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Open Access 01-12-2019 | Influenza Virus | Letter

Clinical significance of lymphocytopenia in patients hospitalized with pneumonia caused by influenza virus

Authors: Valeria Bellelli, Gabriella d’Ettorre, Luigi Celani, Cristian Borrazzo, Giancarlo Ceccarelli, Mario Venditti

Published in: Critical Care | Issue 1/2019

Excerpt

Recently, lymphocytopenia has been evaluated as an independent biomarker of mortality in hospitalized patients diagnosed with community-acquired pneumonia (CAP) [1, 2]. In these studies, patients recruited were affected by CAP due to different etiology, and no specific differences have been observed in viral and bacterial etiology distribution. On the other hand, in influenza virus infection, lymphocytopenia has been identified as a risk factor for bacterial superinfections [3], determining a worse prognosis. We would like to evaluate the potential role of lymphocytopenia as a prognostic factor in patients with pneumonia caused by influenza virus. …

Méndez R, Menéndez R, Amara-Elori I, Feced L, Piró A, Ramírez P, Sempere A, Ortega A, Bermejo-Martín JF, Torres A. Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality. J Inf Secur. 2019;78(6):423–31.

Bermejo-Martin JF, Cilloniz C, Mendez R, Almansa R, Gabarrus A, Ceccato A, Torres A, Menendez R, NEUMONAC group. Lymphopenic community acquired pneumonia (L-CAP), an immunological phenotype associated with higher risk of mortality. EBioMedicine. 2017;24:231–6.CrossRef

Zhou F, Li H, Gu L, Liu M, Xue C, Cao B, Wang C, for the National Influenza A(H1N1)pdm09 Clinical Investigation Group of China. Risk factors for nosocomial infection among hospitalised severe influenza A(H1N1)pdm09 patients. Respir Med. 2018;134:86–91.CrossRef

Giannella M, Rodríguez-Sánchez B, Roa PL, Catalán P, Muñoz P, García de Viedma D, Bouza E, Gregorio Marañón Task Force for Pneumonia GANG. Should lower respiratory tract secretions from intensive care patients be systematically screened for influenza virus during the influenza season? Crit Care. 2012;16(3):R104.CrossRef

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Title: Clinical significance of lymphocytopenia in patients hospitalized with pneumonia caused by influenza virus
Authors: Valeria Bellelli
Gabriella d’Ettorre
Luigi Celani
Cristian Borrazzo
Giancarlo Ceccarelli
Mario Venditti
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Influenza Virus
Lymphopenia
Community-Acquired Pneumonia
Pneumonia
Influenza Pneumonia
ECMO
ECMO
Published in: Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-019-2608-1

At a glance: The STEP trials

Springer Medicine

Clinical significance of lymphocytopenia in patients hospitalized with pneumonia caused by influenza virus

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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