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Irish Journal of Medical Science (1971 -) OnlineFirst articles

Open Access 17-05-2024 | Original Article

Functional impairment and quality of life in newly diagnosed adults attending a tertiary ADHD clinic in Ireland

Attention Deficit-Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterised by either significant symptoms of inattention or hyperactivity and impulsiveness or a combination of the two. The current diagnostic criteria for ADHD …

Authors:
Dimitrios Adamis, Sam West, Jasmin Singh, Liadan Hanley, Iulian Coada, Geraldine McCarthy, Natasha Langan, Blánaid Gavin, Fiona McNicholas

16-05-2024 | Type 2 Diabetes | Original Article

The effect of nutritional education on blood glycemic, lipidemic, and body mass index control among sample of type 2 diabetes

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by poor glycemic control due to inadequate insulin production and insulin resistance [ 1 ]. The onset of T2DM is preceded by a decline in insulin secretion, followed by a …

Authors:
Hussein Alwan Mejbel, Lujain Anwar Alkhazrajy, Yousif AbdulRaheem

Open Access 15-05-2024 | Non-Invasive Ventilation | Original Article

Long-term outcomes in patients with COPD treated with non-invasive ventilation for acute hypercapnic respiratory failure

Despite declining rates of smoking in Europe and North America, Chronic Obstructive Lung Disease (COPD) remains a major cause of long-term morbidity and mortality with frequent hospitalizations adding to the cost of care [ 1 , 2 ]. Patients …

Authors:
Shane O’Brien, Cara Gill, Niall Cograve, Mark Quinn, Ruairi J. Fahy

15-05-2024 | Latanoprost | Original Article

Comparing the tolerability of preservative-free tafluprost versus preserved latanoprost in the management of glaucoma and ocular hypertension — an observer blinded active-control trial

Glaucoma is one of the leading causes of irreversible blindness worldwide, and it has been estimated that, by 2040, the number of people with glaucoma will have increased to approximately 112 million [ 1 ]. As available medical agents for treating …

Authors:
David Brinkman, Terence McSwiney, Mark James

Open Access 15-05-2024 | Myocardial Infarction | Original Article

Time to ECG diagnosis delays inter-hospital transfer to revascularization in STEMI patients presenting to a regional emergency department: a five-year audit

ST-elevation myocardial infarction (STEMI) is a cardiac emergency caused by the occlusion of an epicardial coronary artery, typically as the result of atherosclerotic plaque rupture and thrombus formation [ 1 ]. The guideline-directed treatment for …

Authors:
Jonathan Shpigelman, Anastasia Proshkina, Marin Roman, Ken Maleady, Ivan Casserly, Gavin Blake, Patrick O’Boyle, Lavanya Saiva, Edward Keelan, James O’Neill, Michael Daly

15-05-2024 | Type 2 Diabetes | Original Article

The link between serum neuregulin-1 and atherogenic index in type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is a common metabolic disease marked by persistently high blood sugar levels and changes in the metabolism of proteins, lipids, and carbohydrates as a result of deficiencies in the secretion and/or action of insulin …

Authors:
Wafaa Sh. Al–Zuhairi, Leila Sadeghi, Ekhlas Abdallah Hassan

Open Access 14-05-2024 | Epigenetics | Review Article

Can social adversity alter the epigenome, trigger oral disease, and affect future generations?

The nature versus nurture debate has intrigued scientific circles for decades. Although extensive research has established a clear relationship between genetics and disease development, recent evidence has highlighted the insufficiency of …

Authors:
Sakr Khalid, Michaela Kearney, David E. McReynolds

Open Access 14-05-2024 | Original Article

The potential protective role of vitamin D and calcium supplements in reducing cardiovascular disease risk among elderly patients with osteopenia

Cardiovascular diseases (CVD) and low bone mineral density (BMD) are serious health problems that hit many countries and cause significant morbidity and mortality. Both CVD and low BMD often occur concurrently and are associated with shared risk …

Authors:
Ramada R. Khasawneh, Hana S. Al-Soudi, Ejlal Abu-El-Rub, Ayman Alzu’bi, Raed M. Al-Zoubi

14-05-2024 | Arthrography | Original Article

Comparison of 3T MR arthrography and 3T MRI in intra-articular hip pathology: a cost-analysis

In recent years, there has been a growing interest in the evaluation of femoroacetabular impingement (FAI) and labral hip pathology due to its significant association with hip pain and impaired joint function [ 1 ]. The gold standard for evaluation …

Authors:
David T. Ryan, Marion Hanley, Annette White, John P. Hynes, Niamh M. Long, Stephen J. Eustace, Eoin C. Kavanagh

Open Access 13-05-2024 | Triage | Original Article

Expectations of emergency patients regarding triage system knowledge upon arrival: an interpretive study

One of the most important aspects of healthcare knowledge is having a thorough understanding of the triage system which is used in emergency departments [ 1 , 2 ]. When a patient seeks emergency care, the triage system is the first place they visit …

Authors:
Mohammad Minwer Alnaeem, Salam Salam Banihani, Asma Islaih, Ahmad R. Al-Qudimat

12-05-2024 | Lichen Planus | Original Article

Choroidal thickness and retinal vascular changes in patients with lichen planus: an inflammatory disease beyond the skin

Lichen planus (LP) is an idiopathic, cell-mediated inflammatory disorder of the skin and mucous membrane. LP presented clinically with pruritic, purple patches and papules predominantly affecting the wrists, lower back, and ankles, with a …

Authors:
Hala M. El-Sadek, Sahar Saad Eldeen Mohamed Shaban, Ayman Abdelmaksoud, Basma El-sayed Mohammad Risha, Mahmoud A. Rageh

09-05-2024 | Antidepressant Drugs | Case based reviews

A case series of musical hallucinations in psychiatry of old age—in search of the sound of silence

Musical hallucinations (MH) are the subjective experience of hearing music when none is played. They are a rare, understudied area of psychiatry. MH are more common in women and older age and have several underlying aetiologies and predisposing …

Authors:
Ralph Twomey, Anna Young, Caoimhe Clarke

03-05-2024 | Oral Cancer | Original Article

Short-term, nonsurgical periodontal therapy boosts interleukin-12 levels and reduces oral cancer risk

Common inflammatory risk factors present in patients with periodontal illnesses, such as chronic periodontitis, are also present in those with other systemic and chronic inflammatory disorders. They are a major cause of oral illness worldwide.

Authors:
Hazza A. Alhobeira, Anamika Sharma, Ananya Sharma, Mahvish Khan, Mohtashim Lohani, Saif Khan, Eslam K. Fahmy, Safya E. Esmaeel, Anshoo Agarwal

03-05-2024 | Chronic Kidney Disease | Original Article

Predictors of mortality, mortality rates, and clinical characteristics of adult patients with extreme hyperferritinemia

Ferritin is an iron-binding protein and a commonly ordered blood test in routine clinical practice [ 1 ]. While its main biologic role is to bind intracellular iron and prevent free iron toxicity, routinely measured ferritin is iron-poor …

Authors:
Alper Tuna Güven, Naciye Hocanın, Arif Emre Ambarkütükoğlu

30-04-2024 | Human Immunodeficiency Virus | Letter to the Editor

Letter to editor: Prophylactic use of statins in HIV patients: Better be safe than sorry

Authors:
Muhammad Hamza Shafiq, Fatima Farooq, Misha Mansoor, Muhammad Hassan Ahmad

Open Access 27-04-2024 | Original Article

Maxillofacial fractures among non-indigenous ethnic groups in the Irish national maxillofacial unit: a review

Facial injuries comprise a large component of the day-to-day running of maxillofacial units. In addition to the increased workload they create, these injuries are also cause of significant physical and mental morbidity to affected patients.

Authors:
Liam Costello, Akinsola Ogunbowale, Kumara Ekanayake

Open Access 23-04-2024 | Psychotherapy | Brief Report

Psychiatry and psychotherapy: the science of sitting with uncertainty

Author:
Aoibheann McLoughlin

Open Access 19-04-2024 | Parkinson's Disease | Original Article

Impacts of gait freeze on quality of life in Parkinson’s disease, from the perspectives of patients and their carers

The World Health Organisation (WHO) has reported that disability and death due to Parkinson’s disease (PD) are increasing faster than for any other neurodegenerative condition [ 1 ]. PD is the second most prevalent neurodegenerative illness …

Authors:
Padraig Cronin, Lucy M. Collins, Aideen M. Sullivan

19-04-2024 | Cervical Cancer | Original Article

High keratin 15 expression reflects favorable prognosis in early cervical cancer patients

Cervical cancer is one of the most frequent gynecological malignancies, which poses a huge health burden for women around the world [ 1 – 3 ]. It is reported that there are 109,741 new cases and 59,060 deaths of cervical cancer in China in 2020 [ 4 …]. With the launch of the cervical cancer screening program, more and more patients are diagnosed at an early stage, for whom the main therapy strategy is surgical treatment [

Authors:
Li Zhou, Ying Bi, Xiaoling Wu, Hong He

Open Access 19-04-2024 | Breast Cancer | Original Article

The impact of the COVID-19 pandemic on symptomatic breast cancer presentations in an Irish breast cancer unit: a retrospective cohort study

The first case of the COVID-19 virus was confirmed in Ireland on 26th February 2020 [ 1 ], with the first ensuing population-level lockdown ordered on 27th March 2020. Breast cancer services were disrupted at the onset of the pandemic due to the …

Authors:
Áine Higgins, Seamus O’Reilly, Martin J. O’Sullivan