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Investigational New Drugs

Issue 3/2010

Content (20 Articles)

PRECLINICAL STUDIES

Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo

Qiang Tan, Jing Li, Han-wei Yin, Li-hui Wang, Wan-chen Tang, Fang Zhao, Xin-min Liu, Hui-hui Zeng

PRECLINICAL STUDIES

Regulation of cell growth through cell cycle arrest and apoptosis in HPV 16 positive human cervical cancer cells by tea polyphenols

Madhulika Singh, Shilpa Tyagi, Kulpreet Bhui, Sahdeo Prasad, Yogeshwer Shukla

PRECLINICAL STUDIES

FBA-TPQ, a novel marine-derived compound as experimental therapy for prostate cancer

Feng Wang, Scharri J. Ezell, Yong Zhang, Wei Wang, Elizabeth R. Rayburn, Dwayaja H. Nadkarni, Srinivasan Murugesan, Sadanandan E. Velu, Ruiwen Zhang

Open Access PRECLINICAL STUDIES

Development and characterization of CD22-targeted pegylated-liposomal doxorubicin (IL-PLD)

Robert T. O’Donnell, Shiloh M. Martin, Yunpeng Ma, William C. Zamboni, Joseph M. Tuscano

PRECLINICAL STUDIES

Screening of a PKC ζ-specific kinase inhibitor PKCzI257.3 which inhibits EGF-induced breast cancer cell chemotaxis

Jing Wu, Baogang Zhang, Min Wu, Hongyan Li, Ruifang Niu, Guoguang Ying, Ning Zhang

PRECLINICAL STUDIES

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

K. Dredge, E. Hammond, K. Davis, C. P. Li, L. Liu, K. Johnstone, P. Handley, N. Wimmer, T. J. Gonda, A. Gautam, V. Ferro, I. Bytheway

PRECLINICAL STUDIES

Suppression of in vivo tumor growth by using a biodegradable thermosensitive hydrogel polymer containing chemotherapeutic agent

Mi Kyung Kwak, Keun Hur, Ji Eun Yu, Tae Su Han, Kazuyoshi Yanagihara, Woo Ho Kim, Sun Mi Lee, Soo-Chang Song, Han-Kwang Yang

PRECLINICAL STUDIES

Strong inhibition of replicative DNA synthesis in the developing rat cerebral cortex and glioma cells by roscovitine

Juan Sebastian Yakisich, Marina Fernanda Vita, Åke Siden, Deborah Ruth Tasat, Mabel Cruz

PRECLINICAL STUDIES

MMPT: a thiazolidin compound inhibits the growth of lung cancer H1792 cells via Fas-mediated and caspase-dependent apoptosis pathway

Yun-feng Zhao, Xiu-lan Li, Yu-xi Sun, Wen Niu, Zun-li Hu, Lin Lin, Qing-Zhong Kong

Open Access PRECLINICAL STUDIES

Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response

Brigette B.Y. Ma, Vivian W.Y. Lui, Fan Fong Poon, S.C. Cesar Wong, Ka Fai To, Elaine Wong, Honglin Chen, Kwok Wai Lo, Qian Tao, Anthony T.C. Chan

PHASE I STUDIES

Phase I, pharmacokinetic study of temsirolimus administered orally to patients with advanced cancer

Jan C. Buckner, Bahram Forouzesh, Charles Erlichman, Manuel Hidalgo, Joseph P. Boni, Gary Dukart, Anna Berkenblit, Eric K. Rowinsky

PHASE II STUDIES

Pilot study of irinotecan/oxalipltin (IROX) combination chemotherapy for patients with gemcitabine- and 5-fluorouracil- refractory pancreatic cancer

Sung Yong Oh, Hyun Jin Kim, Tae Hyo Kim, Gyeong-Won Lee, Hoon Gu Kim, Chi-Young Jeong, Hyuk-Chan Kwon, Jung Hun Kang

SHORT REPORT

Acute left ventricular dysfunction induced by a panHER and VEGFR tyrosine kinase inhibitor in a phase I trial

Rastislav Bahleda, Christophe Massard, Jean-Charles Soria, Hassan Izzedine, Ariel Cohen, Stéphane Ederhy

REVIEW

Safety and efficacy of panitumumab following cetuximab: retrospective review of the Memorial Sloan-Kettering experience

Derek G. Power, Manish A. Shah, Timothy R . Asmis, Joaquin J . Garcia, Nancy E. Kemeny

Open Access Erratum

Erratum to: Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response

Brigette B. Y. Ma, Vivian W. Y. Lui, Fan Fong Poon, S. C. Cesar Wong, Ka Fai To, Elaine Wong, Honglin Chen, Kwok Wai Lo, Qian Tao, Margaret Heung Ling Ng, Suk Hang Cheng, Anthony T. C. Chan

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine