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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-02-2019 | Short Communication

In vivo ¹⁹F MR inflammation imaging after myocardial infarction in a large animal model at 3 T

Authors: Maik Rothe, Annika Jahn, Kilian Weiss, Jong-Hee Hwang, Julia Szendroedi, Malte Kelm, Jürgen Schrader, Michael Roden, Ulrich Flögel, Florian Bönner

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2019

Abstract

Objectives

Fluorine-19 (¹⁹F) MRI with intravenously applied perfluorocarbons allows the in vivo monitoring of infiltrating immune cells as demonstrated in small animal models at high field. Here, we aimed to transfer this approach to a clinical scanner for detection of inflammatory processes in the heart after acute myocardial infarction (AMI) in a large animal model.

Materials and methods

Optimization of coil and sequence performance was carried out on phantoms and in vivo at a 3 T Philips Achieva. AMI was induced in Munich mini pigs by 90-min occlusion of the left anterior descending artery. At day 3 after AMI, pigs received a body weight-adjusted intravenous dose of a perfluorooctyl bromide nanoemulsion followed by ¹H/¹⁹F MRI at day 6 after AMI.

Results

A balanced steady-state free precession turbo gradient echo sequence using an ellipsoidal ¹⁹F/¹H surface coil provided the best signal-to-noise ratio and a superior localization of ¹⁹F patterns in vivo. This approach allowed the reliable detection of ¹⁹F signals in the injured myocardium within less than 20 min. The ¹⁹F signal magnitude correlated significantly with the functional impairment after AMI.

Conclusion

This study demonstrates the feasibility of in vivo ¹⁹F MR inflammation imaging after AMI at 3 T within a clinically acceptable acquisition time.

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Title: In vivo 19F MR inflammation imaging after myocardial infarction in a large animal model at 3 T
Authors: Maik Rothe
Annika Jahn
Kilian Weiss
Jong-Hee Hwang
Julia Szendroedi
Malte Kelm
Jürgen Schrader
Michael Roden
Ulrich Flögel
Florian Bönner
Publication date: 01-02-2019
Publisher: Springer International Publishing
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2019
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-018-0714-8

At a glance: The STEP trials

Springer Medicine

In vivo ¹⁹F MR inflammation imaging after myocardial infarction in a large animal model at 3 T

Abstract

Objectives

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

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