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Open Access 01-12-2021 | Hypertension | Research

A case-control study of Dietary Approaches to Stop Hypertension (DASH) diets, colorectal cancer and adenomas among Iranian population

Authors: Saeede Jafari Nasab, Matin Ghanavati, Pegah Rafiee, Alireza Bahrami, Nazanin Majidi, Cain C. T. Clark, Amir Sadeghi, Mohammad Houshyari, Ehsan Hejazi

Published in: BMC Cancer | Issue 1/2021

Abstract

Background and aims

Colorectal cancer (CRC) is the third most common cancer, worldwide. Recently, much attention has been given to the association between Dietary Approaches to Stop Hypertension (DASH) and CRC, however, data on colorectal adenomas (CRAs) as its precursor are scarce. Thus, the purpose of this case-control study was to investigate the association of DASH score with the risk of CRC and CRA in Iranian adults.

Method

A total of 499 participants, including 129 CRC and 130 CRA cases, along with 240 controls, were asked about their dietary intake via a validated questionnaire. The DASH score was then calculated based on a priori methods and categorized in quartiles. Multivariate logistic regression was performed to assess the association of DASH score and the risk of CRC and CRA.

Results

After adjusting for confounding variables, adherence to the DASH diet was associated with a reduction in the risk of CRC and CRA, respectively (OR of 4th versus 1st quartile = 0.04, 95% CI: 0.01–0.11, OR = 0.10, 95% CI: 0.04–0.22). Also, subgroup analysis based on gender showed that women and men with a higher DASH score had a significantly lower risk of CRC and CRAs.

Conclusion

The results of this study demonstrated that adherence to a DASH dietary pattern could reduce the risk of CRC and CRA in men and women. Promoting a DASH eating plan can be helpful in reducing the risk of CRC.

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Title: A case-control study of Dietary Approaches to Stop Hypertension (DASH) diets, colorectal cancer and adenomas among Iranian population
Authors: Saeede Jafari Nasab
Matin Ghanavati
Pegah Rafiee
Alireza Bahrami
Nazanin Majidi
Cain C. T. Clark
Amir Sadeghi
Mohammad Houshyari
Ehsan Hejazi
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Hypertension
Colorectal Cancer
Colorectal Cancer
Hypertension
Published in: BMC Cancer / Issue 1/2021
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-021-08786-5

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