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01-03-2021 | Kidney Injury | Original Article

Comparing predictive values of carbohydrate antigen 19-9, neutrophil gelatinase–associated lipocalin, and kidney injury molecule-1 in 161 patients with ureteropelvic junction obstruction

Authors: Kiarad Fendereski, Amirreza Nabighadim, Maryam Seyedtabib, Seyedeh Sima Daryabari, Mohammad Taghi Haghi-Ashtiani, Abdol-Mohammad Kajbafzadeh

Published in: Pediatric Nephrology | Issue 3/2021

Abstract

Background

To evaluate and compare the efficacy of urinary carbohydrate antigen 19-9 (CA19-9), neutrophil gelatinase–associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1) biomarkers as predictive factors to determine the surgery requirement in patients with ureteropelvic junction obstruction.

Methods

We obtained urine samples from 161 patients at diagnosis and evaluated their levels of the three biomarkers. The patients were under observation for 2 years; subsequently, they were divided into two groups based on their requirement of pyeloplasty. We determined the correlation between the urinary concentration of the biomarkers and surgical interventions, as well as the kidney function deterioration and sonography outcomes.

Results

The non-surgery group included 60 male and 22 female patients with mean age of 21 months. The surgery group comprised 58 boys and 21 girls with mean age of 26.9 months with no significant difference of age and gender between the two groups. The outcomes were indicative of higher efficacy of CA19-9 level with a sensitivity and specificity of 84.2% and 73.2% at the cutoff point of 59.09 U/ml. Also, a significant negative correlation was detected between the kidney function and the concentrations of CA19-9 and NGAL.

Conclusions

Our evaluations demonstrate the higher efficacy of CA19-9 to predict the requirement of surgical intervention in comparison with the other biomarkers, as well as a significant correlation between kidney function deterioration and urinary CA19-9 and NGAL. The outcomes of this investigation could pave the way for more extensive clinical application of these urinary biomarkers, besides future research determining the association between markers and kidney fibrosis.

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Title: Comparing predictive values of carbohydrate antigen 19-9, neutrophil gelatinase–associated lipocalin, and kidney injury molecule-1 in 161 patients with ureteropelvic junction obstruction
Authors: Kiarad Fendereski
Amirreza Nabighadim
Maryam Seyedtabib
Seyedeh Sima Daryabari
Mohammad Taghi Haghi-Ashtiani
Abdol-Mohammad Kajbafzadeh
Publication date: 01-03-2021
Publisher: Springer Berlin Heidelberg
Keywords: Kidney Injury
Pyeloplasty
Ureteropelvic Junction Obstruction
Pyeloplasty
Biomarkers
Published in: Pediatric Nephrology / Issue 3/2021
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-020-04750-w

At a glance: The STEP trials

Springer Medicine

Comparing predictive values of carbohydrate antigen 19-9, neutrophil gelatinase–associated lipocalin, and kidney injury molecule-1 in 161 patients with ureteropelvic junction obstruction

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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