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Documenta Ophthalmologica

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01-02-2018 | Original Research Article

Electroretinography in idiopathic intracranial hypertension: comparison of the pattern ERG and the photopic negative response

Authors: Jason C. Park, Heather E. Moss, J. Jason McAnany

Published in: Documenta Ophthalmologica | Issue 1/2018

Abstract

Purpose

To evaluate the relationship between electrophysiological measures of retinal ganglion cell (RGC) function in patients who have idiopathic intracranial hypertension (IIH).

Methods

The pattern electroretinogram (pERG) and photopic negative response (PhNR) were recorded from 11 IIH patients and 11 age-similar controls. The pERG was elicited by a contrast-reversing checkerboard. The PhNR, a slow negative component following the flash ERG b-wave, was recorded in response to a long-wavelength flash presented against a short-wavelength adapting field. The PhNR was elicited using full-field (ffPhNR) and focal macular (fPhNR) stimuli. Additionally, Humphrey visual field mean deviation (HVF MD) was measured and ganglion cell complex volume (GCCV) was obtained by optical coherence tomography.

Results

The ffPhNR, fPhNR, and pERG amplitudes were outside of the normal range in 45, 9, and 45% of IIH patients, respectively. However, only mean ffPhNR amplitude was reduced significantly in the patients compared to controls (p < 0.01). The pERG amplitude correlated significantly with HVF MD and GCCV (both r > 0.65, p < 0.05). There were associations between ffPhNR amplitude and HVF MD (r = 0.58, p = 0.06) and with GCCV (r = 0.52, p = 0.10), but these did not reach statistical significance. fPhNR amplitude was not correlated significantly with HVF MD or GCCV (both r < 0.40, p > 0.20).

Conclusions

Although the fPhNR is generally normal in IIH, other electrophysiological measures of RGC function, the ffPhNR and pERG, are abnormal in some patients. These measures provide complementary information regarding RGC dysfunction in these individuals.

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Title: Electroretinography in idiopathic intracranial hypertension: comparison of the pattern ERG and the photopic negative response
Authors: Jason C. Park
Heather E. Moss
J. Jason McAnany
Publication date: 01-02-2018
Publisher: Springer Berlin Heidelberg
Published in: Documenta Ophthalmologica / Issue 1/2018
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-017-9620-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Electroretinography in idiopathic intracranial hypertension: comparison of the pattern ERG and the photopic negative response

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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