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Published in: Cost Effectiveness and Resource Allocation 1/2010

Open Access 01-12-2010 | Research

Burden of disease and costs of aneurysmal subarachnoid haemorrhage (aSAH) in the United Kingdom

Authors: Oliver Rivero-Arias, Alastair Gray, Jane Wolstenholme

Published in: Cost Effectiveness and Resource Allocation | Issue 1/2010

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Abstract

Background

To estimate life years and quality-adjusted life years (QALYs) lost and the economic burden of aneurysmal subarachnoid haemorrhage (aSAH) in the United Kingdom including healthcare and non-healthcare costs from a societal perspective.

Methods

All UK residents in 2005 with aSAH (International Classification of Diseases 10th revision (ICD-10) code I60). Sex and age-specific abridged life tables were generated for a general population and aSAH cohorts. QALYs in each cohort were calculated adjusting the life tables with health-related quality of life (HRQL) data. Healthcare costs included hospital expenditure, cerebrovascular rehabilitation, primary care and community health and social services. Non-healthcare costs included informal care and productivity losses arising from morbidity and premature death.

Results

A total of 80,356 life years and 74,807 quality-adjusted life years were estimated to be lost due to aSAH in the UK in 2005. aSAH costs the National Health Service (NHS) £168.2 million annually with hospital inpatient admissions accounting for 59%, community health and social services for 18%, aSAH-related operations for 15% and cerebrovascular rehabilitation for 6% of the total NHS estimated costs. The average per patient cost for the NHS was estimated to be £23,294. The total economic burden (including informal care and using the human capital method to estimate production losses) of a SAH in the United Kingdom was estimated to be £510 million annually.

Conclusion

The economic and disease burden of aSAH in the United Kingdom is reported in this study. Decision-makers can use these results to complement other information when informing prevention policies in this field and to relate health care expenditures to disease categories.
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Literature
1.
go back to reference van Gijn J, Kerr RS, Rinkel GJ: Subarachnoid haemorrhage. Lancet 2007, 369: 306–318. 10.1016/S0140-6736(07)60153-6PubMedCrossRef van Gijn J, Kerr RS, Rinkel GJ: Subarachnoid haemorrhage. Lancet 2007, 369: 306–318. 10.1016/S0140-6736(07)60153-6PubMedCrossRef
2.
go back to reference Suarez JI, Tarr RW, Selman WR: Aneurysmal subarachnoid hemorrhage. New England Journal of Medicine 2006, 354: 387–396. 10.1056/NEJMra052732PubMedCrossRef Suarez JI, Tarr RW, Selman WR: Aneurysmal subarachnoid hemorrhage. New England Journal of Medicine 2006, 354: 387–396. 10.1056/NEJMra052732PubMedCrossRef
3.
go back to reference Wilby MJ, Sharp M, Whitfield PC, Hutchinson PJ, Menon DK, Kirkpatrick PJ: Cost-effective outcome for treating poor-grade subarachnoid hemorrhage. Stroke 2003, 34: 2508–2511. 10.1161/01.STR.0000089922.94684.13PubMedCrossRef Wilby MJ, Sharp M, Whitfield PC, Hutchinson PJ, Menon DK, Kirkpatrick PJ: Cost-effective outcome for treating poor-grade subarachnoid hemorrhage. Stroke 2003, 34: 2508–2511. 10.1161/01.STR.0000089922.94684.13PubMedCrossRef
4.
go back to reference Roos YBWE, Dijkgraaf MGW, Albrecht KW, Beenen LFM, Groen RJM, de Haan RJ, Vermeulen M: Direct costs of modern treatment of aneurysmal subarachnoid hemorrhage in the first year after diagnosis. Stroke 2002, 33: 1595–1599. 10.1161/01.STR.0000016401.49688.2FPubMedCrossRef Roos YBWE, Dijkgraaf MGW, Albrecht KW, Beenen LFM, Groen RJM, de Haan RJ, Vermeulen M: Direct costs of modern treatment of aneurysmal subarachnoid hemorrhage in the first year after diagnosis. Stroke 2002, 33: 1595–1599. 10.1161/01.STR.0000016401.49688.2FPubMedCrossRef
5.
go back to reference Wolstenholme J, Rivero-Arias O, Gray A, Molyneux AJ, Kerr RS, Yarnold JA, Sneade M, International Subarachnoid Aneurysm Trial (ISAT): Collaborative Group Treatment pathways, resource use, and costs of endovascular coiling versus surgical clipping after aSAH. Stroke 2008, 39: 111–119. 10.1161/STROKEAHA.107.482570PubMedCrossRef Wolstenholme J, Rivero-Arias O, Gray A, Molyneux AJ, Kerr RS, Yarnold JA, Sneade M, International Subarachnoid Aneurysm Trial (ISAT): Collaborative Group Treatment pathways, resource use, and costs of endovascular coiling versus surgical clipping after aSAH. Stroke 2008, 39: 111–119. 10.1161/STROKEAHA.107.482570PubMedCrossRef
6.
go back to reference Lopez AD, et al (Eds): Global Burden of Disease and Risk Factors New York: OUP and WHO; 2006. Lopez AD, et al (Eds): Global Burden of Disease and Risk Factors New York: OUP and WHO; 2006.
7.
go back to reference Murray CJL, Lopez AD (Eds): Global Comparative Assessments in the Health Sector Geneva: World Health Organization; 1994. Murray CJL, Lopez AD (Eds): Global Comparative Assessments in the Health Sector Geneva: World Health Organization; 1994.
8.
go back to reference Clabaugh G, Ward MM: Cost-of-illness studies in the United States: A systematic review of methodologies used for direct cost. Value in Health 2008, 11: 13–21.PubMedCrossRef Clabaugh G, Ward MM: Cost-of-illness studies in the United States: A systematic review of methodologies used for direct cost. Value in Health 2008, 11: 13–21.PubMedCrossRef
9.
go back to reference Luengo-Fernandez R, Leal J, Gray A, Petersen S, Rayner M: Cost of cardiovascular diseases in the United Kingdom. Heart 2006, 92: 1384–1389. 10.1136/hrt.2005.072173PubMedCentralPubMedCrossRef Luengo-Fernandez R, Leal J, Gray A, Petersen S, Rayner M: Cost of cardiovascular diseases in the United Kingdom. Heart 2006, 92: 1384–1389. 10.1136/hrt.2005.072173PubMedCentralPubMedCrossRef
10.
go back to reference Rothwell PM, Coull AJ, Silver LE, Fairhead JF, Giles MF, Lovelock CE, Redgrave JN, Bull LM, Welch SJ, Cuthbertson FC, Binney LE, Gutnikov SA, Anslow P, Banning AP, Mant D, Mehta Z, Oxford VS: Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet 2005, 366: 1773–1783. 10.1016/S0140-6736(05)67702-1PubMedCrossRef Rothwell PM, Coull AJ, Silver LE, Fairhead JF, Giles MF, Lovelock CE, Redgrave JN, Bull LM, Welch SJ, Cuthbertson FC, Binney LE, Gutnikov SA, Anslow P, Banning AP, Mant D, Mehta Z, Oxford VS: Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet 2005, 366: 1773–1783. 10.1016/S0140-6736(05)67702-1PubMedCrossRef
11.
13.
go back to reference Department of Health: Hospital Episodes Statistics, England: Financial Year 2005–06. London: Department of Health; 2006. Department of Health: Hospital Episodes Statistics, England: Financial Year 2005–06. London: Department of Health; 2006.
14.
go back to reference Department of Health: Burden of Disease: A Discussion Document. London: NHS Executive; 1996. Department of Health: Burden of Disease: A Discussion Document. London: NHS Executive; 1996.
15.
go back to reference McCormick A, Fleming D, Charlton J: Morbidity statistics from general practice: fourth national study 1991–92. London: HMSO; 1995. McCormick A, Fleming D, Charlton J: Morbidity statistics from general practice: fourth national study 1991–92. London: HMSO; 1995.
16.
go back to reference Babb P, et al (Eds): Social Trends no 36 London: Office for National Statistics; 2006. Babb P, et al (Eds): Social Trends no 36 London: Office for National Statistics; 2006.
17.
go back to reference Molyneux AJ, Kerr RSC, Yu LM, Clarke M, Sneade M, Yarnold JA, Sandercock P: International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 2005, 366: 809–817. 10.1016/S0140-6736(05)67214-5PubMedCrossRef Molyneux AJ, Kerr RSC, Yu LM, Clarke M, Sneade M, Yarnold JA, Sandercock P: International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 2005, 366: 809–817. 10.1016/S0140-6736(05)67214-5PubMedCrossRef
18.
go back to reference Office for National Statistics: Mortality Statistics. London: Office for National Statistics; 2005. Office for National Statistics: Mortality Statistics. London: Office for National Statistics; 2005.
19.
go back to reference Muennig PA, Gold MR: Using the years-of-healthy-life measure to calculate QALYs. American Journal of Preventive Medicine 2001, 20: 35–39. 10.1016/S0749-3797(00)00261-0PubMedCrossRef Muennig PA, Gold MR: Using the years-of-healthy-life measure to calculate QALYs. American Journal of Preventive Medicine 2001, 20: 35–39. 10.1016/S0749-3797(00)00261-0PubMedCrossRef
20.
go back to reference EuroQol Group EuroQol - a new facility for the measurement of health-related quality of life Health Policy 1990, 16: 199–208. 10.1016/0168-8510(90)90421-9 EuroQol Group EuroQol - a new facility for the measurement of health-related quality of life Health Policy 1990, 16: 199–208. 10.1016/0168-8510(90)90421-9
21.
go back to reference Kind P, Hardman G, Macran S: UK population norms for EQ-5D. Discussion paper 172: Centre for Health Economics, University of York, UK 1999. Kind P, Hardman G, Macran S: UK population norms for EQ-5D. Discussion paper 172: Centre for Health Economics, University of York, UK 1999.
23.
go back to reference Curtis L, Netten A: Unit costs of health and social care. University of Kent at Canterbury: Personal Social Services Research Unit; 2006. Curtis L, Netten A: Unit costs of health and social care. University of Kent at Canterbury: Personal Social Services Research Unit; 2006.
24.
go back to reference Clinical Effectiveness Unit: National Study of Subarachnoid Haemorrhage. London: The Royal College of Surgeons of England and the London School of Hygiene and Tropical Medicine; 2006. Clinical Effectiveness Unit: National Study of Subarachnoid Haemorrhage. London: The Royal College of Surgeons of England and the London School of Hygiene and Tropical Medicine; 2006.
25.
go back to reference Comas-Herrera A, Wittenberg R, Costa-Font J, Gori C, Di Maio A, Patxot C, Pickard L, Pozzi A, Rothgang H: Future long-term care expenditure in Germany, Spain, Italy and the United Kingdom. Ageing & Society 2006, 26: 285–302.CrossRef Comas-Herrera A, Wittenberg R, Costa-Font J, Gori C, Di Maio A, Patxot C, Pickard L, Pozzi A, Rothgang H: Future long-term care expenditure in Germany, Spain, Italy and the United Kingdom. Ageing & Society 2006, 26: 285–302.CrossRef
26.
go back to reference Rowlands O: General household survey 1995, supplement A: informal carers. London: The Stationary Office; 1998. Rowlands O: General household survey 1995, supplement A: informal carers. London: The Stationary Office; 1998.
27.
go back to reference Green H: General household survey 1985, supplement A: informal carers. London: HMSO; 1988. Green H: General household survey 1985, supplement A: informal carers. London: HMSO; 1988.
29.
go back to reference Office of National Statistics: Annual Survey of Hours and Earnings. London: Office for National Statistics; 2005. Office of National Statistics: Annual Survey of Hours and Earnings. London: Office for National Statistics; 2005.
31.
go back to reference Pritchard C, Sculpher M: Productivity costs: Principles and practice in economic evaluation. London: Office of Health Economics; 2000. Pritchard C, Sculpher M: Productivity costs: Principles and practice in economic evaluation. London: Office of Health Economics; 2000.
32.
go back to reference Koopmanschap MA, van Ineveld BM: Towards a new approach for estimating indirect costs of disease. Soc Sci Med 1992, 34: 1005–1010. 10.1016/0277-9536(92)90131-9PubMedCrossRef Koopmanschap MA, van Ineveld BM: Towards a new approach for estimating indirect costs of disease. Soc Sci Med 1992, 34: 1005–1010. 10.1016/0277-9536(92)90131-9PubMedCrossRef
33.
go back to reference Leal J, Luengo-Fernandez R, Gray A, Petersen S, Rayner M: Economic burden of cardiovascular diseases in the enlarged European Union. European Heart Journal 2006, 27: 1610–1619. 10.1093/eurheartj/ehi733PubMedCrossRef Leal J, Luengo-Fernandez R, Gray A, Petersen S, Rayner M: Economic burden of cardiovascular diseases in the enlarged European Union. European Heart Journal 2006, 27: 1610–1619. 10.1093/eurheartj/ehi733PubMedCrossRef
34.
go back to reference Katati MJ, Santiago-Ramajo S, Perez-Garcia M, Meersmans-Sanchez JM, Vilar-Lopez R, Coin-Mejias MA, Caracuel-Romero A, rjona-Moron V: Description of quality of life and its predictors in patients with aneurysmal subarachnoid hemorrhage. Cerebrovascular Diseases 2007, 24: 66–73. 10.1159/000103118PubMedCrossRef Katati MJ, Santiago-Ramajo S, Perez-Garcia M, Meersmans-Sanchez JM, Vilar-Lopez R, Coin-Mejias MA, Caracuel-Romero A, rjona-Moron V: Description of quality of life and its predictors in patients with aneurysmal subarachnoid hemorrhage. Cerebrovascular Diseases 2007, 24: 66–73. 10.1159/000103118PubMedCrossRef
35.
go back to reference Ware JEJ: SF-36 health survey update. Spine 2000, 25: 3130–3139. 10.1097/00007632-200012150-00008PubMedCrossRef Ware JEJ: SF-36 health survey update. Spine 2000, 25: 3130–3139. 10.1097/00007632-200012150-00008PubMedCrossRef
37.
go back to reference Akobundu E, Ju J, Blatt L, Mullins CD: Cost-of-illness studies: A review of current methods. PharmacoEconomics 2006, 24: 869–890. 10.2165/00019053-200624090-00005PubMedCrossRef Akobundu E, Ju J, Blatt L, Mullins CD: Cost-of-illness studies: A review of current methods. PharmacoEconomics 2006, 24: 869–890. 10.2165/00019053-200624090-00005PubMedCrossRef
Metadata
Title
Burden of disease and costs of aneurysmal subarachnoid haemorrhage (aSAH) in the United Kingdom
Authors
Oliver Rivero-Arias
Alastair Gray
Jane Wolstenholme
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Cost Effectiveness and Resource Allocation / Issue 1/2010
Electronic ISSN: 1478-7547
DOI
https://doi.org/10.1186/1478-7547-8-6

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