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BMC Nephrology
Published in: BMC Nephrology 1/2023

Open Access 01-12-2023 | Kidney Transplantation | Case Report

Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature

Authors: Fatma El-Husseiny Moustafa, Eman Nagy, Salwa Mahmoud Elwasif, Mohamed Sobh

Published in: BMC Nephrology | Issue 1/2023

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Abstract

Karyomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving kidneys from 2 different unrelated living donors. A male kidney transplant recipient with focal segmental glomerulosclerosis as the original kidney disease presented with graft impairment and proteinuria, and graft biopsy revealed KIN. This patient had a brother who was also a kidney transplant recipient and had one episode of graft impairment and was diagnosed with KIN as well.
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Metadata
Title
Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature
Authors
Fatma El-Husseiny Moustafa
Eman Nagy
Salwa Mahmoud Elwasif
Mohamed Sobh
Publication date
01-12-2023

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