowler VG Jr, Nacinovich FM, Alspaugh JA, Corey GR. Prosthetic joint infection due to Histoplasma capsulatum: case report and review. Clin Infect Dis. 1998;26(4):1017.PubMedCrossRef
78.
Nayeri F, Cameron R, Chryssanthou E, Johansson L, Söderström C. Candida glabrata prosthesis infection following pyelonephritis and septicaemia. Scand J Infect Dis. 1997;29(6):635–8.PubMedCrossRef
79.
Cardinal E, Braunstein EM, Capello WN, Heck DA. Candida albicans infection of prosthetic joints. Orthopedics. 1996;19(3):247–51.PubMedCrossRef
80.
Hirsch BE, Farber BF, Shapiro JF, Kennelly S. Successful treatment of Aureobasidium pullulans prosthetic hip infection. Infect Dis Clin Pract. 1996;5(3):205–6.CrossRef
81.
Evans RP, Nelson CL. Staged reimplantation of a total hip prosthesis after infection with Candida albicans. A report of two cases. JBJS. 1990;72(10):1551–3.CrossRef
82.
Dutronc H, Dauchy FA, Cazanave C, Rougie C, Lafarie-Castet S, Couprie B, Fabre T, Dupon M. Candida prosthetic infections: case series and literature review. Scand J Infect Dis. 2010;42(11–12):890–5.PubMedCrossRef
83.
Goodman JS, Seibert DG, Reahl GE Jr, Geckler RW. Fungal infection of prosthetic joints: a report of two cases. J Rheumatol. 1983;10(3):494–5.PubMed
84.
Koch AE. Candida albicans infection of a prosthetic knee replacement: a report and review of the literature. J Rheumatol. 1988;15(2):362–5.PubMed
85.
Iskander MK, Khan MA. Candida albicans infection of a prosthetic knee replacement. J Rheumatol. 1988;15(10):1594–5.PubMed
86.
Levine M, Rehm SJ, Wilde AH. Infection with Candida albicans of a total knee arthroplasty: case report and review of the literature. Clin Orthop Relat Res. 1988;226:235–9.CrossRef
87.
Mark L, David T, Matthew Bidwell G. Fungal prosthetic arthritis: presentation of two cases and review of the literature. Rev Infect Dis. 1988;10(5):1038–43.CrossRef
88.
Paul J, White SH, Nicholls KM, Crook DW. Prosthetic joint infection due to Candida parapsilosis in the UK: case report and literature review. Eur J Clin Microbiol Infect Dis. 1992;11(9):847–9.PubMedCrossRef
89.
Austin KS, Testa NN, Luntz RK, Greene JB, Smiles S. Aspergillus infection of total knee arthroplasty presenting as a popliteal cyst: Case report and review of the literature. J Arthroplasty. 1992;7(3):311–4.PubMedCrossRef
90.
Tunkel AR, Thomas CY, Wispelwey B. Candida prosthetic arthritis: report of a case treated with fluconazole and review of the literature. Am J Med. 1993;94(1):100–3.PubMedCrossRef
91.
White A, Goetz MB. Candida parapsilosis prosthetic joint infection unresponsive to treatment with fluconazole. Clin Infect Dis. 1995;20(4):1068–9.PubMedCrossRef
92.
Hennessy MJ. Infection of a total knee arthroplasty by Candida parapsilosis. A case report of successful treatment by joint reimplantation with a literature review. Am J Knee Surg. 1996;9(3):133–6.PubMed
93.
Cushing RD, Fulgenzi WR. Synovial fluid levels of fluconazole in a patient with Candida parapsilosis prosthetic joint infection who had an excellent clinical response. J Arthroplasty. 1997;12(8):950.PubMedCrossRef
94.
Fukasawa N, Shirakura K. Candida arthritis after total knee arthroplasty—a case of successful treatment without prosthesis removal. Acta Orthop Scand. 1997;68(3):306–7.PubMedCrossRef
95.
Simonian PT, Brause BD, Wickiewicz TL. Candida infection after total knee arthroplasty. Management without resection or amphotericin B. J Arthroplasty. 1997;12(7):825–9.PubMedCrossRef
96.
Selmon GPF, Slater RNS, Shepperd JAN, Wright EP. Successful 1-stage exchange total knee arthroplasty for fungal infection. J Arthroplast. 1998;13(1):114–5.CrossRef
97.
Brooks DH, Pupparo F. Successful salvage of a primary total knee arthroplasty infected with Candida parapsilosis. J Arthroplast. 1998;13(6):707–12.CrossRef
98.
Baumann PA, Cunningham B, Patel NS, Finn HA. Aspergillus fumigatus infection in a mega prosthetic total knee arthroplasty: salvage by staged reimplantation with 5-year follow-up. J Arthroplast. 2001;16(4):498–503.CrossRef
99.
Ramamohan N, Zeineh N, Grigoris P, Butcher I. Candida glabrata infection after total hip arthroplasty. J Infect. 2001;42(1):74–6.PubMedCrossRef
100.
Marra F, Robbins GM, Masri BA, Duncan C, Wasan KM, Kwong EH, Jewesson PJ. Amphotericin B-loaded bone cement to treat osteomyelitis caused by Candida albicans. Can J Surg. 2001;44(5):383–6.PubMedPubMedCentral
101.
Wyman J, McGough R, Limbird R. Fungal infection of a total knee prosthesis: successful treatment using articulating cement spacers and staged reimplantation. Orthopedics. 2002;25(12):1391–4 (discussion 1394).PubMedCrossRef
102.
Langer P, Kassim RA, Macari GS, Saleh KJ. Aspergillus infection after total knee arthroplasty. Am J Orthop (Belle Mead NJ). 2003;32(8):402–4.PubMed
103.
Lazzarini L, Manfrin V, de Lalla F. Candidal prosthetic hip infection in a patient with previous candidal septic arthritis. J Arthroplast. 2004;19(2):248–52.CrossRef
104.
Gaston G, Ogden J. Candida glabrata periprosthetic infection: a case report and literature review. J Arthroplast. 2004;19(7):927–30.CrossRef
105.
Baecker H, Frieler S, Geßmann J, Pauly S, Schildhauer TA, Hanusrichter Y. Three-stage revision arthroplasty for the treatment of fungal periprosthetic joint infection: outcome analysis of a novel treatment algorithm. Bone Jt Open. 2021;2(8):671–8.PubMedPubMedCentralCrossRef
106.
Ueng SWN, Lee C-Y, Hu C-C, Hsieh P-H, Chang Y. What is the success of treatment of hip and knee candidal periprosthetic joint infection? Clin Orthop Relat Res. 2013;471(9):3002–9.PubMedPubMedCentralCrossRef
107.
Ji B, Zhang X, Xu B, Guo W, Mu W, Cao L. Single-stage revision for chronic fungal periprosthetic joint infection: an average of 5 years of follow-up. J Arthroplast. 2017;32(8):2523–30.CrossRef
108.
Kim J-K, Lee D-Y, Kang D-W, Ro D-H, Lee MC, Han H-S. Efficacy of antifungal-impregnated cement spacer against chronic fungal periprosthetic joint infections after total knee arthroplasty. Knee. 2018;25(4):631–7.PubMedCrossRef
109.
Brown TS, Petis SM, Osmon DR, Mabry TM, Berry DJ, Hanssen AD, Abdel MP. Periprosthetic joint infection with fungal pathogens. J Arthroplast. 2018;33(8):2605–12.CrossRef
110.
Bruce AS, Kerry RM, Norman P, Stockley I. Fluconazole-impregnated beads in the management of fungal infection of prosthetic joints. J Bone Jt Surg Br. 2001;83(2):183–4.CrossRef
111.
Bartalesi F, Fallani S, Salomoni E, Marcucci M, Meli M, Pecile P, Cassetta MI, Latella L, Bartoloni A, Novelli A. Candida glabrata prosthetic hip infection. Am J Orthop (Belle Mead NJ). 2012;41(11):500–5.PubMed
112.
Dumaine V, Eyrolle L, Baixench MT, Paugam A, Larousserie F, Padoin C, Tod M, Salmon D. Successful treatment of prosthetic knee Candida glabrata infection with caspofungin combined with flucytosine. Int J Antimicrob Agents. 2008;31(4):398–9.PubMedCrossRef
113.
Lejko-Zupanc T, Mozina E, Vrevc F. Caspofungin as treatment for Candida glabrata hip infection. Int J Antimicrob Agents. 2005;25(3):273–4.PubMedCrossRef
114.
Darouiche RO, Hamill RJ, Musher DM, Young EJ, Harris RL. Periprosthetic candidal infections following arthroplasty. Rev Infect Dis. 1989;11(1):89–96.PubMedCrossRef
115.
Antony S, Domínguez DC, Jackson J, Misenheimer G. Evaluation and treatment of Candida species in prosthetic joint infections: two case reports and review of the literature. Infect Dis Clin Pract. 2008;16(6):354–9.CrossRef
116.
117.
Azam A, Singh P, Singh V, Siddiqui A. A rare case of Candida tropicalis infection of a total hip arthroplasty: a case report and review of literature. Malays Orthop Jo. 2008;2(2):43–6.CrossRef
118.
Kuo F-C, Goswami K, Shohat N, Blevins K, Rondon AJ, Parvizi J. Two-stage exchange arthroplasty is a favorable treatment option upon diagnosis of a fungal periprosthetic joint infection. J Arthroplast. 2018;33(11):3555–60.CrossRef
119.
Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med. 2004;351(16):1645–54.PubMedCrossRef
120.
Cordero-Ampuero J. Girdlestone procedure: when and why. HIP Int. 2012;22(8_suppl):36–9.CrossRef
121.
Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, et al. Clinical practice guideline for the management of Candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2015;62(4):e1–50.PubMedPubMedCentralCrossRef
Metadata
Title
Fungal Prosthetic Joint Infection: A Case Series and Review of the Literature
Authors
Victoria Starnes
Joan Duggan
Caitlyn Hollingshead
Publication date
13-04-2024
Publisher
Springer Healthcare
Published in
Infectious Diseases and Therapy / Issue 5/2024
Print ISSN: 2193-8229
Electronic ISSN: 2193-6382
DOI
https://doi.org/10.1007/s40121-024-00964-9

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