The classification of tumors is essential in the diagnosis and clinical management of patients with malignant neoplasms. The World Health Organization (WHO) provides a globally applicable classification scheme of neoplasms and it was updated …
Authors:
Ayoma D. Attygalle, John K. C. Chan, Sarah E. Coupland, Ming-Qing Du, Judith A. Ferry, Daphne de Jong, Dita Gratzinger, Megan S. Lim, Alina Nicolae, German Ott, Andreas Rosenwald, Anna Schuh, Reiner Siebert, on behalf of the WHO 5th Edition Classification Project
Langerhans cell histiocytosis (LCH) of the stomach is rare. Moreover, it is usually found in pediatric patients with systemic diseases and may be associated with a poor prognosis. Solitary gastric LCH in adults is extremely rare and is often …
A 71-year-old female with relapsed IgA lambda myeloma developed progressive cytopenia. The peripheral blood film showed 5% blastoid cells. Flow cytometry analysis was indicative of plasma cells. The bone marrow smear was packed with plasmablasts.
ALK-positive ( +) large B cell lymphoma (ALK + LBCL) is a rare distinct subtype of diffuse large B cell lymphoma presenting with high stage and aggressive behavior. Although B cell markers such as CD20, CD19, and CD22 are generally negative …
Authors:
Jess Baker, Sara L. Zadeh, Nadine S. Aguilera
Open Access
02-04-2024 | Lymphoma | Original Article
MYC-rearranged B-cell lymphoma (BCL) in the pediatric/young adult (YA) age group differs substantially in disease composition from adult cohorts. However, data regarding the partner genes, concurrent rearrangements, and ultimate diagnoses in these …
Authors:
Marie-France Gagnon, Frido K. Bruehl, Daniel R. Sill, Reid G. Meyer, Patricia T. Greipp, Nicole L. Hoppman, Xinjie Xu, Linda B. Baughn, Jess F. Peterson, Ellen D. McPhail, Rhett P. Ketterling, Rebecca L. King
Gamma delta (γδ) T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is a rare, aggressive subtype of T-lymphoid leukemia that accounts for only 9–12% of all T-ALL cases. Herein, we report the case of an 8-year-old boy who presented with facial …
Authors:
Giby V. George, Maggie Kajstura, Andrew G. Evans, Chauncey R. Syposs
In chronic myeloid leukemia (CML), patients exhibit the t(9;22)(q34.1;q11.2) translocation, resulting in the formation of a Philadelphia chromosome (Ph). However, a subset of CML patients display variant complex translocations, characterized by …
Authors:
Xiaoyu Bi, Chao Li, Miao Shang, Bingbing Han, Hongyu Li, Lidan Sun, Yani Lin, Shaobin Yang
Hemophagocytic lymphohistiocytosis is a severe hyperinflammatory syndrome that can be potentially life-threatening without appropriate treatment. Although viral infection is the most common trigger of hemophagocytic lymphohistiocytosis, cases of …
Authors:
Hanqing Zhang, Peng Zhang, Zhifang Xiao, Yang Gao, Na Han, Xianjun He, Jinfeng Zhang, Yonghua Li
