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Immunity & Ageing
Published in: Immunity & Ageing 1/2013

Open Access 01-12-2013 | Research

Immunosenescence and gender: a study in healthy Cubans

Authors: Beatriz García Verdecia, Danay Saavedra Hernández, Patricia Lorenzo-Luaces, Teresita de Jesús Badía Alvarez, Idrissa Leonard Rupalé, Zaima Mazorra Herrera, Tania Crombet Ramos, Agustín Lage Dávila

Published in: Immunity & Ageing | Issue 1/2013

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Abstract

Background

The progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers.

Results

Different populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells.

Conclusion

Shifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. These patterns could have implications in the design of immunotherapy in the elderly.
Appendix
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Metadata
Title
Immunosenescence and gender: a study in healthy Cubans
Authors
Beatriz García Verdecia
Danay Saavedra Hernández
Patricia Lorenzo-Luaces
Teresita de Jesús Badía Alvarez
Idrissa Leonard Rupalé
Zaima Mazorra Herrera
Tania Crombet Ramos
Agustín Lage Dávila
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Immunity & Ageing / Issue 1/2013
Electronic ISSN: 1742-4933
DOI
https://doi.org/10.1186/1742-4933-10-16

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