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Current Nutrition Reports

Management of Cardiovascular Diseases by Short-Chain Fatty Acid Postbiotics

Published in:
Authors
Seyed Sadeq Mousavi Ghahfarrokhi
Mohamadsadegh Mohamadzadeh
Nasrin Samadi
Mohammad Reza Fazeli
Sara Khaki
Bahman Khameneh
Ramin Khameneh Bagheri
Published in
Current Nutrition Reports | Issue 2/2024

Abstract

Purpose of Review

Global health concerns persist in the realm of cardiovascular diseases (CVDs), necessitating innovative strategies for both prevention and treatment. This narrative review aims to explore the potential of short-chain fatty acids (SCFAs)—namely, acetate, propionate, and butyrate—as agents in the realm of postbiotics for the management of CVDs.

Recent Findings

We commence our discussion by elucidating the concept of postbiotics and their pivotal significance in mitigating various aspects of cardiovascular diseases. This review centers on a comprehensive examination of diverse SCFAs and their associated receptors, notably GPR41, GPR43, and GPR109a. In addition, we delve into the intricate cellular and pharmacological mechanisms through which these receptors operate, providing insights into their specific roles in managing cardiovascular conditions such as hypertension, atherosclerosis, heart failure, and stroke.

Summary

The integration of current information in our analysis highlights the potential of both SCFAs and their receptors as a promising path for innovative therapeutic approaches in the field of cardiovascular health. The idea of postbiotics arises as an optimistic and inventive method, presenting new opportunities for preventing and treating cardiovascular diseases.
Title
Management of Cardiovascular Diseases by Short-Chain Fatty Acid Postbiotics
Authors
Seyed Sadeq Mousavi Ghahfarrokhi
Mohamadsadegh Mohamadzadeh
Nasrin Samadi
Mohammad Reza Fazeli
Sara Khaki
Bahman Khameneh
Ramin Khameneh Bagheri
Publication date
24-04-2024
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 2/2024
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-024-00531-1
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