Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Rheumatology International
Published in: Rheumatology International 12/2013

01-12-2013 | Letter to the Editor

IRAK1, a potential therapeutic target for rheumatoid arthritis?

Authors: Qiang Xie, Shi-Cun Wang, Jun Li

Published in: Rheumatology International | Issue 12/2013

Login to get access

Excerpt

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with hypertrophy, hyperplasia and angiogenesis of synovial tissue, which contribute to inflammatory joint destruction [1]. Although the exact causes of RA remain unknown, immunological dysregulation by inflammatory cytokines has been shown to be involved in driving the inflammation and synovial cell proliferation that characterize joint destruction in RA patients. …
Literature
1.
Iguchi T, Ziff M (1986) Electron microscopic study of rheumatoid synovial vasculature. Intimate relationship between tall endothelium and lymphoid aggregation. J Clin Invest 77:355–361PubMedCrossRef
2.
Zhang H, Pu J, Wang X, Shen L, Zhao G, Zhuang C et al (2012) IRAK1 rs3027898 C/A polymorphism is associated with risk of rheumatoid arthritis. Rheumatol Int. doi:10.​1007/​s00296-012-2379-3
3.
Chatzikyriakidou A, Voulgari PV, Georgiou I, Drosos AA (2010) A polymorphism in the 3′-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility. Joint Bone Spine 77:411–413PubMedCrossRef
4.
Martin MU, Wesche H (2002) Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family. Biochim Biophys Acta 1592:265–280PubMedCrossRef
5.
Yokota K, Miyazaki T, Hemmatazad H, Gay RE, Kolling C, Fearon U et al (2011) The pattern-recognition receptor NOD1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. doi:10.​1002/​art.​34318
6.
Cho ML, Ju JH, Kim HR, Oh HJ, Kang CM, Jhun JY (2007) Toll-like receptor 2 ligand mediates the upregulation of angiogenic factor, vascular endothelial growth factor and interleukin-8/CXCL8 in human rheumatoid synovial fibroblasts. Immunol Lett 108:121–128PubMedCrossRef
7.
Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, Chan EK (2008) Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther 10:R101PubMedCrossRef
8.
Mosaad YM, Abdelsalam A, El-Bassiony SR (2011) Association of tumour necrosis factor-alpha -308 G/A promoter polymorphism with susceptibility and disease profile of rheumatoid arthritis. Int J Immunogenet 38:427–433PubMedCrossRef
9.
Chiang EY, Yu X, Grogan JL (2011) Immune complex-mediated cell activation from systemic lupus erythematosus and rheumatoid arthritis patients elaborate different requirements for IRAK1/4 kinase activity across human cell types. J Immunol 186:1279–1288PubMedCrossRef
Metadata
Title
IRAK1, a potential therapeutic target for rheumatoid arthritis?
Authors
Qiang Xie
Shi-Cun Wang
Jun Li
Publication date
01-12-2013
Publisher
Springer Berlin Heidelberg
Published in
Rheumatology International / Issue 12/2013
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-012-2579-x

Other articles of this Issue 12/2013

Rheumatology International 12/2013 Go to the issue

Short Communication

The effects of fenofibrate on inflammation and cardiovascular markers in patients with active rheumatoid arthritis: a pilot study

Short Communication

Mevalonate kinase genotype in children with recurrent fevers and high serum IgD level

ACKNOWLEDGEMENT TO REFEREES

Referees 2012

Short Communication

The osteocalcin gene rs1800247 polymorphism in Kashubian population

Original Article

Systemic involvements and preferred treatments in a large cohort of Behçet’s disease

Short Communication

Association of interleukin-18 and systemic lupus erythematosus
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits