Published in:
Open Access
01-12-2019 | Letter
Dosing adjuvant vitamin C in critically ill patients undergoing continuous renal replacement therapy: We are not there yet!
Authors:
Patrick M. Honore, David De Bels, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, Herbert D. Spapen
Published in:
Critical Care
|
Issue 1/2019
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Excerpt
We read with great interest the recent letter to
Critical Care by Marik and Hooper [
1]. Vitamin C (vit C) is increasingly recognized as a crucial compound to alleviate morbidity in critically ill patients. Vit C concentrations, however, are usually far below normal and even close to “scurvy levels” in this population. Vit C also is substantially cleared by continuous renal replacement therapy (CRRT). Significant vit C deficiency was observed in 80% of patients subjected to various types of CRRT despite receiving a daily intravenous (IV) supplement of 500 to 1000 mg [
2]. Therefore, high-dose (from 6 to 12 g) vit C substitution during CRRT seems justified [
3]. …
