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Knee Surgery, Sports Traumatology, Arthroscopy

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Open Access 10-09-2022 | Knee Osteoarthritis | KNEE

Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue

Authors: R. Ferracini, M. Alessio-Mazzola, B. Sonzogni, C. Stambazzi, C. Ursino, I. Roato, F. Mussano, A. Bistolfi, S. Furlan, L. Godio, D. Alotto, M. Formica

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 9/2023

Abstract

Purpose

This study aims to assess the effectiveness of Microfragmented Autologous Fat Tissue (MFAT) treatment for knee osteoarthritis and to investigate whether patients’ pre-treatment clinical condition, such as synovitis, correlates with clinical outcomes, to identify potential predicting factors for the success or failure of the treatment.

Methods

In this prospective Cohort Study Level II multicentric trial, consecutive patients with a diagnosis of early/mild osteoarthritis and failure of previous conservative measures were enrolled to undergo diagnostic arthroscopy and a single MFAT injection. Patients were assessed with repeated scoring systems at baseline, 6 months, and 12 months after surgery. The demographic features, the arthroscopic findings, the immunophenotype of injected tissue and the histologic examination of synovia of failed patients were analyzed.

Results

Data from 91 patients showed a significant improvement in Lysholm, WOMAC scores at 1-year follow-up (p < 0.001). A significant decrease in VAS score was observed, while a significant improvement of measured flexion angle was registered at 1 year (p < 0.001). No major complications were reported.

Age and synovitis were identified as significant factors influencing the clinical outcome (p < 0.05). Body mass index, previous or concomitant procedures, and specific cartilage defects had no influence. The mean number of injected adipose tissue-derived mesenchymal stem cells seem not to correlate with the clinical outcome.

Conclusion

MFAT is effective in reducing pain when used with a single dose injection in early/mild OA of the knee, without major complications. Age over 60 and synovitis may be predictive for persistent pain at one year and should be considered before indications.

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Title: Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue
Authors: R. Ferracini
M. Alessio-Mazzola
B. Sonzogni
C. Stambazzi
C. Ursino
I. Roato
F. Mussano
A. Bistolfi
S. Furlan
L. Godio
D. Alotto
M. Formica
Publication date: 10-09-2022
Publisher: Springer Berlin Heidelberg
Keywords: Knee Osteoarthritis
Osteoarthrosis
Autologous Fat
Osteoarthrosis
Knee Osteoarthritis
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 9/2023
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-022-07139-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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