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Immunity & Ageing
Published in: Immunity & Ageing 1/2012

Open Access 01-12-2012 | Research

Genetics of longevity. Data from the studies on Sicilian centenarians

Authors: Carmela R Balistreri, Giuseppina Candore, Giulia Accardi, Manuela Bova, Silvio Buffa, Matteo Bulati, Giusi I Forte, Florinda Listì, Adriana Martorana, Marisa Palmeri, Maria Valeria Pellicanò, Loredana Vaccarino, Letizia Scola, Domenico Lio, Giuseppina Colonna-Romano

Published in: Immunity & Ageing | Issue 1/2012

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Abstract

The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focused their attention on centenarians as optimal model to address the biological mechanisms of "successful and unsuccessful ageing". They are equipped to reach the extreme limits of human life span and, most importantly, to show relatively good health, being able to perform their routine daily life and to escape fatal age-related diseases, such as cardiovascular diseases and cancer. Thus, particular attention has been centered on their genetic background and immune system. In this review, we report our data gathered for over 10 years in Sicilian centenarians. Based on results obtained, we suggest longevity as the result of an optimal performance of immune system and an over-expression of anti-inflammatory sequence variants of immune/inflammatory genes. However, as well known, genetic, epigenetic, stochastic and environmental factors seem to have a crucial role in ageing and longevity. Epigenetics is associated with ageing, as demonstrated in many studies. In particular, ageing is associated with a global loss of methylation state. Thus, the aim of future studies will be to analyze the weight of epigenetic changes in ageing and longevity.
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Metadata
Title
Genetics of longevity. Data from the studies on Sicilian centenarians
Authors
Carmela R Balistreri
Giuseppina Candore
Giulia Accardi
Manuela Bova
Silvio Buffa
Matteo Bulati
Giusi I Forte
Florinda Listì
Adriana Martorana
Marisa Palmeri
Maria Valeria Pellicanò
Loredana Vaccarino
Letizia Scola
Domenico Lio
Giuseppina Colonna-Romano
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Immunity & Ageing / Issue 1/2012
Electronic ISSN: 1742-4933
DOI
https://doi.org/10.1186/1742-4933-9-8

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