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Investigational New Drugs

Issue 5/2010

Content (20 Articles)

PRECLINICAL STUDIES

Nelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib

Ansgar Brüning, Petra Burger, Marianne Vogel, Andrea Gingelmaier, Klaus Friese, Alexander Burges

PRECLINICAL STUDIES

Effect of a Vitamin D3 derivative (B3CD) with postulated anti-cancer activity in an ovarian cancer animal model

Thilo S. Lange, Ashley R. Stuckey, Katina Robison, Kyu Kwang Kim, Rakesh K. Singh, Christina A. Raker, Laurent Brard

PRECLINICAL STUDIES

An in vitro study, evaluating the effect of sunitinib and/or lapatinib on two glioma cell lines

Efstathia Giannopoulou, Konstantinos Dimitropoulos, Andreas A. Argyriou, Angelos K. Koutras, Fotinos Dimitrakopoulos, Haralabos P. Kalofonos

PRECLINICAL STUDIES

Development of a new fully human anti-CD20 monoclonal antibody for the treatment of B-cell malignancies

Gadi Gazit Bornstein, Christophe Quéva, Mohammad Tabrizi, Anne van Abbema, Carlos Chavez, Ping Wang, Orit Foord, Kiran Ahluwalia, Naomi Laing, Sandhya Raja, Shenghua Wen, Larry L. Green, Xiaodong Yang, Carl Webster, Ross Stewart, David Blakey

PRECLINICAL STUDIES

The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells

Sharon A. Mason, Sarah-Jane Cozzi, Carly J. Pierce, Sandra J. Pavey, Peter G. Parsons, Glen M. Boyle

PRECLINICAL STUDIES

Synthesis and biological properties of oxazolinodaunorubicin—a new derivative of daunorubicin with a modified daunosamine moiety

Malgorzata Lukawska, Joanna Wietrzyk, Adam Opolski, Janusz Oszczapowicz, Irena Oszczapowicz

PRECLINICAL STUDIES

Studies on the neuroprotective role of Piper longum in C6 glioma induced rats

Umadevi Subramanian, Sharmila Poongavanam, A. J. Vanisree

PHASE I STUDIES

A phase I trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer

Stacy Moulder, Navneet Dhillon, Chaan Ng, David Hong, Jennifer Wheler, Aung Naing, Susan Tse, Amy La Paglia, Robert Dorr, Evan Hersh, Michelle Boytim, Razelle Kurzrock

PHASE I STUDIES

Intravenous administration of Reolysin®, a live replication competent RNA virus is safe in patients with advanced solid tumors

Radharani Gollamudi, Mohammad H. Ghalib, Kavita K. Desai, Imran Chaudhary, Benny Wong, Mark Einstein, Matthew Coffey, George M. Gill, Karl Mettinger, John M. Mariadason, Sridhar Mani, Sanjay Goel

PHASE I STUDIES

A phase I pharmacokinetic and pharmacodynamic study of CKD-732, an antiangiogenic agent, in patients with refractory solid cancer

Sang Joon Shin, Hei-Cheul Jeung, Joong Bae Ahn, Sun Young Rha, Jae Kyung Roh, Kyung Soo Park, Dal-Hyun Kim, Chin Kim, Hyun Cheol Chung

PHASE II STUDIES

Phase II study of gemcitabine in combination with vinorelbine versus gemcitabine followed by vinorelbine for metastatic breast cancer

In Hae Park, Jungsil Ro, Keun Seok Lee, Shi Nae Kim, Young Ho Yun, Byung Ho Nam

PHASE II STUDIES

Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma

Jennifer Wu, Charles Henderson, Lynn Feun, Peter Van Veldhuizen, Philip Gold, Hui Zheng, Theresa Ryan, Lawrence S. Blaszkowsky, HaoBin Chen, Max Costa, Barry Rosenzweig, MaryLynn Nierodzik, Howard Hochster, Franco Muggia, Giovanni Abbadessa, Jonathan Lewis, Andrew X. Zhu

PHASE II STUDIES

Phase II study of sunitinib malate in head and neck squamous cell carcinoma

Nicholas W. Choong, Mark Kozloff, David Taber, H. Shawn Hu, James Wade III, Percy Ivy, Theodore G. Karrison, Allison Dekker, Everett E. Vokes, Ezra E. W. Cohen

PRECLINICAL STUDIES

Oral metronomic cyclophosphamide in elderly with metastatic melanoma

Estelle Borne, Eve Desmedt, Alain Duhamel, Xavier Mirabel, Véronique Dziwniel, Cyril Maire, Valérie Florin, Véronique Martinot, Nicolas Penel, Sophie Vercambre-Darras, Laurent Mortier

SHORT REPORT

Sunitinib inducing tumor lysis syndrome in a patient treated for renal carcinoma

Judith Michels, Nathalie Lassau, Marine Gross-Goupil, Christophe Massard, Arnaud Mejean, Bernard Escudier

SHORT REPORT

Anti-tumor effects of nitrosylcobalamin against spontaneous tumors in dogs

Joseph A. Bauer, Gerald Frye, Anne Bahr, Jennifer Gieg, Peter Brofman

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
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