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01-12-2019 | Incisional Hernia | Original Article

Atraumatic laparoscopic intraperitoneal mesh fixation using a new laparoscopic device: an animal experimental study

Authors: R. N. Villalobos, M. C. Mias, C. Gas, Y. Maestre, M. Nogués, F. Vilardell, J. J. Olsina

Published in: Hernia | Issue 6/2019

Abstract

Purpose

Laparoscopic ventral and incisional hernia repair (LVIHR) has become a common procedure because of its feasibility and safety, but it is not free of complications. Acute and chronic post-operative pain and bleeding caused by traumatic fixation of the mesh are frequently prolonging the hospital stay. The aim of this study was to analyze the behavior of n-butyl-cyanoacrylate (GLUBRAN^® 2) as only mesh fixation

Methods

Ten female pigs were involved in the study and were divided into two groups of five (A and B). Animals in each group underwent a laparoscopic procedure in which two meshes were placed intraperitoneally and fixed with the same synthetic glue only. Animals in group A were sacrificed after 3 weeks, and those in group B were sacrificed after 12 weeks. We studied the morphological, biomechanical, and histological characteristics of the intraperitoneal mesh–tissue interface

Results

No disruption, migration or folding was observed in any of the pigs. In group A, the mean tensile strength was 1.4 N/cm (± 0.2) while in group B, the mean tensile strength was 2.5 N/cm (± 0.8). Histological analyses, in areas where mesh was fixed using the glue, showed a chronic lymphocytic inflammatory reaction with a granulomatous component and a marked desmoplastic reaction made up of immature collagen and numerous fibroblasts acquiring myofibroblastic characteristics. In some areas corresponding to fixation, the desmoplastic reaction originated from mature lamellar bone tissue with osteocytes and osteoblasts.

Conclusion

Laparoscopic mesh fixation with only the synthetic comonomer glue GLUBRAN^® 2 is feasible, effective, and safe in intraperitoneal incisional/ventral hernia repair in this animal model.

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Title: Atraumatic laparoscopic intraperitoneal mesh fixation using a new laparoscopic device: an animal experimental study
Authors: R. N. Villalobos
M. C. Mias
C. Gas
Y. Maestre
M. Nogués
F. Vilardell
J. J. Olsina
Publication date: 01-12-2019
Publisher: Springer Paris
Keyword: Incisional Hernia
Published in: Hernia / Issue 6/2019
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI: https://doi.org/10.1007/s10029-019-02008-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Atraumatic laparoscopic intraperitoneal mesh fixation using a new laparoscopic device: an animal experimental study

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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