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BMC Pulmonary Medicine
Published in: BMC Pulmonary Medicine 1/2020

01-12-2020 | Hypersensitivity Pneumonitis | Case report

Propionibacterium acnes-associated sarcoidosis complicated by acute bird-related hypersensitivity pneumonitis

Authors: Michiru Sawahata, Noritaka Sakamoto, Hideaki Yamasawa, Yuki Iijima, Hirotoshi Kawata, Tetsuo Yamaguchi, Keisuke Uchida, Yoshinobu Eishi, Masashi Bando, Koichi Hagiwara

Published in: BMC Pulmonary Medicine | Issue 1/2020

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Abstract

Background

The number of reports on sarcoidosis complicated by hypersensitivity pneumonitis (HP) is limited, and most describe cases complicated by chronic bird-related HP. Here, we present for the first time a case with Propionibacterium acnes-associated sarcoidosis complicated by acute bird-related HP.

Case presentation

A 62-year-old man with a past medical history of sarcoidosis was admitted to our department, and chest computed tomography showed diffuse ground-glass opacities, which appeared as he rapidly increased the number of pigeons he kept for a competition. Random transbronchial lung biopsy revealed well-formed non-caseating epithelioid granulomas, which contained positively stained substances on immunohistochemistry using the PAB antibody, a specific monoclonal antibody against P. acnes lipoteichoic acid. Poorly formed non-caseating granulomas without positively stained substances were also detected.

Conclusion

We describe the successful identification of this exceptionally rare case of sarcoidosis complicated by acute bird-related HP in which two morphologically and immunohistologically different types of granulomas were present in the same lung.
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Metadata
Title
Propionibacterium acnes-associated sarcoidosis complicated by acute bird-related hypersensitivity pneumonitis
Authors
Michiru Sawahata
Noritaka Sakamoto
Hideaki Yamasawa
Yuki Iijima
Hirotoshi Kawata
Tetsuo Yamaguchi
Keisuke Uchida
Yoshinobu Eishi
Masashi Bando
Koichi Hagiwara
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Pulmonary Medicine / Issue 1/2020
Electronic ISSN: 1471-2466
DOI
https://doi.org/10.1186/s12890-020-01327-z

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