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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2014

Open Access 01-12-2014 | Research article

Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC

Authors: Johanna M Gostner, Markus Ganzera, Kathrin Becker, Simon Geisler, Sebastian Schroecksnadel, Florian Überall, Harald Schennach, Dietmar Fuchs

Published in: BMC Complementary Medicine and Therapies | Issue 1/2014

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Abstract

Background

Lavender remedies have been used in traditional medicine because of antimicrobial, anti-inflammatory and mood alleviating effects, but underlying molecular mechanisms are not yet fully elucidated. Recently, studies investigating the effects of lavender oil in the context of psychiatric disorders have indicated potent pharmacological properties. Metabolism of tryptophan by indoleamine 2,3-dioxygenase (IDO) was found to provide a biochemical link between immunology and neuroendocrinology and to be a frequent target of natural products.

Methods

In this in vitro study, interferences of lavender oil and constituents (-)-linalool, (+)-α-pinene and (+)-limonene with tryptophan catabolism by IDO and formation of neopterin via guanosine triphosphate (GTP)-cyclohydrolase-I and of interferon-γ have been investigated using unstimulated and phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMC).

Results

Treatment with lavender oil dose-dependently suppressed PHA-induced tryptophan breakdown and kynurenine formation. Similar effects were observed for the three constituents. In parallel, formation of neopterin and interferon-γ was diminished upon lavender oil treatment. In unstimulated PBMC, effect of lavender oil treatment was similar, but less pronounced.

Conclusion

Data from this in vitro study suggest that lavender oil treatment might contribute to the modulation of the immune and neuroendocrine system by interfering with activation-induced tryptophan breakdown and IDO activity.
Appendix
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Metadata
Title
Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC
Authors
Johanna M Gostner
Markus Ganzera
Kathrin Becker
Simon Geisler
Sebastian Schroecksnadel
Florian Überall
Harald Schennach
Dietmar Fuchs
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2014
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/1472-6882-14-503

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