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African Journal of Urology

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Open Access 01-12-2021 | Hypertension | Original Research

Presentation and management of pheochromocytomas and paragangliomas: about 40 cases

Authors: Faten Hadj kacem, Ameni Salah, Bilel Fathallah, Khouloud Boujelben, Nadia Charfi, Mohamed Abid

Published in: African Journal of Urology | Issue 1/2021

Abstract

Background

Pheochromocytoma and paraganglioma are rare neuroendocrine tumors of the chromaffin tissue, which may produce catecholamines. The aim of our study was to analyze the clinical and para-clinical aspects as well as the therapeutic and evolutionary aspects of pheocromocytomas and paragangliomas based on a series of 40 cases.

Methods

Our retrospective population-based research study includes 40 patients. Then, a statistical analysis was carried out using the SPSS software (version21).

Results

Our study involves 40 patients, including 23 women (57, 5%) and 17 men (42,5%). The mean age at the time of the diagnosis was 43.8 ± 16.8 years. The circumstances of the discovery were mainly characterized by adrenal incidentaloma and hypertension. The biological diagnosis was based on the dosage of urinary metanephrines and plasma-free metanephrines in, respectively, 61.5% and 18% of cases. A computerized tomography scan and/or a magnetic resonance imaging scan could help to locate the tumor in 100% of cases. Our series includes 3 cases of bilateral pheochromocytoma, 3 cases of paragangliomas and 1 case of malignant pheochromocytoma, while a hereditary form was retained in 3 patients. In fact, thirty-two patients were operated; cure was clinically labeled in 100% and biologically in 87.5% of patients.

Conclusions

The main points for improvement that our study has revealed are; a patient follow-up after surgery, which was not always regular, and an insufficient screening for genetic diseases associated with pheochromocytomas and paragangliomas.

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Title: Presentation and management of pheochromocytomas and paragangliomas: about 40 cases
Authors: Faten Hadj kacem
Ameni Salah
Bilel Fathallah
Khouloud Boujelben
Nadia Charfi
Mohamed Abid
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keywords: Hypertension
Hypertension
Neuroendocrine Tumor
Published in: African Journal of Urology / Issue 1/2021
Print ISSN: 1110-5704
Electronic ISSN: 1961-9987
DOI: https://doi.org/10.1186/s12301-021-00265-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Presentation and management of pheochromocytomas and paragangliomas: about 40 cases

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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