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Clinical Hypertension
Published in: Clinical Hypertension 1/2020

Open Access 01-12-2020 | Hypertension | Review

Metabolomics profiling in hypertension and blood pressure regulation: a review

Authors: John O. Onuh, Michel Aliani

Published in: Clinical Hypertension | Issue 1/2020

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Abstract

Hypertension is a chronic health condition in which blood pressure is usually elevated beyond normal levels. It can progress with serious complications if left undetected and untreated. Incidence of hypertension is on the increase worldwide with debilitating consequences on the health systems of many countries. It is a multifactorial disorder that requires a multi-pronged approach to address it. One such approach is the use of metabolomics or metabolite profiling to understand its underlying cause and possibly control it. Changes in metabolites profiles have been used to accurately predict so many disease conditions in addition to identifying possible biomarkers and pathways associated in their pathogenicity. This will enable their early detection, diagnosis and treatment as well as likely complications that may arise and also assist in development of biomarkers for clinical uses. The objective of this review therefore is to present some of the current knowledge on the application of metabolomics profiling in hypertension and blood pressure control.
Literature
1.
Ahhmed AM, Muguruma M. A review of meat protein hydrolysates and hypertension. Meat Sci. 2010;86(1):110–8.PubMedCrossRef
2.
Tan JL, Thakur K. Systolic hypertension. In: StatPearls. Treasure Island: StatPearls Publishing; 2019.
3.
Dietrich S, Floegel A, Weikert C, Prehn C, Adamski J, Pischon T, Boeing H, Drogan D. Identification of serum metabolites associated with incident hypertension in the European prospective investigation into cancer and Nutrition-Potsdam study. Hypertension. 2016;68(2):471–7.PubMedCrossRef
4.
Aluko RE. Food protein-derived renin-inhibitory peptides: in vitro and in vivo properties. J Food Biochem. 2019;43(1):e12648.PubMedCrossRef
5.
Erdmann K, Cheung BWY, Schroder H. The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. J Nutr Biochem. 2008;19(10):643–54.PubMedCrossRef
6.
7.
Akira K, Masu S, Imachi M, Mitome H, Hashimoto M, Hashimoto T. H-1 NMR-based metabonomic analysis of urine from young spontaneously hypertensive rats. J Pharmaceut Biomed. 2008;46(3):550–6.CrossRef
8.
Coutinho T, Bailey KR, Turner ST, Kullo IJ. Arterial stiffness is associated with increase in blood pressure over time in treated hypertensives. J Am Soc Hypertens. 2014;8(6):414–21.PubMedPubMedCentralCrossRef
9.
Danaei G, Lu Y, Singh GM, Carnahan E, Stevens GA, Cowan MJ, et al. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment. Lancet Diabetes Endocrinol. 2014;2:634–47.CrossRef
10.
Krakoff LR, Gillespie RL, Ferdinand KC, Fergus IV, Akinboboye O, Williams KA, Walsh MN, Bairey Merz CN, Pepine CJ. 2014 hypertension recommendations from the eighth joint national committee panel members raise concerns for elderly black and female populations. J Am Coll Cardiol. 2014;64(4):394–402.PubMedPubMedCentralCrossRef
11.
Lee SH, Qian ZJ, Kim SK. A novel angiotensin I converting enzyme inhibitory peptide from tuna frame protein hydrolysate and its antihypertensive effect in spontaneously hypertensive rats. Food Chem. 2010;118(1):96–102.CrossRef
12.
Navar-Boggan AM, Pencina MJ, Williams K, Sniderman AD, Peterson ED. Proportion of US adults potentially affected by the 2014 hypertension guideline. Jama. 2014;311(14):1424–9.PubMedCrossRef
13.
James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Lackland DT, LeFevre ML, MacKenzie TD, Ogedegbe O, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth Joint National Committee (JNC 8). Jama. 2014;311(5):507–20.PubMedCrossRef
14.
Hao Y, Wang Y, Xi L, Li G, Zhao F, Qi Y, Liu J, Zhao D. A nested case-control study of association between metabolome and hypertension risk. Biomed Res Int. 2016;2016:7646979.PubMedPubMedCentral
15.
Hu C, Kong H, Qu F, Li Y, Yu Z, Gao P, Peng S, Xu G. Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy. Mol BioSyst. 2011;7(12):3271–9.PubMedCrossRef
16.
Li Y, Nie L, Jiang H, Lin J, Zhou H, Xie J, Qu Z, Qi D, Zhang Y. Metabonomics study of essential hypertension and its chinese medicine subtypes by using gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy. Evid-Based Complement Alternat Med. 2013;2013:625906.PubMedPubMedCentral
17.
Zheng Y, Yu B, Alexander D, Mosley TH, Heiss G, Nettleton JA, Boerwinkle E. Metabolomics and incident hypertension among blacks: the atherosclerosis risk in communities study. Hypertension. 2013;62(2):398–403.PubMedCrossRef
18.
19.
Vermeirssen V, Van Camp J, Verstraete W. Bioavailability of angiotensin I converting enzyme inhibitory peptides. Br J Nutr. 2004;92(3):357–66.CrossRefPubMed
20.
Aa JY, Wang GJ, Hao HP, Huang Q, Lu YH, Yan B, Zha WB, Liu LS, Kang A. Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats. Acta Pharmacol Sin. 2010;31(8):930–7.PubMedPubMedCentralCrossRef
21.
Brindle JT, Nicholson JK, Schofield PM, Grainger DJ, Holmes E. Application of chemometrics to 1H NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension. Analyst. 2003;128(1):32–6.PubMedCrossRef
22.
Lu Y, Jiye A, Wang G, Hao H, Huang Q, Yan B, Zha W, Gu S, Ren H, Zhang Y, et al. Gas chromatography/time-of-flight mass spectrometry based metabonomic approach to differentiation hypertension- and age-related metabolic variation in spontaneously hypertensive rats. Rapid Commun Mass Sp. 2008;22:7.
23.
Akira K, Masu S, Imachi M, Mitome H, Hashimoto T. A metabonomic study of biochemical changes characteristic of genetically hypertensive rats based on H-1 NMR spectroscopic urinalysis. Hypertens Res. 2012;35(4):404–12.PubMedCrossRef
24.
Akira K, Hichiya H, Morita M, Shimizu A, Mitome H. Metabonomic study on the biochemical response of spontaneously hypertensive rats to chronic taurine supplementation using H-1 NMR spectroscopic urinalysis. J Pharmaceut Biomed. 2013;85:155–61.CrossRef
25.
Bruce SJ, Tavazzi I, Parisod V, Rezzi S, Kochhar S, Guy PA. Investigation of human blood plasma sample preparation for performing metabolomics using ultrahigh performance liquid chromatography/mass spectrometry. Anal Chem. 2009;81(9):3285–96.PubMedCrossRef
26.
Onuh JO, Girgih AT, Nwachukwu I, Ievari-Shariati S, Raj P, Netticadan T, Aluko RE, Aliani M. A metabolomics approach for investigating urinary and plasma changes in spontaneously hypertensive rats (SHR) fed with chicken skin protein hydrolysates diets. J Funct Foods. 2016;22:20–33.CrossRef
27.
Onuh JO, Aluko RE. Metabolomics as a tool to study the mechanism of action of bioactive protein hydrolysates and peptides. Trends Food Sci Tech. 2019;91:9.CrossRef
28.
Law WS, Huang PY, Ong ES, Ong CN, Li SFY, Pasikanti KK, Chan ECY. Metabonomics investigation of human urine after ingestion of green tea with gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry and H-1 NMR spectroscopy. Rapid Commun Mass Sp. 2008;22(16):2436–46.CrossRef
29.
Wishart DS. Metabolomics: applications to food science and nutrition research. Trends Food Sci Tech. 2008;19(9):482–93.CrossRef
30.
Llorach R, Urpi-Sarda M, Jauregui O, Monagas M, Andres-Lacueva C. An LC-MS-based metabolomics approach for exploring urinary metabolome modifications after cocoa consumption. J Proteome Res. 2009;8(11):5060–8.PubMedCrossRef
31.
Hanifa MA, Skott M, Maltesen RG, Rasmussen BS, Nielsen S, Frokiaer J, Ring T, Wimmer R. Tissue, urine and blood metabolite signatures of chronic kidney disease in the 5/6 nephrectomy rat model. Metabolomics. 2019;15(8):112.PubMedCrossRef
32.
Zhang ZH, Chen H, Vaziri ND, Mao JR, Zhang L, Bai X, Zhao YY. Metabolomic signatures of chronic kidney disease of diverse etiologies in the rats and humans. J Proteome Res. 2016;15(10):3802–12.PubMedCrossRef
33.
James EL, Parkinson EK. Serum metabolomics in animal models and human disease. Curr Opin Clin Nutr Metab Care. 2015;18(5):478–83.PubMedCrossRef
34.
Jiye A, Huang Q, Wang G, Zha W, Yan B, Ren H, Gu S, Zhang Y, Zhang Q, Shao F, et al. Global analysis of metabolites in rat and human urine based on gas chromatography/time-of-flight mass spectrometry. Anal Biochem. 2008;379(1):20–6.PubMedCrossRef
35.
Lin YT, Salihovic S, Fall T, Hammar U, Ingelsson E, Arnlov J, Lind L, Sundstrom J. Global plasma metabolomics to identify potential biomarkers of blood pressure progression. Arterioscler Thromb Vasc Biol. 2020;40(8):e227–37.PubMedCrossRef
36.
van Deventer CA, Lindeque JZ, van Rensburg PJJ, Malan L, van der Westhuizen FH, Louw R. Use of metabolomics to elucidate the metabolic perturbation associated with hypertension in a black south African male cohort: the SABPA study. J Am Soc Hypertens. 2015;92(2):104–14.CrossRef
37.
Zhong L, Zhang JP, Nuermaimaiti AG, Yunusi KX. Study on plasmatic metabolomics of Uygur patients with essential hypertension based on nuclear magnetic resonance technique. Eur Rev Med Pharmacol Sci. 2014;18(23):3673–80.PubMed
38.
Mellen PB, Bleyer AJ, Erlinger TP, Evans GW, Nieto FJ, Wagenknecht LE, Wofford MR, Herrington DM. Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study. Hypertension. 2006;48(6):1037–42.PubMedCrossRef
39.
Kulkarni H, Meikle PJ, Mamtani M, Weir JM, Barlow CK, Jowett JB, Bellis C, Dyer TD, Johnson MP, Rainwater DL, et al. Plasma lipidomic profile signature of hypertension in Mexican American families: specific role of diacylglycerols. Hypertension. 2013;62(3):621–6.PubMedCrossRef
40.
Nikolic SB, Sharman JE, Adams MJ, Edwards LM. Metabolomics in hypertension. J Hypertens. 2014;32(6):1159–69.PubMedCrossRef
Metadata
Title
Metabolomics profiling in hypertension and blood pressure regulation: a review
Authors
John O. Onuh
Michel Aliani
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Clinical Hypertension / Issue 1/2020
Electronic ISSN: 2056-5909
DOI
https://doi.org/10.1186/s40885-020-00157-9

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