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01-02-2007 | LETTER TO THE EDITORS

Leber’s Hereditary Optic Neuropathy associated with cocaine, ecstasy and telithromycin consumption

Authors: Elena Cardaioli, Paola Da Pozzo, Gian Nicola Gallus, Rossella Franceschini, Alessandra Rufa, Maria Teresa Dotti, Aldo Caporossi, Antonio Federico

Published in: Journal of Neurology | Issue 2/2007

Excerpt

Sirs: Leber’s hereditary optic neuropathy (LHON) is a matrilinear disorder characterised by acute to subacute bilateral optic neuropathy, mostly affecting young males at variable age of onset. More than 90% of patients harbour one of the three pathogenic mitochondrial DNA (mtDNA) mutations: 3,460, 11,778, and 14,484, all in genes encoding subunits of respiratory chain complex I. In most patients visual loss is severe and permanent, though spontaneous recovery of central vision may occur, particularly in patients with the 14,484 mutation. …

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Title: Leber’s Hereditary Optic Neuropathy associated with cocaine, ecstasy and telithromycin consumption
Authors: Elena Cardaioli
Paola Da Pozzo
Gian Nicola Gallus
Rossella Franceschini
Alessandra Rufa
Maria Teresa Dotti
Aldo Caporossi
Antonio Federico
Publication date: 01-02-2007
Publisher: Steinkopff-Verlag
Published in: Journal of Neurology / Issue 2/2007
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-006-0351-4

At a glance: The STEP trials

Springer Medicine

Leber’s Hereditary Optic Neuropathy associated with cocaine, ecstasy and telithromycin consumption

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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