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Open Access 01-12-2020 | Hypotension | Research article

Intraoperative hypotension is associated with shortened overall survival after lung cancer surgery

Authors: Wen-Wen Huang, Wen-Zhi Zhu, Dong-Liang Mu, Xin-Qiang Ji, Xue-Ying Li, Daqing Ma, Dong-Xin Wang

Published in: BMC Anesthesiology | Issue 1/2020

Abstract

Background

Intraoperative hypotension is associated with increased morbidity and mortality after surgery. We hypothesized that intraoperative hypotension might also be associated with worse long-term survival after cancer surgery. Herein, we analyzed the correlation between intraoperative hyper−/hypotension and overall survival after lung cancer surgery.

Methods

In this retrospective cohort study, 676 patients who received lung cancer surgery between January 1, 2006 and December 31, 2009 were reviewed. Intraoperative hyper- and hypotension were defined according to their correlation with long-term survival. The primary endpoint was overall survival. The association between episodes of intraoperative hyper−/hypotension and overall survival was analyzed with multivariable Cox proportional hazard models.

Results

Long-term follow-ups were completed in 515 patients with a median duration of 5.2 years. The estimated 5-year survival rates were 66.5, 61.3, 56.5, and 41.2% in patients with only hypertension (systolic blood pressure > 140 mmHg for ≥5 min), with both hyper- and hypotension (systolic blood pressure < 100 mmHg for ≥5 min), with neither hyper- nor hypotension, and with only hypotension during surgery, respectively. After adjusting confounding factors, intraoperative hypotension was significantly associated with shortened overall survival (compared with patients with only intraoperative hypertension, those with both hyper- and hypotension: hazard ratio [HR]1.033, 95% confidence interval [CI] 0.709 to 1.507, p = 0.864; those with neither hyper- nor hypotension: HR 0.952, 95% CI 0.608 to 1.489, p = 0.829; those with only hypotension: HR 1.736, 95% CI 1.218 to 2.475, p = 0.002).

Conclusions

For patients undergoing lung cancer surgery, intraoperative hypotension, but not hypertension, was associated with shortened overall survival.

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Title: Intraoperative hypotension is associated with shortened overall survival after lung cancer surgery
Authors: Wen-Wen Huang
Wen-Zhi Zhu
Dong-Liang Mu
Xin-Qiang Ji
Xue-Ying Li
Daqing Ma
Dong-Xin Wang
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Hypotension
Lung Cancer Surgery
Hypertension
Hypotension
Hypertension
Published in: BMC Anesthesiology / Issue 1/2020
Electronic ISSN: 1471-2253
DOI: https://doi.org/10.1186/s12871-020-01062-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intraoperative hypotension is associated with shortened overall survival after lung cancer surgery

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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