Issue 1/2017
Content (15 Articles)
4-methylumbelliferone and imatinib combination enhances senescence induction in chronic myeloid leukemia cell lines
Silvina Laura Lompardía, Mariángeles Díaz, Daniela Laura Papademetrio, Matías Pibuel, Élida Álvarez, Silvia Elvira Hajos
Targeting the protein ubiquitination machinery in melanoma by the NEDD8-activating enzyme inhibitor pevonedistat (MLN4924)
Kit Man Wong, Lindsey N. Micel, Heather M. Selby, Aik Choon Tan, Todd M. Pitts, Stacey M. Bagby, Anna Spreafico, Peter J. Klauck, Stephen J. Blakemore, Peter F. Smith, Alice McDonald, Allison Berger, John J. Tentler, S. Gail Eckhardt
The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma
Augusto Faria Andrade, Kleiton Silva Borges, Veridiana Kiill Suazo, Lenisa Geron, Carolina Alves Pereira Corrêa, Angel Mauricio Castro-Gamero, Elton José Rosas de Vasconcelos, Ricardo Santos de Oliveira, Luciano Neder, José Andres Yunes, Simone dos Santos Aguiar, Carlos Alberto Scrideli, Luiz Gonzaga Tone
Phase Ia/Ib study of the pan-class I PI3K inhibitor pictilisib (GDC-0941) administered as a single agent in Japanese patients with solid tumors and in combination in Japanese patients with non-squamous non-small cell lung cancer
Noboru Yamamoto, Yutaka Fujiwara, Kenji Tamura, Shunsuke Kondo, Satoru Iwasa, Yuko Tanabe, Atsushi Horiike, Noriko Yanagitani, Satoru Kitazono, Michiyasu Inatani, Jun Tanaka, Makoto Nishio
A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors
Alex A. Adjei, Patricia LoRusso, Antoni Ribas, Jeffrey A. Sosman, Anna Pavlick, Grace K. Dy, Xiaofei Zhou, Esha Gangolli, Michelle Kneissl, Stephanie Faucette, Rachel Neuwirth, Viviana Bózon
Incidence of infusion reactions to anti-neoplastic agents in early phase clinical trials: The MD Anderson Cancer Center experience
Manojkumar Bupathi, Joud Hajjar, Stacie Bean, Siqing Fu, David Hong, Daniel Karp, Bettzy Stephen, Kenneth Hess, Funda Meric-Bernstam, Aung Naing
A phase 1 study combining the HER3 antibody seribantumab (MM-121) and cetuximab with and without irinotecan
James M. Cleary, Autumn J. McRee, Geoffrey I. Shapiro, Sara M. Tolaney, Bert H. O’Neil, Jeffrey D. Kearns, Sara Mathews, Rachel Nering, Gavin MacBeath, Akos Czibere, Sunil Sharma, W. Michael Korn
Predictive factors of renal toxicities related to anti-VEGFR multikinase inhibitors in phase 1 trials
Emilie Boissier, Olivier Mir, Antoine Hollebecque, Hassan Izzedine, Stéphane Ederhy, Anas Gazzah, Rastislav Bahleda, Christophe Massard, Isabelle Macquin-Mavier, Christophe Tournigand, Jean-Philippe Spano, Jean-Charles Soria, Benoît Rousseau
Phase 1b study of orteronel in postmenopausal women with hormone-receptor positive (HR+) metastatic breast cancer
Murtuza Rampurwala, Kari B. Wisinski, Mark E. Burkard, Sima Ehsani, Ruth M. O’Regan, Lakeesha Carmichael, KyungMann Kim, Jill Kolesar, Amye J. Tevaarwerk
A phase I trial investigating pulsatile erlotinib in combination with gemcitabine and oxaliplatin in advanced biliary tract cancers
Laura W. Goff, Dana B. Cardin, Jennifer G. Whisenant, Liping Du, Tatsuki Koyama, Kimberly B. Dahlman, Safia N. Salaria, Ruth T. Young, Kristen K. Ciombor, Jill Gilbert, Stephen James Smith, Emily Chan, Jordan Berlin
Osimertinib-induced interstitial lung disease after treatment with anti-PD1 antibody
Nobuaki Mamesaya, Hirotsugu Kenmotsu, Mineo Katsumata, Takashi Nakajima, Masahiro Endo, Toshiaki Takahashi
Evaluating the role of phase I expansion cohorts in oncologic drug development
Robin E. Norris, Mohadese Behtaj, Pingfu Fu, Afshin Dowlati
A photodynamic bifunctional conjugate for prostate cancer: an in vitro mechanistic study
Valentina Rapozzi, Greta Varchi, Emilia Della Pietra, Claudia Ferroni, Luigi E. Xodo
Erratum to: The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma
Augusto Faria Andrade, Kleiton Silva Borges, Veridiana Kiill Suazo, Lenisa Geron, Carolina Alves Pereira Corrêa, Angel Mauricio Castro-Gamero, Elton José Rosas de Vasconcelos, Ricardo Santos de Oliveira, Luciano Neder, José Andres Yunes, Simone dos Santos Aguiar, Carlos Alberto Scrideli, Luiz Gonzaga Tone