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Calcified Tissue International
Published in: Calcified Tissue International 4/2012

01-10-2012 | Original Research

Influence of Birth Weight on Calcaneal Bone Stiffness in Belgian Preadolescent Children

Authors: Karen Van den Bussche, Nathalie Michels, Luis Gracia-Marco, Diana Herrmann, Gabriele Eiben, Stefaan De Henauw, Isabelle Sioen

Published in: Calcified Tissue International | Issue 4/2012

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Abstract

The aim of this study was to investigate the relation between birth weight and calcaneal bone stiffness in a large sample of Belgian, healthy, preadolescent children. Participants were 827 children (3.6–11.2 years, 51.6 % boys) from the Belgian cohort of the IDEFICS study. Birth weight was obtained using a parental questionnaire, and quantitative ultrasound (QUS) measurements were performed to determine calcaneal broadband ultrasound attenuation (BUA), speed of sound (SOS), and stiffness index (SI) using the Lunar Achilles device. Average birth weights were 3435.7 ± 512.0 g for boys and 3256.9 ± 471.1 g for girls. Average calcaneal QUS measurements were 89.6 ± 24.0 (23.3–153.9) dB/MHz for BUA, 1621.4 ± 49.6 (1516.3–1776.5) m/s for SOS, and 92.8 ± 15.6 (49.0–163.0) for SI. Birth weight was positively associated with BUA (r = 0.13, p = 0.002) and SOS (r = –0.16, p < 0.001). The associations remained after correcting for age and sex in multiple regression analyses but disappeared after correcting for anthropometric covariates. Our findings suggest that birth weight, as a rough proxy indicator for genetic and environmental influences during intrauterine life, is associated with BUA and SOS in preadolescent children and may therefore influence the risk of osteoporosis later in life. Further studies using QUS are needed to investigate the consistency of the results of this study.
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Metadata
Title
Influence of Birth Weight on Calcaneal Bone Stiffness in Belgian Preadolescent Children
Authors
Karen Van den Bussche
Nathalie Michels
Luis Gracia-Marco
Diana Herrmann
Gabriele Eiben
Stefaan De Henauw
Isabelle Sioen
Publication date
01-10-2012
Publisher
Springer-Verlag
Published in
Calcified Tissue International / Issue 4/2012
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-012-9636-z

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