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Open Access 01-12-2022 | Insomnia | Research

The presence and co-incidence of geriatric syndromes in older patients with mild-moderate Lewy body dementia

Authors: Jinghuan Gan, Zhichao Chen, Shuai Liu, Zhihong Shi, Yiming Liu, Xiao-Dan Wang, Chunyan Liu, Yong Ji

Published in: BMC Neurology | Issue 1/2022

Abstract

Introduction

Geriatric symptoms are common in dementia cases, while few studies have focused on these symptoms in Lewy body dementia (LBD). The purpose of this study is to investigate the distributions of Apolipoprotein E (APOE) ε4 and geriatric symptoms, and explore their associaitons in Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD).

Methods

A retrospective study with 185 mild-moderate probable DLB (n = 93) and PDD (n = 92) patients was assigned. Demographic and clinical characteristics, neuropsychological assessments, and APOE genotypes were recorded. Description, correlation and logistic regression models were used to analyze the presence of geriatric symptom complaints and their associations with APOE ε4.

Results

DLB patients displayed more frequency of fluctuating cognition, visual hallucination, rapid eye movement sleep behavior disorder, delusion, depression, anxiety, apathy, and loss of appetite, whereas the PDD cases had constipation, fear of falling, and insomnia more frequently. The APOE ε4 allele was more common in DLB than PDD (29.9% vs. 7.0%, p < 0.001), and the patients with DLB + APOE ε4 (+) were presented more delusions (p = 0.005) and apathy (p = 0.007) than patients with PDD + APOE ε4 (+). We also found that the APOE ε4 allele was significantly associated with hyperhidrosis (OR = 3.472, 95%CI: 1.082–11.144, p = 0.036) and depression (OR = 3.002, 95%CI: 1.079–8.353, p = 0.035) in DLB patients, while there were no significant associations between APOE ε4 allele and the age at visit, the age at onset, scores of MDS-UPDRS III, H&Y stage, ADL, MMSE, MOCA and NPI, as well as the presences of fluctuating cognition, VH, parkinsonism and RBD in both groups.

Conclusion

The presence and co-incidence of geriatric symptoms are common in patients with mild-moderate LBD. The presence of APOE ε4 allele is associated with hyperhidrosis and depression, but not global cognition, activitives of daily life, motor function and other neuropsychitric symptoms in DLB. These findings improve the awareness of geriatric symptoms, and contribute to the healthcare management of mild-moderate DLB and PDD.

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Title: The presence and co-incidence of geriatric syndromes in older patients with mild-moderate Lewy body dementia
Authors: Jinghuan Gan
Zhichao Chen
Shuai Liu
Zhihong Shi
Yiming Liu
Xiao-Dan Wang
Chunyan Liu
Yong Ji
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Insomnia
Constipation
Mood Disorders
Hyperhidrosis
Dementia
Affective Disorder
Parkinson's Disease
Dementia
Constipation
Published in: BMC Neurology / Issue 1/2022
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-022-02897-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The presence and co-incidence of geriatric syndromes in older patients with mild-moderate Lewy body dementia

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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