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European Journal of Nutrition
Published in: European Journal of Nutrition 1/2022

01-02-2022 | Hypertension | Original Contribution

Blueberry extract improves redox balance and functional parameters in the right ventricle from rats with pulmonary arterial hypertension

Authors: Patrick Türck, Isadora Schein Salvador, Cristina Campos-Carraro, Vanessa Ortiz, Alan Bahr, Michael Andrades, Adriane Belló-Klein, Alex Sander da Rosa Araujo

Published in: European Journal of Nutrition | Issue 1/2022

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Abstract

Purpose

Pulmonary arterial hypertension (PAH) is a disease characterized by increased pulmonary vascular resistance and right ventricle (RV) failure. In this context, oxidative stress is an essential element contributing to PAH’s pathophysiology. Thus, blueberry (BB), which has a high antioxidant capacity, emerges as a natural therapeutic approach in PAH. This work evaluated the effect of BB extract on redox balance in RV in a PAH’s animal model.

Methods

Male Wistar rats (200 ± 20 g) (n = 72) were randomized into eight groups: control (CTR); monocrotaline (MCT); CTR and MCT treated at doses of 50, 100, and 200 mg/kg BB. PAH was induced by administration of MCT (60 mg/kg, intraperitoneal). Rats were treated with BB orally for 5 weeks (2 weeks before monocrotaline and 3 weeks after monocrotaline injection). On day 35, rats were submitted to echocardiography and catheterization, then euthanasia and RV harvesting for biochemical analyses.

Results

RV hypertrophy, observed in the MCT groups, was reduced with BB treatment. MCT elevated RV systolic pressure and pressure/time derivatives, while the intervention with BB decreased these parameters. PAH decreased RV output and pulmonary artery outflow acceleration/ejection time ratio, while increased RV diameters, parameters restored by BB treatment. Animals from the MCT group showed elevated lipid peroxidation and NADPH oxidase activity, outcomes attenuated in animals treated with BB, which also led to increased catalase activity.

Conclusion

Treatment with BB partially mitigated PAH, which could be associated with improvement of RV redox state. Such findings constitute an advance in the investigation of the role of BB extract in chronic progressive cardiovascular diseases that involve the redox balance, such as PAH.
Appendix
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Literature
1.
Humbert M, Guignabert C, Bonnet S, Dorfmüller P, Klinger JR, Nicolls MR, Olschewski AJ, Pullamsetti SS, Schermuly RT, Stenmark KR, Rabinovitch M (2019) Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives. Eur Respir J 53:1801887PubMedPubMedCentralCrossRef
2.
Vonk Noordegraaf A, Chin KM, Haddad F, Hassoun PM, Hemnes AR, Hopkins SR, Kawut SM, Langleben D, Lumens J, Naeije R (2019) Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update. Eur Respir J 53:1801900PubMedPubMedCentralCrossRef
3.
Demarco VG, Whaley-Connell AT, Sowers JR, Habibi J, Dellsperger KC (2010) Contribution of oxidative stress to pulmonary arterial hypertension. World J Cardiol 2:316–324PubMedPubMedCentralCrossRef
4.
Dos Santos LD, Türck P, de Lima-Seolin BG, Colombo R, Ortiz VD, Bonetto JHP, Campos-Carraro C, Bianchi SE, Belló-Klein A, Bassani VL, Araujo ASR (2017) Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model. Br J Pharmacol 174:3302–3314CrossRef
5.
6.
Mikhael M, Makar C, Wissa A, Le T, Eghbali M, Umar S (2019) Oxidative stress and its implications in the right ventricular remodeling secondary to pulmonary hypertension. Front Physiol 10:1233PubMedPubMedCentralCrossRef
7.
Yet SF, Perrella MA, Layne MD, Hsieh CM, Maemura K, Kobzik L, Wiesel P, Christou H, Kourembanas S, Lee ME (1999) Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Investig 103:R23–R29PubMedPubMedCentralCrossRef
8.
Chaumais MC, Ranchoux B, Montani D, Dorfmüller P, Tu L, Lecerf F, Raymond N, Guignabert C, Price L, Simonneau G, Cohen-Kaminsky S, Humbert M, Perros F (2014) N-acetylcysteine improves established monocrotaline-induced pulmonary hypertension in rats. Respir Res 15:65PubMedPubMedCentralCrossRef
9.
Türck P, Lacerda DS, Carraro CC, de Lima-Seolin BG, Teixeira RB, Bonetto JHP, Colombo R, Schenkel PC, Belló-Klein A, da Rosa Araujo AS (2018) Trapidil improves hemodynamic, echocardiographic and redox state parameters of right ventricle in monocrotaline-induced pulmonary arterial hypertension model. Biomed Pharmacothererapy 103:182–190CrossRef
10.
Zimmer A, Teixeira RB, Bonetto JHP, Bahr AC, Türck P, de Castro AL, Campos-Carraro C, Visioli F, Fernandes-Piedras TR, Casali KR, Scassola CMC, Baldo G, Araujo AS, Singal P, Belló-Klein A (2020) Role of inflammation, oxidative stress, and autonomic nervous system activation during the development of right and left cardiac remodeling in experimental pulmonary arterial hypertension. Mol Cell Biochem 464:93–109PubMedCrossRef
11.
Reis GS, Augusto VS, Silveira AP, Jordão AA Jr, Baddini-Martinez J, Poli Neto O, Rodrigues AJ, Evora PR (2013) Oxidative-stress biomarkers in patients with pulmonary hypertension. Pulmonary Circulation 3(4):856–861PubMedPubMedCentralCrossRef
12.
Ghasemzadeh N, Patel RS, Eapen DJ, Veledar EA, Kassem H, Manocha P, Khayata M, Zafari AM, Sperling L, Jones DP, Quyyumi AA (2014) Oxidative stress is associated with increased pulmonary artery systolic pressure in humans. Hypertension 63:1270–1275PubMedCrossRef
13.
Sitbon O, Gomberg-Maitland M, Granton J, Lewis MI, Mathai SC, Rainisio M, Stockbridge NL, Wilkins MR, Zamanian RT, Rubin LJ (2019) Clinical trial design and new therapies for pulmonary arterial hypertension. Eur Respir J 53:1801908PubMedPubMedCentralCrossRef
14.
Frei B (1994) Natural Antioxidants in Human Health and Disease, 1st edn. Academic Press, Boston, Massachusetts
15.
Belló-Klein A, Khaper N, Llesuy S, Vassallo DV, Pantos C (2014) Oxidative stress and antioxidant strategies in cardiovascular disease. Oxidative Med Cellular Longevity 2014:678741CrossRef
16.
17.
Jain AK, Mehra NK, Swarnakar NK (2015) Role of antioxidants for the treatment of cardiovascular diseases: challenges and opportunities. Curr Pharm Des 21:4441–4455PubMedCrossRef
18.
Basu A, Rhone M, Lyons TJ (2010) Berries: emerging impact on cardiovascular health. Nutr Rev 68:168–177PubMedCrossRef
19.
Louis XL, Thandapilly SJ, Kalt W, Vinqvist-Tymchuk M, Aloud BM, Raj P, Yu L, Le H, Netticadan T (2014) Blueberry polyphenols prevent cardiomyocyte death by preventing calpain activation and oxidative stress. Food Funct 5:1785–1794PubMedCrossRef
20.
Song Y, Huang L, Yu J (2016) Effects of blueberry anthocyanins on retinal oxidative stress and inflammation in diabetes through Nrf2/HO-1 signaling. J Neuroimmunol 301:1–6PubMedCrossRef
21.
Eladwy RA, Mantawy EM, El-Bakly WM, Fares M, Ramadan LA, Azab SS (2018) Mechanistic insights to the cardioprotective effect of blueberry nutraceutical extract in isoprenaline-induced cardiac hypertrophy. Phytomedicine 51:84–93PubMedCrossRef
22.
Liu Y, Tan D, Shi L, Liu X, Zhang Y, Tong C, Song D, Hou M (2015) Blueberry anthocyanins-enriched extracts attenuate cyclophosphamide-induced cardiac injury. PLoS ONE 10:e0127813PubMedPubMedCentralCrossRef
23.
Ahmet I, Spangler E, Shukitt-Hale B, Juhaszova M, Sollott SJ, Joseph JA, Ingram DK, Talan M (2009) Blueberry-enriched diet protects rat heart from ischemic damage. PLoS ONE 4:e5954PubMedPubMedCentralCrossRef
24.
Ahmet I, Spangler E, Shukitt-Hale B, Joseph JA, Ingram DK, Talan M (2009) Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats. PLoS ONE 4:e7975PubMedPubMedCentralCrossRef
25.
Türck P, Fraga S, Salvador I, Campos-Carraro C, Lacerda D, Bahr A, Ortiz V, Hickmann A, Koetz M, Belló-Klein A, Henriques A, Agostini F, da Rosa Araujo AS (2020) Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension. Nutrition 70:110579PubMedCrossRef
26.
Yin FC, Spurgeon HA, Rakusan K, Weisfeldt ML, Lakatta EG (1982) Use of tibial length to quantify cardiac hypertrophy: application in the aging rat. Am J Physiol 243:H941–H947PubMed
27.
Augustine DX, Coates-Bradshaw LD, Willis J, Harkness A, Ring L, Grapsa J, Coghlan G, Kaye N, Oxborough D, Robinson S, Sandoval J, Rana BS, Siva A, Nihoyannopoulos P, Howard LS, Fox K, Bhattacharyya S, Sharma V, Steeds RP, Mathew T (2018) Echocardiographic assessment of pulmonary hypertension: a guideline protocol from the British Society of Echocardiography. Echo Res Practice 5:G11–G24CrossRef
28.
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275PubMedCrossRef
29.
Lebel CP, Ischiropoulos H, Bondy SC (1992) Evaluation of the Probe 2’,7’-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5:227–231PubMedCrossRef
30.
Llesuy SF, Milei J, Gonzalez Flecha BS, Boveris A (1990) Myocardial damage induced by doxorubicins: hydroperoxide-initiated chemiluminescence and morphology. Free Radical Biol Med 8:259–264CrossRef
31.
Wei Y, Sowers JR, Nistala R, Gong H, Uptergrove GM, Clark SE, Morris EM, Szary N, Manrique C, Stump CS (2006) Angiotensin II-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells. J Biol Chem 281:35137–35146PubMedCrossRef
32.
Boveris A, Chance B (1973) The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochemical Journal 134:707–716PubMedCentralCrossRef
33.
Marklund SL (1985) Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB/c mice. Mutat Res 148:129–134PubMedCrossRef
34.
Mills GC (1957) Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown. J Biol Chem 229:189–197PubMedCrossRef
35.
Aksenov MY, Markesbery WR (2001) Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer’s disease. Neurosci Lett 302:141–145PubMedCrossRef
36.
Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680–685PubMedCrossRef
37.
Klein D, Kern RM, Sokol RZ (1995) A method for quantification and correction of proteins after transfer to immobilization membranes. Biochem Mol Biol Int 36:59–66PubMed
38.
Galiè N, Humbert M, Vachiery J, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Sanchez MAG, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M (2015) 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J 46:903–975PubMedCrossRef
39.
Nair AR, Mariappan N, Stull AJ, Francis J (2017) Blueberry supplementation attenuates oxidative stress within monocytes and modulates immune cell levels in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Food Funct 8:4118–4128PubMedCrossRef
40.
Sun Y, Nemec-Bakk AS, Mallik AU, Bagchi AK, Singal PK, Khaper N (2019) Blueberry extract attenuates doxorubicin-induced damage in H9c2 cardiac cells. Can J Physiol Pharmacol 97:880–884PubMedCrossRef
41.
Von Siebenthal C, Aubert JD, Mitsakis P, Yerly P, Prior JO, Nicod LP (2016) Pulmonary hypertension and indicators of right ventricular function. Front Med (Lausanne) 3:23
42.
Ryan JJ, Huston J, Kutty S, Hatton ND, Bowman L, Tian L, Herr JE, Johri AM, Archer SL (2015) Right ventricular adaptation and failure in pulmonary arterial hypertension. Can J Cardiol 31:391–406PubMedCrossRef
43.
Lima-Seolin BG, Colombo R, Bonetto JHP, Teixeira RB, Donatti LM, Casali KR, Godoy AEG, Litvin IE, Schenkel PC, Araujo ASR, Belló-Klein A (2017) Bucindolol improves right ventricle function in rats with pulmonary arterial hypertension through the reversal of autonomic imbalance. Eur J Pharmacol 798:57–65PubMedCrossRef
44.
Campos-Carraro C, Türck P, de Lima-Seolin BG, Tavares AMV, Dos Santos LD, Corssac GB, Teixeira RB, Hickmann A, Llesuy S, da Rosa Araujo AS, Belló-Klein A (2018) Copaiba oil attenuates right ventricular remodeling by decreasing myocardial apoptotic signaling in monocrotaline-induced rats. J Cardiovasc Pharmacol 72:214–221PubMedCrossRef
45.
Huang Z, Liu Z, Luo Q, Zhao Z, Zhao Q, Zheng Y, Xi Q, Tang Y (2016) Glycoprotein 130 inhibitor ameliorates monocrotaline-induced pulmonary hypertension in rats. Can J Cardiol 32:1356.e1-1356.e10CrossRef
46.
Jasińska-Stroschein M, Owczarek J, Sołtysiak U, Orszulak-Michalak D (2016) Rosuvastatin intensifies the beneficial effects of rho-kinase inhibitor in reversal of monocrotaline-induced pulmonary hypertension. Arch Med Sci 2:898–905CrossRef
47.
Harrison A, Hatton N, Ryan JJ (2015) The right ventricle under pressure: evaluating the adaptive and maladaptive changes in the right ventricle in pulmonary arterial hypertension using echocardiography (2013 Grover Conference series). Pulmonary Cir 5:29–47CrossRef
48.
Falcão-Pires I, Gonçalves N, Henriques-Coelho T, Moreira-Gonçalves D, Roncon-Albuquerque R Jr, Leite-Moreira AF (2006) Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension. Am J Physiol-Heart and Cir Physiol 296:H2007–H2014CrossRef
49.
Vonk Noordegraaf A, Galiè N (2011) The role of the right ventricle in pulmonary arterial hypertension. Eur Respir Rev 20:243–253PubMedCrossRef
50.
Howard LS, Grapsa J, Dawson D, Bellamy M, Chambers JB, Masani ND, Nihoyannopoulos P, Gibbs JSR (2012) Echocardiographic assessment of pulmonary hypertension: standard operating procedure. Eur Respir Rev 21:239–248PubMedCrossRef
51.
Pasierski TJ, Starling RC, Binkley PF, Pearson AC (1999) Echocardiographic evaluation of pulmonary artery distensibility. Chest 103:1080–1083CrossRef
52.
Naeije R, Manes A (2014) The right ventricle in pulmonary arterial hypertension. Eur Respir Rev 23:476–487PubMedCrossRef
53.
Baybutt RC, Molteni A (1999) Dietary beta-carotene protects lung and liver parenchyma of rats treated with monocrotaline. Toxicology 137:69–80PubMedCrossRef
54.
Baybutt RC, Herndon BL, Umbehr J, Mein J, Xue Y, Reppert S, Van Dillen C, Kamal R, Halder A, Molteni A (2007) Effects on cytokines and histology by treatment with the ACE inhibitor captopril and the antioxidant retinoic acid in the monocrotaline model of experimentally induced lung fibrosis. Curr Pharm Des 13:1327–1333PubMedCrossRef
55.
Skrovankova S, Sumczynski D, Mlcek J, Jurikova T, Sochor J (2015) Bioactive compounds and antioxidant activity in different types of berries. Int J Mol Sci 16:24673–24706PubMedPubMedCentralCrossRef
56.
Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P (2018) Oxidative stress, aging, and diseases. Clin Interv Aging 13:757–772PubMedPubMedCentralCrossRef
57.
Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, Mann GE, Moore K, Roberts LJ 2nd, Ischiropoulos H (2012) Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radical Biol Med 52:1–6CrossRef
58.
Veit F, Pak O, Egemnazarov B, Roth M, Kosanovic D, Seimetz M, Sommer N, Ghofrani HA, Seeger W, Grimminger F, Brandes RP, Schermuly RT, Weissmann N (2013) Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling. Antioxid Redox Signal 19:2213–2231PubMedCrossRef
59.
Huetsch JC, Suresh K, Shimoda LA (2019) Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension. Antioxidants (Basel) 8.
60.
VanWinkle WB, Snuggs M, Miller JC, Buja LM (1994) Cytoskeletal alterations in cultured cardiomyocytes following exposure to the lipid peroxidation product, 4-hydroxynonenal. Cell Motil Cytoskelet 28:119–134CrossRef
61.
62.
Souza-Rabbo MP, Silva LF, Auzani JA, Picoral M, Khaper N, Belló-Klein A (2008) Effects of a chronic exercise training protocol on oxidative stress and right ventricular hypertrophy in monocrotaline-treated rats. Clin Exp Pharmacol Physiol 35:944–948PubMedCrossRef
63.
Hessel MHM, Steendijk P, den Adel B, Schutte CI, van der Laarse A (2006) Characterization of right ventricular function after monocrotaline-inducedpulmonary hypertension in the intact rat. Am J Physiol-Heart and Cir Physiol 291:H2424–H2430CrossRef
64.
Pan LC, Wilson DW, Lame MW, Jones AD, Segall HJ (1993) Cor pulmonale is caused by monocrotaline and dehydromonocrotaline, but not by glutathione or cysteine conjugates of dihydropyrrolizine. Toxicol Appl Pharmacol 118:87–97PubMedCrossRef
65.
Kay JM, Suyama KL, Keane PM (1982) Failure to show decrease in small pulmonary blood vessels in rats with experimental pulmonary hypertension. Thorax 37:927–930PubMedPubMedCentralCrossRef
66.
Christou H, Morita T, Hsieh CM, Koike H, Arkonac B, Perrella MA, Kourembanas S (2000) Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res 86:1224–1229PubMedCrossRef
67.
Adesina SE, Wade BE, Bijli KM, Kang BY, Williams CR, Ma J, Go YM, Hart CM, Sutliff RL (2017) Hypoxia inhibits expression and function of mitochondrial thioredoxin 2 to promote pulmonary hypertension. Am J Physiol-Lung Cellular Mol Physiol 312:L599–L608CrossRef
68.
Pena E, Brito J, Alam SE, Siques P (2020) Oxidative stress, kinase activity and inflammatory implications in right ventricular hypertrophy and heart failure under hypobaric hypoxia. Int J Mol Sci 21:6421PubMedCentralCrossRef
Metadata
Title
Blueberry extract improves redox balance and functional parameters in the right ventricle from rats with pulmonary arterial hypertension
Authors
Patrick Türck
Isadora Schein Salvador
Cristina Campos-Carraro
Vanessa Ortiz
Alan Bahr
Michael Andrades
Adriane Belló-Klein
Alex Sander da Rosa Araujo
Publication date
01-02-2022
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 1/2022
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-021-02642-9

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