Skip to main content
Top

Investigational New Drugs

Issue 2/2008

Content (11 Articles)

Preclinical Studies

Atypical cytostatic mechanism of N-1-sulfonylcytosine derivatives determined by in vitro screening and computational analysis

Fran Supek, Marijeta Kralj, Marko Marjanović, Lidija Šuman, Tomislav Šmuc, Irena Krizmanić, Biserka Žinić

Preclinical Studies

NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2

Miguel Muñoz, Marisa Rosso, Francisco J Aguilar, Miguel A González-Moles, Maximino Redondo, Francisco Esteban

PRECLINICAL STUDIES

Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat

Qi-Biao Su, Fan He, Xue-Ding Wang, Su Guan, Zhi-Yong Xie, Lai-You Wang, Yu-Jing Lu, Lian-Quan Gu, Zhi-Shu Huang, Xiao Chen, Min Huang, Shu-Feng Zhou

PHASE I STUDIES

Phase I study of a novel pro-apoptotic drug R-etodolac in patients with B-cell chronic lymphocytic leukemia

Markus Jensen, Andreas Engert, Florian Weissinger, Wolfgang Knauf, Eva Kimby, Christopher Poynton, Ira Anton Oliff, Mathias J. Rummel, Anders Österborg

PHASE I STUDIES

Phase I study of a 3-drug regimen of gemcitabine/cisplatin/pemetrexed in patients with metastatic transitional cell carcinoma of the urothelium

Thomas E. Hutson, Svetislava Vukelja, Daniel Atienza, Sanjay Awasthi, Robert Delaune, Margaret Deutsch, Philip Y. Dien, Thomas F. Gregory, Michael J. Kolodziej, Joseph J. Muscato, Robert N. Raju, Robert L. Ruxer Jr, Stephanie Mull, Des Ilegbodu, Karen Hood, Steven Nicol, William Berry

PHASE I STUDIES

Phase I clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors

Patricia M. LoRusso, Shirish M. Gadgeel, Antoinette Wozniak, Alan J. Barge, Helen K. Jones, Zachary S. DelProposto, Pamela A. DeLuca, Jeffrey L. Evelhoch, Scott A. Boerner, Catherine Wheeler

Phase II Studies

A multicenter phase II trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells

Brigette Ma, Boon Cher Goh, Eng Huat Tan, Kwok Chi Lam, Ross Soo, Swan Swan Leong, Ling Zhi Wang, Frankie Mo, Anthony T. C. Chan, Benny Zee, Tony Mok

PHASE II STUDIES

The “old drug” dacarbazine as a second/third line chemotherapy in advanced soft tissue sarcomas

Paolo Andrea Zucali, Alexia Bertuzzi, Hector Jose Soto Parra, Elisabetta Campagnoli, Vittorio Quagliuolo, Armando Santoro

PHASE II STUDIES

A phase II trial of doxorubicin and interferon alpha 2b in advanced, non-medullary thyroid cancer

Athanassios Argiris, Sanjiv S. Agarwala, Michalis V. Karamouzis, Lynn A. Burmeister, Sally E. Carty

Preclinical Studies

Topical henna for capecitabine induced hand–foot syndrome

Idris Yucel, Gonullu Guzin

SHORT REPORT

A phase I–II study of oblimersen sodium (G3139, Genasense) in combination with doxorubicin in advanced hepatocellular carcinoma (NCI # 5798)

J. J. Knox, X. E. Chen, R. Feld, M. Nematollahi, R. Cheiken, G. Pond, J. A. Zwiebel, S. Gill, M. Moore

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine