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01-03-2017 | Review

Immunohistochemical detection of early myocardial infarction: a systematic review

Authors: Cristina Mondello, Luigi Cardia, Elvira Ventura-Spagnolo

Published in: International Journal of Legal Medicine | Issue 2/2017

Abstract

The postmortem diagnosis of early myocardial infarction is a challenge for forensic pathologists because the routine histology is neither specific. Many authors have suggested the use of the immunohistochemistry to fill the gaps in the histological diagnosis of early myocardial infarction. This review aims to analyse advances of immunohistochemical detection of early cardiac damage due to ischaemia. To this purpose, we reviewed experimental studies that investigated immunohistochemical markers and their estimated timing of expression. The review was performed according to specific inclusion and exclusion criteria, and a total of 23 studies assessing the immunohistochemical markers for the diagnosis and timing of early myocardial infarction were identified. The literature review highlights that the analysed markers are complement components, others being inflammatory mediators, cardiac cell proteins, plasma proteins, stress or hypoxia-induced factors and proteins associated with heart failure. All studies demonstrate the effectiveness of the tested markers in the early detection of myocardial infarction in both animal and human samples.

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Title: Immunohistochemical detection of early myocardial infarction: a systematic review
Authors: Cristina Mondello
Luigi Cardia
Elvira Ventura-Spagnolo
Publication date: 01-03-2017
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Legal Medicine / Issue 2/2017
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-016-1494-1

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Immunohistochemical detection of early myocardial infarction: a systematic review

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