Issue Special Issue 3/2012
7th European Workshop on Immune-Mediated Inflammatory Diseases
Content (84 Articles)
Abstract not submitted for publication
Abstract not submitted for publication
Lighting a candle in the dark: advances in the genetics and (gene) therapy of retinal dystrophies
Anneke I den Hollander
Abstract not submitted for publication
Patient stratification and genomics: flares, fizzlers and foxes
Kenneth GC Smith
Finding new immune regulatory genes by ENU mutagenesis
Anselm Enders, Hannes Bergmann, Mehmet Yabas, T Dan Andrews, Belinda Whittle, Mathew Field, Bhavani Balakishnan, Yovina Sontani, Lisa Miosge, Geoff Sjollema, Stuart Read, Ed Bertram, Chris C Goodnow
Type 1 regulatory T (Tr1) cells: from the bench to the bedside
Silvia Gregori, Rosa Bacchetta, Manuela Battaglia, Maria Grazia Roncarolo
What does it take to be healthy? Investigating immune-deficiency in non-immunodeficient scenarios
Elisa Binda, Reiner Schulz, Ania Showera, Andrew Cope, Michael Malim, John Cason, Mark Peakman, Adrian Hayday
Follicular lymphomagenesis: early steps and associated risk factors
Sandrine Roulland
Abstract not submitted for publication
Type 1 diabetes - an auto-inflammatory disease: a new concept, new therapeutical strategies
Catarina Limbert
Abstract not submitted for publication
IL-12 superfamily members guiding the function of Rorγt-dependent innate lymphocytes
Burkhard Becher
Role of human innate lymphoid cells in IMID
Hergen Spits, Jochem Bernink, Charlotte Peters, Jenny Mjosberg
NF-kappaB inducing kinase (NIK) is a key regulator of inflammation-induced angiogenesis
Ae-Ri Noort, Katinka PM van Zoest, Pieter Koolwijk, Paul-Peter Tak, Sander W Tas
Graft versus host disease in humanized mice is differentially controlled by CD28 and CD80/86 antagonists
Nicolas Poirier, Nahzli Dilek, Caroline Mary, Bernard Vanhove
Analysis of dendritic cells in human lymphoid organs
Gordon F Heidkamp, Nathalie Eissing, Lukas Heger, Robert Cesnjevar, Arndt Hartmann, Johannes Zenk, Evelyn Ulrich, Andreas Mackensen, Gerold Schuler, Burkhard Schauf, Falk Nimmerjahn, Diana Dudziak
No lack of regulatory B cells in patients with Multiple Sclerosis
Laure Michel, Mélanie Chesneau, Philippe Manceau, Alexandra Garcia, Marion Salou, Annie Elong Ngono, Annaïck Pallier, Marylène Jacq-Foucher, Fabienne Lefrère, Sandrine Wiertlewski, Jean-Paul Soulillou, Nicolas Degauque, David-Axel Laplaud, Sophie Brouard
The role of Bob1 in rheumatoid arthritis: potential implications for autoimmunity
Nataliya Yeremenko, Tineke Cantaert, Melissa N van Tok, Ioana Gofita, Juan D Canete, Paul-Peter Tak, Hergen Spits, Dominique L Baeten
Role of Ras isoforms in γδ T-cell development
Ana V Marín-Marín, Eva Jiménez Pérez, Eugenio Santos, Edgar Fernández-Malavé
Factor Xa and thrombin induce epithelial-mesenchymal transition by retinal pigment epithelial cells via PDGF-Rβ signaling
Jeroen Bastiaans, Jan C van Meurs, Conny van Holten-Neelen, Nicole MA Nagtzaam, P Martin van Hagen, Herbert Hooijkaas, Willem A Dik
FcRn mediated IgG transport by retinal pigment epithelium cells
Nicoline M Korthagen, Kiki van Bilsen, Willem A Dik, Jeroen Bastiaans, Marion Kolijn, Robert W Kuijpers, Martin van Hagen
Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45RO+CD25+CD127low regulatory T cells
Gina J Walter, Hayley G Evans, Bina Menon, Bruce W Kirkham, Andrew P Cope, Frederic Geissmann, Leonie S Taams
Human circulating basophils lack the features of professional antigen presenting cells
Meenu Sharma, Pushpa Hegde, Vishukumar Aimanianda, Jean-Paul Latgé, Srini V Kaveri, Jagadeesh Bayry
Decreased AIRE and promiscuous gene expression in thymus from Down syndrome individuals may explain predisposition to autoimmunity
Roger Colobran, Maria del Pilar Armengol, Eduard Porta, Paula A Correa, Ricardo Pujol-Borrell
Differential regulation of motility and immune synapses by CD28/ CTLA-4 costimulation in effector and regulatory T cells
Nahzli Dilek, Nicolas Poirier, Philippe Hulin, Gilles Blancho, Bernard Vanhove
Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps–SHP-2 pathway
Sheng Xu, Jin Hou, Xingguang Liu, Chaofeng Han, Peng Zhang, Xuetao Cao
Distal renal tubular acidosis in primary Sjögren syndrome
Tim Both, Ewout J Hoorn, Zana Brkic, Marjan A Versnel, Jan AM van Laar, P Martin van Hagen, Robert Zietse, Paul LA van Daele
Dynamics of CXC group chemokine platelet factor 4 (PF4) plasma levels in non-small cell lung cancer (NSCLC)
Artjoms Spaks, Inta Jaunalksne, Simona Donina, Ainis Pirtnieks, Jelena Grusina-Ujumaza, Irina Spaka, Aurika Babjoniseva, Dainis Krievins
Basophil Activation Test in the prediction of anaphylactic reactions against Hymenoptera venom in patients suffering from Systemic Mastocytosis
Mark JA Rietveld, Marco WJ Schreurs, Jan AM van Laar, P Martin van Hagen, Paul LA van Daele
A case report of a lichenoid eruption in a young lady with Crohn’s disease
Farida Benhadou, Véronique Del Marmol
Dietary management of inflammatory diseases
Umar Bacha, Muhammad A Ali, Abdul Basit, Uzma Litaf
Peripheral blood leukocytes express differential chemokine receptor profiles in irritable bowel syndrome, Crohn’s disease and ulcerative colitis
Ludvig Linton, Emma Lindh, Hans Glise, Michael Eberhardson, Ola Winqvist
IL-17 as an important effector cytokine in a mouse model for S.typhimurium sepsis
Andrea Schroll, Manfred Nairz, Igor Theurl, Günther Weiss
Molecular factors modulating the anti-inflammatory activity of IVIg in ITP
Inessa Schwab, Falk Nimmerjahn
Mesenchymal stem cells repress Th17 molecular program through the PD-1 pathway
Patricia Luz-Crawford, Daniele Noël, Fernando Figueroa, Flavio Carrión, Christian Jorgensen, Farida Djouad
Antagonist properties of monoclonal antibodies to human CD28: role of valency and heavy-chain constant domain
Caroline Mary, Flora Coulon, Nicolas Poirier, Nahzli Dilek, Bernard Martinet, Gilles Blancho, Bernard Vanhove
Lymphocytes subset composition and modulation of sphingosie-1-phosphate mediated migration in multiple sclerosis patients treated with fingolimod or interferon-β
Heiko Sic, Michael Stock, Sebastian Rauer, Hermann Eibel
SOCS2 expression in bone marrow derived dendritic cells is a positive regulator of T cell activation
Jin Hu, Berit Carow, Ann-Charlotte Wikström, Martin Rottenberg, Gunnar Norstedt, Ola Winqvist
Altered innate functions of myeloid dendritic cells in ANCA-associated vasculitis
Cécile Braudeau, Antoine Néel, Marie Rimbert, Mohamed Hamidou, Régis Josien
Vascular endothelial growth factor genetic polymorphisms and susceptibility to age-related macular degeneration in Tunisian population
Imen Habibi, Imen Sfar, Fedra Kort, Ahmed Chebil, Rim Bouraoui, Rim Limaiem, Salwa Jendoubi-Ayed, Mouna Makhlouf, Taïeb Ben Abdallah, Khaled Ayed, Leila El Matri, Yousr Gorgi
Macrophage-fibroblast interplay: a target for neuropeptide-based treatment of fibrotic disease?
Sita Virakul, Willem A Dik, Leo J Hofland, P Martin van Hagen, Virgil ASH Dalm
PIM2 induced MMP-9 expression in macrophages requires PI3K and Notch1 signaling
Nisha Kapoor, Kushagra Bansal, Germain Puzo, Martine Gilleron, KN Balaji
Influence of activating Fcgamma receptors on osteoclast differentiation and bone metabolism
Michaela Seeling, Jan Peter Tuckermann, Jean Pierre David, Georg Schett, Falk Nimmerjahn
Deficiency of regulatory B cells in a house dust mite model of asthma
Faouzi Braza, Julie Chesné, G Mahay, MA Cheminant, D Lair, K Botturi-Cavaillès, Antoine Magnan, Sophie Brouard
Characterization of murine experimental autoimmune encephalomyelitis induced by active immunization with a CD8 epitope of myelin oligodendrocyte glycoprotein
Flora Guillot, Sophie Brouard, David A Laplaud, Arnaud B Nicot
Tolerogenic dendritic cells in experimental autoimmune encephalomyelitis, specific tolerance induction?
Carla Sellés-Moreno, Cristina Ramo-Tello, Laia Grau-López, Ricardo Pujol-Borrel, Eva M Martínez-Cáceres
The reason to stop infliximab is clearly related to the existence of new alternatives: a correspondence analysis of biologics, reasons to stop, and time periods
Julia Uceda, Loreto Carmona, Alejandro Muñoz, Jose L Marenco
Changes in nailfold videocapillaroscopy in patients with granulomatosis with polyangiitis (Wegener’s): an observational study
Julia Uceda, Rosalía Martinez, María L Velloso, José L Marenco
Expression of 9G4 idiotope on autoantibodies to citrullinated peptides in patients with early inflammatory arthritis and established rheumatoid arthritis
Rita A Moura, Inmaculada de la Torre, Maria J Leandro, Jonathan CW Edwards, João E Fonseca, Geraldine Cambridge
TRAF1/C5 locus is associated with response to anti-TNF in rheumatoid arthritis
Helena Canhão, Ana Rodrigues, Maria Jose Santos, Diana Carmona-Fernandes, José Costa, Helena Santos, Jaime Branco, Robert Plenge, Daniel Solomon, Jacome Armas, José António Silva, João Eurico Fonseca, Elizabeth Karlson
Impaired NK and NKT cells immunobiology in rheumatoid arthritis
Ashish Aggarwal, Aman Sharma, Archana Bhatnagar
Extrathymic Autoimmune Regulator (AIRE) expression in rheumatoid arthritis
Ae-Ri Noort, Katinka PM van Zoest, M Christina Lebre, Paul-Peter Tak, Sander W Tas
Relative overexpression of membrane-bound versus soluble TNF in spondyloarthritis
Carmen A Ambarus, Leonie M van Duivenvoorde, Huriatul Masdar, Melissa N van Tok, Paul-Peter Tak, Nataliya G Yeremenko, Dominique L Baeten
BAFF polymorphisms and serum levels of BAFF in Tunisian systemic lupus erythematosus patients
Nacira Laamiri, Imen Sfar, Tarak Dhaouadi, Lamia Ben Hassine, Salwa Jendoubi-Ayed, Awatef Chiha, Thouraya Ben Romdhane, Mouna Makhlouf, Taïeb Ben Abdallah, Narjess Khalfallah, Khaled Ayed, Yousr Gorgi
Decreased expression of TSLP in labial salivary glands of patients with primary Sjögren’s syndrome is associated with local- and systemic disease parameters
Maarten R Hillen, Angela Bikker, Aike A Kruize, Marion Wenting-van Wijk, Floris PJG Lafeber, C Erik Hack, Timothy RDJ Radstake, Joel AG van Roon
Telomere biology is differently affected within clinical subsets of systemic sclerosis and points towards different downstream defects
Jasper CA Broen, Liane McGlynn, Meng May Chee, Lenny Geurts-van Bon, Robert L Lafyatis, Timothy RDJ Radstake, Paul G Shiels
Expression of PPARα, β, and γ in the Hartley guinea pig model of primary osteoarthritis
Fatima Ezzahra El Mansouri, Salwa Sarah Nebbaki, Nadia Zayed, Mohamed Benderdour, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Hassan Fahmi
Egr-1 mediates the suppressive effect of IL-1 on PPARγ expression in human OA chondrocytes
Salwa Sarah Nebbaki, Fatima Ezzahra El Mansouri, Nadia Zayed, Mohamed Benderdour, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Hassan Fahmi
Immunomodulatory actions of methotrexate on T cells in juvenile idiopathic arthritis
Maja Bulatović Ćalasan, Sebastiaan Vastert, Frederik Verweij, Nico Wulffraat, Femke van Wijk, Berent Prakken
Analysis of autoantibodies against Ro52/Ro60 in patients with suspected diagnosis of autoimmune systemic disease
Iñaki Salvador, Estibaliz Ruiz-Ortiz, Alejandro Olivé, Domingo Escudero, Isabel Bielsa, Eva Martínez-Cáceres
The effects of anti–TNF agents on the expansion of T helper-type 17 cells driven by lipopolysaccharide-stimulated monocytes
Gianluca Fossati, Louise Healy, Andrew Nesbitt
Particularities of anaemia in framework of systemic lupus erythematosus
Elena Samohvalov, Lucia Mazur-Nicorici, Ninel Revenco, Minodora Mazur
Prediction of treatment response by anticitrullinated protein antibodies (ACPA) levels among patients with rheumatoid arthritis
Raquel Hernández, Paz González, Alejandro Muñoz, Jose Luis Marenco
IL-1 receptor antagonist restores IL-18 NK cell axis in systemic JIA
Sebastiaan J Vastert, Wilco De Jager, Bo Jan Noordman, Berent J Prakken, Nico M Wulffraat
Juvenile idiopathic arthritis treated with biological therapies
Maria Luisa Velloso Feijoo, Rosalia Martinez Perez, Julia Uceda Montañes, Jose Luis Marenco de la Fuente
Seronegative and seropositive rheumatoid arthritis treated with rituximab
Maria Luisa Velloso Feijoo, Rosalia Martínez Pérez, Lucia González Mayordomo, Jose Luis Marenco de la Fuente
NAMPT/Visfatin expression by inflammatory monocytes mediates arthritis pathogenesis by promoting IL-17–producing T cells
Jessy Présumey, Gabriel Courties, Pascale Louis-Plence, Virginie Escriou, Daniel Scherman, Yves-Marie Pers, Hans Yssel, Jérôme Pène, Diego Kyburz, Steffen Gay, Christian Jorgensen, Florence Apparailly
TNF-inhibitor drugs regulate human pathogenic Th17 cells through induction of IL-10
Hayley G Evans, Nicola J Gullick, Gina J Walter, Urmas Roostalu, Klaus S Frederiksen, Jens G Gerwien, Andrew P Cope, Frederic Geissmann, Bruce W Kirkham, Leonie S Taams
Wegener granulomatosis: type of presentation and initial treatment in a series of 23 cases
Rosalia Martínez-Pérez, Mario Leon, Julia Uceda, S Rodriguez Montero, A Muñoz, ML Velloso, JL Marenco
Clinical and economic efficiency to reduce dose etanercept and adalimumab in patients with rheumatoid arthritis
Rosalía Martínez-Pérez, Sergio Rodríguez-Montero, Alejandro Muñoz, Julia Uceda, Mario León, Francisco Gallo, Maria Luisa Velloso, José Luis Marenco
Response measures influence comparative effectiveness of biological drugs in rheumatoid arthritis
Helena Canhao, Vasco Romao, Fernando Martins, Joao Eurico Fonseca
HLA and non-HLA genes in Behçet’s disease: a multicentric study in the Spanish population
Marco Antonio Montes-Cano, Marta Conde-Jaldon, Jose Raul Garcia-Lozano, Lourdes Ortiz-Fernandez, Maria Francisca Gonzalez-Escribano
MicroRNAs underlie plasmacytoid dentritic cell dysfunction in systemic sclerosis
Jasper C Broen, Lenny van Bon, Nick P Rossen, Marzia Rossato, Timothy RDJ Radstake
Inducible Treg cell populations as cell based-therapy for rheumatoid arthritis
Delphine Martire, Julie Quentin, Anne-Laure Mausset-Bonnefont, Hélène Asnagli, Nathalie Belmonte, Arnaud Foussat, Christian Jorgensen, Pascale Louis-Plence
LPS-induced gene expression of inflammation-related genes in neutrophils from familial Mediterranean fever patients
Gayane Manukyan, Eva Kriegova, Anush Martirosyan, Regina Fillerova, Maretta Tatyan, Martin Petrek
Isolated anti-Ku antibody in scleroderma-myositis overlap syndrome: the histo-pathological patern
Bernard Azanmene, Valerie Badot, Severine Verlinden, Maria Josee Fernandez-Lopez, Hazim Kadhim, Francis Corazza, Wolfram Fink, Anne Peretz, Jacques Bentin
Autoimmunity and cystatin SA 1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome
Emma Lindh, Johan Brännström, Petra Jones, Fredrik Wermeling, Signe Hässler, Corrado Betterle, Ben Zion Garty, Mats Stridsberg, Björn Herrmann, Mikael CI Karlsson, Ola Winqvist
A phenotypic, transcriptional and TCR Vβ repertoire signature of CD8+ T cells define a population at-risk of long-term kidney graft dysfunction
Nicolas Degauque, Françoise Boeffard, Annaick Pallier, Richard Danger, Magali Giral, Jacques Dantal, Yohann Foucher, Cécile Guillot-Gueguen, Jean-Paul Soulillou, Sophie Brouard
Control of transplant tolerance and intragraft regulatory T cell localization by CCL5
Nahzli Dilek, Nicolas Poirier, Claire Usal, Bernard Martinet, Gilles Blancho, Bernard Vanhove
Evaluation of FR104, a Treg sparing antagonist anti-CD28 monovalent Fab’ antibody in kidney transplantation in non-human primates
Nicolas Poirier, Nahzli Dilek, Caroline Mary, Jeremy Hervouet, David Minault, Julien Branchereau, Xavier Tillou, Stephanie Le Bas-Bernardet, Bernard Vanhove, Gilles Blancho
Inhibition of cystathionine-γ-lyase controls interleukin-12 production by dendritic cells, delayed-type hypersensitivity and transplant rejection
Romain Vuillefroy de Silly, Flora Coulon, Nicolas Poirier, Vojislav Jovanovic, Sophie Brouard, Véronique Ferchaud-Roucher, Gilles Blancho, Bernard Vanhove