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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Oral presentation

Lersivirine: a new NNRTI active across HIV-1 subtypes with a unique resistance profile

Authors: J Mori, M Westby, M Tawadrous, E van der Ryst, C Charles

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

Lersivirine (UK-453,051), a new potent NNRTI, displays novel binding with a unique in vitro resistance profile, and shows potential for use against transmitted NNRTI resistant virus and as a candidate for sequential NNRTI therapy. Further in vitro analyses have been performed to establish the breadth of activity and identify potential populations that might benefit from lersivirine therapy. Lersivirine activity against various HIV-1 subtypes and viruses with decreased susceptibility to etravirine (ETR) were characterised. …
Metadata
Title
Lersivirine: a new NNRTI active across HIV-1 subtypes with a unique resistance profile
Authors
J Mori
M Westby
M Tawadrous
E van der Ryst
C Charles
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-O49

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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