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Esketamine 

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  1. Open Access 10-05-2024 | Esketamine | Online First

    Treatment Patterns, Acute Healthcare Resource Use, and Costs of Patients with Treatment-Resistant Depression Completing Induction Phase of Esketamine in the United States

    Treatment-resistant depression (TRD) represents a form of major depressive disorder (MDD) that is defined as inadequate response to two or more antidepressant courses of adequate dose and duration [ 1 ]. TRD affects 1.1% of the adult population in …

  2. 01-03-2024 | Esketamine | News

    Esketamine/methadone/oxycodone

    Various toxicities and lack of efficacy
  3. Open Access 01-12-2024 | Esketamine | OriginalPaper

    Effects of a single subanesthetic dose of esketamine on postoperative subthreshold depressive symptoms in patients undergoing unilateral modified radical mastectomy: a randomised, controlled, double-blind trial

    Breast cancer is the most common malignant tumor in females worldwide. Based on the 2020 global tumor epidemiological statistics, breast cancer had an annual diagnosis of approximately 2.3 million cases worldwide. This number exceeds the incidence …

  4. Open Access 01-12-2024 | Sufentanil | OriginalPaper

    Effect of pretreatment with a small dose of esketamine on sufentanil-induced cough during anesthesia induction: a randomized controlled trial

    The frequent use of sufentanil as an induction agent is due to its strong analgesic properties, short duration of action, and cardiovascular stability. However, The cough caused by sufentanil can occur during anesthesia induction. The prevalence …

  5. Open Access 01-12-2024 | Esketamine | OriginalPaper

    Efficacy and safety of esketamine combined with propofol for curative endoscopic resection in colorectum: a prospective, randomized controlled trial

    The incidence of colon polyps and early-stage colon cancer remains high in China. Curative endoscopic resection is now the primary method for mini-trauma, with a short operation duration, shorter length of stay, and rapid recovery. The current …

  6. Open Access 01-12-2024 | Esketamine | OriginalPaper

    A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children

    The need for pain management and sedation are common in the Emergency Departments (EDs) treating pediatric trauma patients. Every fifth pediatric ED visit is due to trauma [ 1 ] and a peak incidence is seen in young children [ 1 , 2 ]. Their …

  7. 04-04-2024 | Esketamine | Online First

    Observation on the Analgesic Effect of Different Doses of a Combination of Esketamine and Dexmedetomidine Administered for Percutaneous Endoscopic Transforaminal Discectomy: A Randomized, Double-Blind Controlled Trial

    With the advancement of minimally invasive techniques in spinal surgery, percutaneous endoscopic transforaminal discectomy (PETD) has become one of the commonly used surgical methods for treating lumbar disc herniation, due to its advantages such …

  8. Open Access 01-12-2024 | Esketamine | OriginalPaper

    Effect of esketamine on postoperative analgesia and postoperative delirium in elderly patients undergoing gastrointestinal surgery

    With advances in medical technology, an increasing number of elderly patients are opting for surgical treatments to address ailments. As a result, there is growing concern among patients and healthcare professionals about anesthesia-related …

  9. Open Access 01-12-2024 | Esketamine | OriginalPaper

    The effect of esketamine combined with propofol-induced general anesthesia on cerebral blood flow velocity: a randomized clinical trial

    Ketamine is an intravenous anesthetic agent that exhibits favorable sedative and analgesic properties, which has a stimulating effect on the sympathetic nerves and circulation, and ketamine is the only drug in intravenous anesthesia that can …

  10. Open Access 01-12-2024 | Esketamine | OriginalPaper

    Safety and efficacy of low-dose esketamine in laparoscopic cholecystectomy: a prospective, double-blind randomized controlled trial

    Laparoscopic cholecystectomy, a common technique for treating gallbladder disease, is favored due to its relatively low complication rate, expedited postoperative recovery, minimized iatrogenic trauma, and decreased damage to the bile ducts [ 1 ].

  11. Open Access 01-12-2024 | Esketamine | OriginalPaper

    Effectiveness of perioperative low-dose esketamine infusion for postoperative pain management in pediatric urological surgery: a prospective clinical trial

    Postoperative pain management in children is often insufficient, with a considerable percentage (25–63%) of patients experiencing moderate to severe pain on the day following urological surgery, which can persist for up to nine days [ 1 ]. Acute …

  12. Open Access 01-12-2024 | OriginalPaper

    Efficacy of esketamine for the treatment of postpartum depression and pain control following cesarean section: a randomized, double-blind, controlled clinical trial

    Postpartum depression (PPD) is a prevalent psychological condition seen in females during the perinatal phase, characterized by a frequency ranging from 10 to 20%. Notably, the prevalence of PPD tends to be greater in middle and low-income nations …

  13. Open Access 01-12-2024 | OriginalPaper

    Comparison of the analgesic effect of dezocine and esketamine in combination with sufentanil respectively after laparoscopic cholecystectomy: a prospective randomized controlled study

    Acute cholecystitis, which is caused by gallstones, is a common clinical disease. Despite diverse treatment methods, laparoscopic cholecystectomy (LC) remains the gold standard for the surgical treatment of calculous cholecystitis [ 1 ]. Compared …

  14. Open Access 01-12-2024 | Esketamine | OriginalPaper

    Esketamine pretreatment during cesarean section reduced the incidence of postpartum depression: a randomized controlled trail

    Postpartum depression (PPD) is a common mental disorder in postpartum women, affecting about 10%-15% unipara [ 1 ], accounting for about 20% of maternal deaths [ 2 ]. It is reported that the incidence of PPD in Chinese is about 22%-28% [ 3 , 4 ].

  15. Open Access 01-12-2024 | Remifentanil | OriginalPaper

    Effect of esketamine on the EC50 of remifentanil for blunting cardiovascular responses to endotracheal intubation in female patients under general anesthesia: a sequential allocation dose-finding study

    Endotracheal intubation produces strong airway stimulation, which is no less intense than the stress produced by surgical skin incision [ 1 ]. The dramatic fluctuations in hemodynamics caused by sympathetic nerve excitation and the release of …

  16. Open Access 01-12-2024 | OriginalPaper

    Effective dose of propofol combined with intravenous esketamine for smooth flexible laryngeal mask airway insertion in two distinct age groups of preschool children

    Laryngeal mask airway (LMA) is commonly used for airway management during pediatric anesthesia, and compared with tracheal intubation, it has the advantages of low risk of anesthesia complications, short anesthesia time, and relatively small …

  17. Open Access 01-12-2024 | Esketamine | OriginalPaper

    Esketamine use is associated with shortened postoperative hospital stay in patients after knee arthroscopic surgery: a propensity score–matched cohort study

    Knee arthroscopy is a novel and minimally invasive surgical technique that has gained significant attention in the field of orthopedic surgery [ 1 ]. It involves the use of an arthroscope to visualize and treat internal knee joint diseases [ 2 ].

  18. Open Access 01-12-2024 | Esketamine | OriginalPaper

    Effect of esketamine on postpartum depression after labor analgesia and potential mechanisms: a randomized, double-blinded controlled trial

    Maternal health has always been the focus. With the physical and psychological changes, the incidence of maternal postpartum depression(PPD) is about 3.5%~33% [ 1 ]. The causes of PPD are complex and related to maternal genetic, physiological …

  19. Open Access 01-03-2024 | Esketamine | OriginalPaper

    Low-dose esketamine improves acute postoperative pain in patients undergoing thoracoscopic surgery

    Video-assisted thoracic surgery (VATS) is the primary and minimally invasive therapy for thoracic tumors in clinical practice. However, VATS still induces moderate to severe postoperative pain in patients as a result of incision damage, tissue …

  20. Open Access 01-12-2024 | Esketamine | OriginalPaper

    Effects of adding low-dose esketamine to sufentanil and propofol sedation during cervical conization: a single-centre, randomized controlled trial

    Despite efforts by the World Health Organization to eliminate cervical cancer, it remains a leading cause of morbidity and mortality in developing countries. Cervical conization is a commonly used excisional surgery for the treatment of cervical …

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