Published in:
02-04-2024 | Hypertension | COMMENT
CPAP Treatment in Resistant Hypertension
Authors:
Grace Oscullo, Jose Daniel Gomez-Olivas, Miguel Ángel Martínez-García
Published in:
Current Sleep Medicine Reports
|
Issue 2/2024
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Excerpt
Broadly speaking, it can be stated that approximately half the patients with arterial hypertension (AHT) present obstructive sleep apnea (OSA) and that half of the individuals with OSA present AHT [
1]. Although both diseases are enormously prevalent in the world population and therefore can appear synchronously in many cases [
2,
3], there is sufficient biological plausibility to suggest that the presence of OSA is capable of generating high blood pressure levels or making them difficult to control [
1,
4]. Intermittent hypoxaemia (IH), generated by respiratory events during sleep, seems to be the factor that produces the greatest impact on the pathophysiological pathways responsible for increasing blood pressure levels and the incidence of cardiovascular events [
5‐
10]. With regard to AHT, sympathetic hyperactivity and, to a lesser extent, activation of the renin–angiotensin–aldosterone (RAA) axis produced by IH itself, seem to be the main pathways that explain this association [
1,
6,
11,
12]. …
