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Archives of Virology
Published in: Archives of Virology 6/2016

01-06-2016 | Original Article

In vitro antiviral effect of germacrone on feline calicivirus

Authors: Hongxia Wu, Yongxiang Liu, Shaopo Zu, Xue Sun, Chunguo Liu, Dafei Liu, Xiaozhan Zhang, Jin Tian, Liandong Qu

Published in: Archives of Virology | Issue 6/2016

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Abstract

Feline calicivirus (FCV) often causes respiratory tract and oral disease in cats and is a highly contagious virus. Widespread vaccination does not prevent the spread of FCV. Furthermore, the low fidelity of the RNA-dependent RNA polymerase of FCV leads to the emergence of new variants, some of which show increased virulence. Currently, few effective anti-FCV drugs are available. Here, we found that germacrone, one of the main constituents of volatile oil from rhizoma curcuma, was able to effectively reduce the growth of FCV strain F9 in vitro. This compound exhibited a strong anti-FCV effect mainly in the early phase of the viral life cycle. The antiviral effect depended on the concentration of the drug. In addition, germacrone treatment had a significant inhibitory effect against two other reference strains, 2280 and Bolin, and resulted in a significant reduction in the replication of strains WZ-1 and HRB-SS, which were recently isolated in China. This is the first report of antiviral effects of germacrone against a calicivirus, and extensive in vivo research is needed to evaluate this drug as an antiviral therapeutic agent for FCV.
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Metadata
Title
In vitro antiviral effect of germacrone on feline calicivirus
Authors
Hongxia Wu
Yongxiang Liu
Shaopo Zu
Xue Sun
Chunguo Liu
Dafei Liu
Xiaozhan Zhang
Jin Tian
Liandong Qu
Publication date
01-06-2016
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 6/2016
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-016-2825-8

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