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Open Access 01-02-2007 | LETTER TO THE EDITORS

Warm-up phenomenon in myotonia associated with the V445M sodium channel mutation

Authors: J. Trip, MD, C.G. Faber, MD, PhD, H.B. Ginjaar, PhD, B.G.M. van Engelen, MD, PhD, G. Drost, MD

Published in: Journal of Neurology | Issue 2/2007

Excerpt

Sirs: Myotonia is a clinical phenomenon consisting of uncontrolled temporary muscle stiffness after voluntary or evoked muscle contractions [1]. It is a cardinal symptom in non-dystrophic myotonias, including chloride and sodium channelopathies. Myotonia typically occurs after a period of rest and decreases with continuing exercise, commonly referred to as the warm-up phenomenon. This is in contrast with what occurs in paradoxical myotonia, where muscle stiffness increases as a result of continuing exercise. …

Lehmann-Horn F, Rüdel R, Jurkat-Rott K (2004) Nondystrophic myotonias and periodic sparalysis. In: Engel AG, Franzini-Armstrong C (eds) Myology, 3^rd edn. Mc Graw-Hill, New York, pp 1257–1300

Logigian EL, Blood CL, Dilek N, Martens WB, Moxley RT 4^th, Wiegner AW, Thornton CA, Moxley RT 3^rd (2005) Quantitative analysis of the “warm-up” phenomenon in myotonic dystrophy type 1. Muscle Nerve 32:35–42PubMedCrossRef

Ptacek LJ, Johnson KJ, Griggs RC (1993) Genetics and physiology of the myotonic muscle. N Engl J Med 328:482–9PubMedCrossRef

Rosenfeld J, Sloan-Brown K, George AL Jr (1997) A novel muscle sodium channel mutation causes painful congenital myotonia. Ann Neurol 42:811–814PubMedCrossRef

Vicart S, Sternberg D, Fontaine B, Meola G (2005) Human skeletal muscle sodium channelopathies. Neurol Sci 26:194–202PubMedCrossRef

Title: Warm-up phenomenon in myotonia associated with the V445M sodium channel mutation
Authors: J. Trip, MD
C.G. Faber, MD, PhD
H.B. Ginjaar, PhD
B.G.M. van Engelen, MD, PhD
G. Drost, MD
Publication date: 01-02-2007
Publisher: Steinkopff-Verlag
Published in: Journal of Neurology / Issue 2/2007
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-006-0353-2

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Warm-up phenomenon in myotonia associated with the V445M sodium channel mutation

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