Drugs - Real World Outcomes OnlineFirst articles

Open Access 21-05-2024 | Author Correction

Correction: Efficacy of Three Teriparatide Preparations and Romosozumab, Osteogenesis Promoters, in the Treatment of Fresh Vertebral Fractures: A Retrospective Observational Study

Author:: Kouken Hayashi

Open Access 10-05-2024 | Esketamine | Original Research Article

Treatment Patterns, Acute Healthcare Resource Use, and Costs of Patients with Treatment-Resistant Depression Completing Induction Phase of Esketamine in the United States

Treatment-resistant depression (TRD) represents a form of major depressive disorder (MDD) that is defined as inadequate response to two or more antidepressant courses of adequate dose and duration [ 1 ]. TRD affects 1.1% of the adult population in …

Authors:: Lisa Harding, Kruti Joshi, Maryia Zhdanava, Aditi Shah, Arthur Voegel, Cindy Chen, Dominic Pilon

Open Access 10-05-2024 | Fibrates | Original Research Article

Safety of Combined Statin and Fibrate Therapy: Risks of Liver Injury and Acute Kidney Injury in a Cohort Study from the Shizuoka Kokuho Database

Statins and fibrates are effective means of reducing circulating lipid levels, and play vital roles in the primary and secondary prevention of cardiovascular diseases [ 1 ]. Statins, which inhibit the 3-hydroxy-3-methylglutaryl-coenzyme A reductase …

Authors:: Yohei Sobukawa, Taichi Hatta, Daito Funaki, Eiji Nakatani

Open Access 10-05-2024 | Ritonavir | Original Research Article

Economic Evaluation of Nirmatrelvir/Ritonavir Among Adults Against Hospitalization During the Omicron Dominated Period in Malaysia: A Real-World Evidence Perspective

Nirmatrelvir/ritonavir (Paxlovid TM ) was the first oral antiviral agent to receive an emergency use authorisation (EUA) from the US Food and Drug Administration (FDA) for the treatment of mild to moderate COVID-19 patients [ 1 ]. This EUA was …

Authors:: Ee Vien Low, Hoon Shien Teh, Nicholas Yee Liang Hing, Suresh Kumar Chidambaram, Mohan Dass Pathmanathan, Wee Ric Kim, Wei Jia Lee, Zhi Wei Teh, Maheshwara Rao Appannan, Shahanizan Mohd Zin, Faizah Muhamad Zin, Samha Bashirah Mohamed Amin, Mastura Ismail, Azah Abdul Samad, Kalaiarasu M. Peariasamy

Open Access 10-04-2024 | Rheumatoid Arthritis | Original Research Article

Treatment Patterns of Biologic Disease-Modifying Antirheumatic Drugs and Janus Kinase Inhibitors in Patients with Rheumatoid Arthritis in Japan: A Claims-Based Cohort Study

Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune joint disease that can cause cartilage and bone damage as well as disability, which may negatively impact patients’ ability to perform daily activities and reduce health-related …

Authors:: Masahiko Miyashiro, Teita Asano, Yutaka Ishii, Celine Miyazaki, Hirohito Shimizu, Junya Masuda

Open Access 06-04-2024 | Pseudarthrosis | Correction

Correction to: Efficacy of Three Teriparatide Preparations and Romosozumab, Osteogenesis Promoters, in the Treatment of Fresh Vertebral Fractures: A Retrospective Observational Study

Author:: Kouken Hayashi

Open Access 06-04-2024 | Diarrhea | Original Research Article

Effectiveness of Saccharomyces boulardii CNCM I-745 in Adult Indian Patients with Diarrhoea: A Real-world, Multicentre, Retrospective, Comparative Study

Diarrhoea is defined by the World Health Organization (WHO) as the passage of three or more loose or watery stools per day [ 1 ]. The etiological factors related to diarrhoea include infections from bacterial, viral or protozoal organisms, and …

Authors:: Bhaskar Bikash Pal, Rupali Vinodchandra Bandagi, Kranthi Kiran Pebbili, Rahul Rathod, Bhavesh Kotak, Gauri Dhanaki, Snehal Shah

Open Access 02-04-2024 | Daptomycin | Original Research Article

Ceftaroline Fosamil for the Treatment of Methicillin-Resistant Staphylococcus Aureus Bacteremia: A Real-World Comparative Clinical Outcomes Study

Methicillin-resistant Staphylococcus aureus (MRSA) continues to represent a significant public health challenge, estimated to result in more than 80,000 invasive infections and 11,000 deaths every year in the USA alone [ 1 ]. MRSA bacteremia is …

Authors:: Jennifer Hammond, Michael Benigno, Nataly Bleibdrey, Wajeeha Ansari, Jennifer L. Nguyen

Open Access 01-04-2024 | Clozapine | Short Communication

Relationship Between Clozapine and Non-Hematological Malignant Tumors: A Pharmacovigilance Analysis Using the FDA Adverse Event Reporting System Database

Schizophrenia is a psychiatric disorder that is characterized by positive symptoms, including hallucinations and delusions, negative symptoms, such as reduced motivation and decreased emotional expression, and cognitive impairment. Schizophrenia …

Authors:: Yuichi Uwai, Tomohiro Nabekura

Open Access 19-03-2024 | Iron Deficiency Anemia | Original Research Article

Effect of Ferric Carboxymaltose Versus Low-Dose Intravenous Iron Therapy and Iron Sucrose on the Total Cost of Care in Patients with Iron Deficiency Anemia: A US Claims Database Analysis

Iron deficiency is one of the most common causes of anemia. Iron is needed for many cellular functions, including erythropoiesis, and the resulting reduction in hemoglobin (Hgb) concentration due to the deficiency of iron may lead to symptoms such …

Authors:: Winghan Jacqueline Kwong, Kevin Wang, Peng Wang, Ralph Boccia

Open Access 18-02-2024 | Disease Modifying Anti-Rheumatic Drug | Original Research Article

Disease-Modifying Medications in Patients with Rheumatoid Arthritis in the USA: Trends from 2016 to 2021

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder with primary clinical manifestations of symmetrical inflammatory polyarthritis, starting often with the small joints of the hands and feet, and spreading to other larger …

Authors:: Samuel K. Peasah, Elizabeth C. S. Swart, Yan Huang, Sandra L. Kane-Gill, Amy L. Seybert, Urvashi Patel, Chronis Manolis, Chester B. Good

Open Access 13-02-2024 | Allergic Rhinitis | Original Research Article

An Observational Study to Determine the Real-Life Effectiveness of MP-AzeFlu® in Austrian Patients with Persistent Allergic Rhinitis

Allergic rhinitis (AR) is a highly prevalent allergic respiratory disease affecting approximately 24% of the European population [ 1 ], and many patients with AR have moderate-to-severe persistent disease [ 2 ]. Allergic rhinitis symptoms include …

Authors:: Katharina Marth, Andreas Renner, Georg Langmayr, Wolfgang Pohl, Duc Tung Nguyen, Hans Christian Kuhl

Open Access 06-02-2024 | Original Research Article

Causality Assessment Between Drugs and Fatal Cerebral Haemorrhage Using Electronic Medical Records: Comparative Evaluation of Disease-Specific and Conventional Methods

In pharmacovigilance, adverse drug reaction reports are an essential source of information. Causality assessment of individual cases forms the basis of safety measures for medicinal products [ 1 , 2 ]. Since clinical trials involve only a limited …

Authors:: Miki Ohta, Satoru Miyawaki, Shinichiroh Yokota, Makoto Yoshimoto, Tatsuya Maruyama, Daisuke Koide, Takashi Moritoyo, Nobuhito Saito

Open Access 24-01-2024 | Cabozantinib | Original Research Article

Cabozantinib and Axitinib After Vascular Endothelial Growth Factor Therapy in Patients with Advanced Renal Cell Carcinoma: A Retrospective Cohort Study from England

In 2020, the age-standardized incidence of kidney cancer was 4.6 per 100,000 people globally and 10.3 per 100,000 people in the UK [ 1 , 2 ]. Of the estimated 13,300 people diagnosed with kidney cancer per year in the UK [ 3 ], most have renal cell …

Authors:: Janet Brown, Brooke Harrow, Anne Marciniak, Christine McCarthy, Aude Houchard, Lori Cirneanu, Andrew Protheroe

Open Access 19-01-2024 | Paracetamol | Original Research Article

Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy

Herbal medicines are used worldwide to treat various conditions during pregnancy [ 1 – 3 ]. Their usage is up to 60% in developed countries is primarily because of the perception that herbs are natural and do not pose adverse effects, unlike …

Authors:: Aoi Noda, Taku Obara, Fumiko Matsuzaki, Satoko Suzuki, Ryutaro Arita, Minoru Ohsawa, Ryo Obara, Kei Morishita, Fumihiko Ueno, Genki Shinoda, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Hiroshi Kawame, Shigeo Kure, Shinichi Kuriyama

Open Access 18-01-2024 | Anti-Influenza Drug | Short Communication

Trends in Anti-Influenza Drug Prescription and Adverse Drug Reaction Reporting After the Lifting of Oseltamivir Prescribing Restrictions in Pediatric Outpatients: An Ecological Study Using the MDV Analyzer® And the Japanese Adverse Drug Event Report Database

Oseltamivir phosphate (oseltamivir) is one of the drugs with a high frequency of adverse drug reactions (ADRs) in pediatric patients [ 1 ]. In November 2005, abnormal behavior after oseltamivir use was widely reported in the media, raising public …

Authors:: Misaki Tokunaga, Daisuke Kikuchi, Aoi Noda, Sachiko Oikawa, Makoto Shiozawa, Hiroaki Hino, Ryosuke Miura, Kensuke Usui, Taku Obara, Kouji Okada

Keynote webinar | Spotlight on medication adherence

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