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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Poster presentation

Intracellular tenofovir-diphosphate accumulation in an HIV-infected patient with Fanconi syndrome and osteomalacia

Authors: ME Haverkort, BW van der Spek, PT Lips, WAT Slieker, W Bronsveld

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

We present a patient with tenofovir disoproxil fumarate (TDF)-induced Fanconi syndrome, osteomalacia and concurrent nucleos(t)ide reverse transcriptase inhibitor related CD4 cell decline. Sequentially measured intracellular (ic) tenofovir-diphosphate (TFV-DP) levels were extremely high, with plasma TFV just slightly elevated. …
Literature
1.
Pruvost A, Negredo E, Théodoro F, et al: Pilot pharmacokinetic study of human immunodeficiency virus-infected patients receiving tenofovir disoproxil fumarate (TDF): investigation of systemic and intracellular interactions between TDF and abacavir, lamivudine, or lopinavir-ritonavir. Antimicrob Agents Chemother. 2009, 53: 1937-1943. 10.1128/AAC.01064-08.PubMedCentralCrossRefPubMed
Metadata
Title
Intracellular tenofovir-diphosphate accumulation in an HIV-infected patient with Fanconi syndrome and osteomalacia
Authors
ME Haverkort
BW van der Spek
PT Lips
WAT Slieker
W Bronsveld
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-P87

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