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International Ophthalmology

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01-12-2024 | Idiopathic Intracranial Hypertension | Original Paper

Assessment of the relationship between structural and functional tests in patients with idiopathic intracranial hypertension

Authors: Kaveh Abri Aghdam, Mostafa Soltan Sanjari, Samira Chaibakhsh, Zahra Fathi, Pegah Kazemi, Ali Aghajani

Published in: International Ophthalmology | Issue 1/2024

Abstract

Purpose

To assess the relationship between structural and functional tests in mild and moderate idiopathic intracranial hypertension (IIH).

Methods

Patients with mild and moderate IIH and a control group were enrolled. Best-corrected visual acuity (BCVA), macular ganglion cell layer (MGCL) thickness, peripapillary retinal nerve fiber layer (pp RNFL) thickness, perimetric mean deviation (MD), and photopic negative responses (PhNR) of the electroretinogram were recorded. The associations between structural (pp RNFL and MGCL thickness) and functional (PhNR amplitude, MD and BCVA) parameters were assessed.

Results

154 eyes from 78 subjects (74 eyes from IIH patients and 80 eyes from healthy subjects) were included in this comparative observational study. The MGCL thickness, VA, pp RNFL, and PhNR base-to-trough (BT) amplitude were significantly worse in moderate IIH. The BCVA and MD were associated with MGCL thickness only in moderate IIH. The relationship between MD and MGCL thickness started when MD fell below −5.7 dB.

Conclusions

The association between functional and structural parameters varies between mild and moderate IIH. The MD and MGCL thickness outperformed in assessing disease severity in mild and moderate IIH, respectively. The association between MD and MGCL thickness could be considered in IIH severity categorization.

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Title: Assessment of the relationship between structural and functional tests in patients with idiopathic intracranial hypertension
Authors: Kaveh Abri Aghdam
Mostafa Soltan Sanjari
Samira Chaibakhsh
Zahra Fathi
Pegah Kazemi
Ali Aghajani
Publication date: 01-12-2024
Publisher: Springer Netherlands
Keyword: Idiopathic Intracranial Hypertension
Published in: International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-03054-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Assessment of the relationship between structural and functional tests in patients with idiopathic intracranial hypertension

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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