Published in:
01-04-2020 | Insulins | Original Article
Mild hyperamylasemia in type 1 diabetic children without diabetic ketoacidosis is associated with C-peptide
Published in: International Journal of Diabetes in Developing Countries | Issue 2/2020
Login to get accessAbstract
Background
The aim of this study is to investigate the relationship between plasma amylase concentration and C-peptide level in type 1 diabetic and healthy children.
Methods
The cross-sectional study involved 31 Chinese type 1 diabetic children without complications and 107 healthy control subjects. Clinical examination and laboratory examinations were assessed for all participants.
Results
Significantly higher amylase concentrations were measured in type 1 diabetic children than in controls (102.8 U/l vs. 70.2 U/l, respectively; p < 0.001), but plasma lipase was significantly lower in type 1 diabetic children. The mean concentrations of pancreatic amylase were also lower in type 1 diabetic children than controls, but this difference did not reach statistical significance. Plasma amylase was significantly negatively correlated with lipase and C-peptide concentrations and was significantly positively correlated with both blood glucose and glycemic control. There were also negative correlations among blood glucose, glycemic control, and plasma lipase and an interaction between plasma lipase and C-peptide concentrations. Pancreatic amylase concentration was significantly correlated with the dose of insulin administered to the type 1 diabetic children. A total of 22.1% of the type 1 diabetic children were temporarily positive for urine protein but did not have diabetic nephropathy.
Conclusions
It is recommended that clinicians perform amylase assays to assess the extreme low level of C-peptide which is difficult to detect in children with T1DM.