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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 10/2006

01-10-2006 | Original Paper

Influence of Trypanosoma cruzi Chronic Infection in the Depletion of Esophageal Neurons in Calomys callosus

Authors: Leony Cristina Caetano, Sérgio Zucoloto, Laura Midori Kawasse, Miriam Paula AlonsoToldo, José Clóvis do Prado Jr.

Published in: Digestive Diseases and Sciences | Issue 10/2006

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Abstract

The extent of neuronal loss was studied in this work, in aged female Calomys callosus infected with the MORC-1 strain of Trypanosoma cruzi. Fifteen months after infection, one group of animals was immunosuppressed with cyclophosphamide (CY). Sections of the distal esophagus were collected and stained with cresyl violet. The neuron count was significantly different among groups, with enhanced neuronal loss in the infected group in comparison with the control aged noninfected group. Partial protection against neuronal destruction was observed in animals immunosuppressed with CY. The morphometry of the neuronal body displayed significant alterations concerning area, shape coefficient, and contour index that were statistically increased for the CY-infected group. These results indicate a protective role for CY against neuronal destruction.
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Metadata
Title
Influence of Trypanosoma cruzi Chronic Infection in the Depletion of Esophageal Neurons in Calomys callosus
Authors
Leony Cristina Caetano
Sérgio Zucoloto
Laura Midori Kawasse
Miriam Paula AlonsoToldo
José Clóvis do Prado Jr.
Publication date
01-10-2006
Published in
Digestive Diseases and Sciences / Issue 10/2006
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-006-9186-1

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