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01-07-2020 | Hypertension | Original Article

Energy-dependent effect trial of photobiomodulation on blood pressure in hypertensive rats

Authors: T. F. De Moraes, J. C. C. Filho, J. C. Oishi, L. Almeida-Lopes, N. A. Parizotto, G. J. Rodrigues

Published in: Lasers in Medical Science | Issue 5/2020

Abstract

The main purpose of this work was to construct an energy-dependent response curve of photobiomodulation on arterial pressure in hypertension animal model. To reach this objective, we have used a two-kidney one clip (2K-1C) rat model. Animals received acute laser light irradiation (660 nm) on abdominal region using different energy (0.6, 1.8, 3.6, 7.2, 13.8, 28.2, 55.8, and 111.6 J), the direct arterial pressure was measured by femoral cannulation, and systolic arterial pressure (SAP), diastolic arterial pressure (DAP), heart rate (HR), and time of effect were obtained. Our results indicated that 660 nm laser light presents an energy-dependent hypotensive effect, and 28.2 J energy irradiation reached the maximum hypotensive effect, inducing a decreased SAP, DAP, and HR (decrease in SAP: − 19.23 ± 1.82 mmHg, n = 11; DAP: − 9.57 ± 2.23 mmHg, n = 11; HR: − 39.15 ± 5.10 bpm, n = 11; and time of hypotensive effect: 3068.00 ± 719.00 s, n = 11). The higher energy irradiation evaluated (111.6 J) did not induce a hypotensive effect and induced an increase in HR (21.69 ± 7.89 bpm, n = 7). Taken together, our results indicate that red laser energy irradiation from 7.2 to 55.8 J is the effective therapeutic window to reduce SAP, DAP, MAP, and HR and induce a long-lasting hypotensive effect in rats, with effect loss at higher energy irradiation (111.6 J).

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Title: Energy-dependent effect trial of photobiomodulation on blood pressure in hypertensive rats
Authors: T. F. De Moraes
J. C. C. Filho
J. C. Oishi
L. Almeida-Lopes
N. A. Parizotto
G. J. Rodrigues
Publication date: 01-07-2020
Publisher: Springer London
Keywords: Hypertension
Laser
Hypertension
Published in: Lasers in Medical Science / Issue 5/2020
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-019-02883-5

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Energy-dependent effect trial of photobiomodulation on blood pressure in hypertensive rats

Abstract

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Springer Medicine

Abstract

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