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Open Access 01-12-2015 | Research article

Increased colorectal cancer incidence in Iran: a systematic review and meta-analysis

Authors: Roya Dolatkhah, Mohammad Hossein Somi, Iraj Asvadi Kermani, Morteza Ghojazadeh, Mohamad Asghari Jafarabadi, Faris Farassati, Saeed Dastgiri

Published in: BMC Public Health | Issue 1/2015

Abstract

Background

Colorectal cancer is the third most common cancer in Iran. The increasing trend of colorectal cancer incidence in Iran and the close relationship with the geographical location are the underlying reasons for this study.

Methods

Data source: Eleven databases, including MEDLINE, EMBASE, SCOPUS, and four other databases, for articles in Persian were searched from April 2014 to October 2014. Additional data were obtained from an online survey of the Central Library of Tabriz Faculty of Medicine. Study eligibility criteria: In this systematic review and meta-analysis, we included studies reporting different measures of incidence, age-standardized incidence rates, and crude incidence rates. All rates (per 100,000 person-years) were standardized to the world standard population. Study appraisal and synthesis methods: A preliminary review of the title and abstracts of these articles was used to exclude any that were clearly irrelevant. The full text review determined whether the article was relevant to our topic. All the potentially relevant manuscripts were reviewed by two other investigators (S.D., M.G.). A total of 39 studies (10 Persian and 29 English articles) from different provinces and diverse areas of Iran, were analyzed in this study using comprehensive meta-analysis software. For accuracy studies, we used estimated rates for males and females with 95 % confidence intervals.

Results

Age-standardized incidence rates were obtained based on the random effects model and were 8.16 (95 % CI: 6.64 to 9.68) and 6.17 (95 % CI: 5.01 to 7.32) for males and females, respectively. The random crude rates were 5.58 (95 % CI: 4.22 to 6.94) for males and 4.01 (95 % CI: 3.06 to 4.97) for females.

Conclusions

Colorectal cancer incidence rates rise due to individual and environmental risk factors as well as improvement in the registry system and increase in access to health services. A more executed organized and structured system for collecting cancer data, in all cities and rural areas of the country, is an essential priority.

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Title: Increased colorectal cancer incidence in Iran: a systematic review and meta-analysis
Authors: Roya Dolatkhah
Mohammad Hossein Somi
Iraj Asvadi Kermani
Morteza Ghojazadeh
Mohamad Asghari Jafarabadi
Faris Farassati
Saeed Dastgiri
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Public Health / Issue 1/2015
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/s12889-015-2342-9

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Increased colorectal cancer incidence in Iran: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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