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International Ophthalmology

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01-12-2024 | Granulomatosis with Polyangiitis | Original Paper

Ocular manifestations of granulomatosis with polyangiitis: report from a tertiary eye care center

Authors: Ilayda Korkmaz, Ozlem Barut Selver, Sait Egrilmez, Ayse Yagci, Gokhan Keser, Kenan Aksu, Melis Palamar

Published in: International Ophthalmology | Issue 1/2024

Abstract

Purpose

To report demographic characteristics and ophthalmological manifestations of patients with granulomatosis with polyangiitis (GPA) in a tertiary eye care center in Turkey.

Methods

Medical records of patients with GPA-related ocular manifestations evaluated between 2013 and 2023 were included. Demographic and clinical characteristics of the patients including nature of systemic involvement, ophthalmologic symptoms and signs, laboratory investigations and treatment modality were reviewed.

Results

Twelve eyes of 10 patients (5 female/5 male) were included. The mean age was 57.2 ± 12.2 (35–71) years. Five (50%) patients were already diagnosed with GPA. Ocular involvement was the first manifestation of GPA in 3 patients. The remaining 2 patients had simultaneous systemic and ocular symptoms at presentation. Conjunctival hyperemia (9 eyes) and pain (7 eyes) were the most frequent presenting symptoms followed by blurred vision (3 eyes). The frequencies of ocular manifestations were as follows:episcleritis (3 eyes), isolated peripheral ulcerative keratitis (PUK) (3 eyes), scleritis (3 eyes), simultaneous PUK and scleritis (2 eyes) and periorbital mass (1 eye).

Conclusion

Ophthalmological manifestations can be the initial findings in GPA. Since GPA can affect different structures of the eye, it sometimes might be challenging for ophthalmologists. Therefore, it is crucial for ophthalmologists to be well-informed about GPA-related ocular findings and to have a high index of suspicion for GPA. Although PUK associated with scleritis is highly suggestive for GPA, isolated cases of PUK or scleritis can be seen in GPA. Therefore, it is important to adopt a multidisciplinary approach, consider GPA in differential diagnosis, and benefit from accurate diagnostic tests.

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Title: Ocular manifestations of granulomatosis with polyangiitis: report from a tertiary eye care center
Authors: Ilayda Korkmaz
Ozlem Barut Selver
Sait Egrilmez
Ayse Yagci
Gokhan Keser
Kenan Aksu
Melis Palamar
Publication date: 01-12-2024
Publisher: Springer Netherlands
Keywords: Granulomatosis with Polyangiitis
Granulomatosis with Polyangiitis
Published in: International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-02989-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Ocular manifestations of granulomatosis with polyangiitis: report from a tertiary eye care center

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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