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Open Access 01-12-2020 | Insomnia | Research article

Aneurysmal subarachnoid haemorrhage: effect of CRHR1 genotype on fatigue and depression

Authors: Artur Vetkas, Ele Prans, Sulev Kõks, Tõnu Rätsep, Toomas Asser

Published in: BMC Neurology | Issue 1/2020

Abstract

Background

Emotional health disturbances are common after aneurysmal subarachnoid hemorrhage (aSAH) and their causes are largely unexplored. Corticotropin-releasing hormone receptor 1 (CRHR1) is a key factor in stress reactivity and development of mental health disturbances after adverse life-events.

Methods

We explore the effect of CRHR1 genotype on mental health after aSAH in a retrospective cohort study. One hundred twenty-five patients have been assessed using EST-Q mental health questionnaire. Genotyping of CRHR1 single nucleotide polymorphisms (SNP-s) was performed (Rs7209436, Rs110402, Rs242924).

Results

Fatigue was present in almost half of aSAH patients, depression and anxiety in one-third. There was a high prevalence of insomnia and panic complaints. Rs110402 minor allele decreased the risk of depression (OR = 0.25, p = 0.027 for homozygotes). Depression was present in 14% vs 41% in minor and major allele homozygotes, respectively. Rs110402, Rs242924 and Rs7209436 minor alleles and TAT-haplotype, formed by them, were protective against fatigue. After Bonferroni correction only the association of Rs110402 with fatigue remained statistically significant (OR = 0.21, p = 0.006 for minor allele homozygotes). Results remained statistically significant when adjusted for gender, admission state, age and time from aSAH. In multiple regression analysis occurrence of fatigue was dependent on anxiety, modified Rankin score and Rs110402 genotype (R² = 0.34, p < 0.001).

Conclusions

CRHR1 minor genotype was associated with a lower risk of fatigue and depression after aSAH. Genetic predisposition to mental health disturbances associated with negative life-events could be a risk factor for fatigue and depression after aSAH and selected patients might benefit from advanced counselling in the recovery phase.

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Title: Aneurysmal subarachnoid haemorrhage: effect of CRHR1 genotype on fatigue and depression
Authors: Artur Vetkas
Ele Prans
Sulev Kõks
Tõnu Rätsep
Toomas Asser
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Insomnia
Subarachnoid Hemorrhage
Mood Disorders
Aneurysm
Aneurysm
Subarachnoid Hemorrhage
Affective Disorder
Anxiety
Fatigue
Published in: BMC Neurology / Issue 1/2020
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-020-01727-y

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Aneurysmal subarachnoid haemorrhage: effect of CRHR1 genotype on fatigue and depression

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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