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Published in: Current Pulmonology Reports 4/2019

01-12-2019 | Hypersensitivity Pneumonitis | Interstitial Lung Disease (A Hajari Case, Section Editor)

Hypersensitivity Pneumonitis (Including Environmental Assessment): Diagnosis and Management

Authors: Wing Sun Tam, Tasnim Islam, Anoop M. Nambiar

Published in: Current Pulmonology Reports | Issue 4/2019

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Abstract

Purpose of Review

This article aims to provide an overview on the diagnosis and management of hypersensitivity pneumonitis (HP). We will focus on the issues surrounding the lack of an international consensus on the diagnosis of HP, and review the existing treatment options for HP.

Recent Findings

There is emerging international consensus that HP should be classified based on clinical, radiologic, and pathologic features and not solely on disease duration. Environmental assessment and antigen avoidance remains the most important step in managing HP. Antifibrotics may soon become a viable option for chronic HP in the near future. Well-designed prospective controlled studies are underway.

Summary

Substantial gaps still remain in our understanding of the diagnosis and management of HP. Further research should focus on establishing internationally accepted diagnostic criteria and clinical practice guidelines to aid the clinician in the challenging treatment of patients with HP.
Literature
1.
go back to reference •• Vasakova M, Selman M, Morell F, Sterclova M, Molina-Molina M, Raghu G. Hypersensitivity pneumonitis: current concepts of pathogenesis and potential targets for treatment. Am J Respir Crit Care Medicine. 2019;200:301–8. Important review on our current understanding of HP pathogenesis and potential therapeutic targets for the treatment of HP. •• Vasakova M, Selman M, Morell F, Sterclova M, Molina-Molina M, Raghu G. Hypersensitivity pneumonitis: current concepts of pathogenesis and potential targets for treatment. Am J Respir Crit Care Medicine. 2019;200:301–8. Important review on our current understanding of HP pathogenesis and potential therapeutic targets for the treatment of HP.
2.
go back to reference Pérez ER, Swigris JJ, Forssén AV, Tourin O, Solomon JJ, Huie TJ, et al. Identifying an inciting antigen is associated with improved survival in patients with chronic hypersensitivity pneumonitis. Chest. 2013;144(5):1644–51. Pérez ER, Swigris JJ, Forssén AV, Tourin O, Solomon JJ, Huie TJ, et al. Identifying an inciting antigen is associated with improved survival in patients with chronic hypersensitivity pneumonitis. Chest. 2013;144(5):1644–51.
3.
go back to reference Lacasse Y, Selman M, Costabel U, Dalphin JC, Morell F, Erkinjuntti-Pekkanen R, et al. Classification of hypersensitivity pneumonitis. International archives of allergy and immunology. 2009;149(2):161–6.PubMed Lacasse Y, Selman M, Costabel U, Dalphin JC, Morell F, Erkinjuntti-Pekkanen R, et al. Classification of hypersensitivity pneumonitis. International archives of allergy and immunology. 2009;149(2):161–6.PubMed
4.
go back to reference Zacharisen MC, Schlueter DP, Kurup VP, Fink JN. The long-term outcome in acute, subacute, and chronic forms of pigeon breeder’s disease hypersensitivity pneumonitis. Annals of Allergy, Asthma & Immunology. 2002;88(2):175–82. Zacharisen MC, Schlueter DP, Kurup VP, Fink JN. The long-term outcome in acute, subacute, and chronic forms of pigeon breeder’s disease hypersensitivity pneumonitis. Annals of Allergy, Asthma & Immunology. 2002;88(2):175–82.
5.
go back to reference Ohtani Y, Saiki S, Sumi Y, Inase N, Miyake S, Costabel U, et al. Clinical features of recurrent and insidious chronic bird fancier's lung. Annals of Allergy, Asthma & Immunology. 2003;90(6):604–10. Ohtani Y, Saiki S, Sumi Y, Inase N, Miyake S, Costabel U, et al. Clinical features of recurrent and insidious chronic bird fancier's lung. Annals of Allergy, Asthma & Immunology. 2003;90(6):604–10.
6.
go back to reference Tateishi T, Ohtani Y, Takemura T, Akashi T, Miyazaki Y, Inase N, et al. Serial high-resolution computed tomography findings of acute and chronic hypersensitivity pneumonitis induced by avian antigen. Journal of computer assisted tomography. 2011;35(2):272–9.PubMed Tateishi T, Ohtani Y, Takemura T, Akashi T, Miyazaki Y, Inase N, et al. Serial high-resolution computed tomography findings of acute and chronic hypersensitivity pneumonitis induced by avian antigen. Journal of computer assisted tomography. 2011;35(2):272–9.PubMed
7.
go back to reference •• Vasakova M, Morell F, Walsh S, Leslie K, Raghu G. Hypersensitivity pneumonitis: perspectives in diagnosis and management. American journal of respiratory and critical care medicine. 2017;196(6):680–9. Key review on HP that proposed classification schema for HP as “acute/inflammatory” vs. “chronic/fibrotic”. PubMed •• Vasakova M, Morell F, Walsh S, Leslie K, Raghu G. Hypersensitivity pneumonitis: perspectives in diagnosis and management. American journal of respiratory and critical care medicine. 2017;196(6):680–9. Key review on HP that proposed classification schema for HP as “acute/inflammatory” vs. “chronic/fibrotic”. PubMed
8.
go back to reference •• Salisbury ML, Myers JL, Belloli EA, Kazerooni EA, Martinez FJ, Flaherty KR. Diagnosis and treatment of fibrotic hypersensitivity pneumonia. Where we stand and where we need to go. American journal of respiratory and critical care medicine. 2017;196(6):690–9. Key review on HP. Recommends treating HP according to whether inflammatory features are present or not. PubMedPubMedCentral •• Salisbury ML, Myers JL, Belloli EA, Kazerooni EA, Martinez FJ, Flaherty KR. Diagnosis and treatment of fibrotic hypersensitivity pneumonia. Where we stand and where we need to go. American journal of respiratory and critical care medicine. 2017;196(6):690–9. Key review on HP. Recommends treating HP according to whether inflammatory features are present or not. PubMedPubMedCentral
9.
go back to reference Pérez-Padilla R, Salas J, Chapela R, Sánchez M, Carrillo G, Pérez R, et al. Mortality in Mexican patients with chronic pigeon breeder’s lung compared with those with usual interstitial pneumonia. American Review of Respiratory Disease. 1993;148:49.PubMed Pérez-Padilla R, Salas J, Chapela R, Sánchez M, Carrillo G, Pérez R, et al. Mortality in Mexican patients with chronic pigeon breeder’s lung compared with those with usual interstitial pneumonia. American Review of Respiratory Disease. 1993;148:49.PubMed
10.
go back to reference Ohtani Y, Saiki S, Kitaichi M, Usui Y, Inase N, Costabel U, et al. Chronic bird fancier’s lung: histopathological and clinical correlation. An application of the 2002 ATS/ERS consensus classification of the idiopathic interstitial pneumonias. Thorax. 2005;60(8):665–71.PubMedPubMedCentral Ohtani Y, Saiki S, Kitaichi M, Usui Y, Inase N, Costabel U, et al. Chronic bird fancier’s lung: histopathological and clinical correlation. An application of the 2002 ATS/ERS consensus classification of the idiopathic interstitial pneumonias. Thorax. 2005;60(8):665–71.PubMedPubMedCentral
11.
go back to reference Churg A, Muller NL, Flint J, Wright JL. Chronic hypersensitivity pneumonitis. The American journal of surgical pathology. 2006;30(2):201–8.PubMed Churg A, Muller NL, Flint J, Wright JL. Chronic hypersensitivity pneumonitis. The American journal of surgical pathology. 2006;30(2):201–8.PubMed
12.
go back to reference Chiba S, Tsuchiya K, Akashi T, Ishizuka M, Okamoto T, Furusawa H, et al. Chronic hypersensitivity pneumonitis with a usual interstitial pneumonia-like pattern: correlation between histopathologic and clinical findings. Chest. 2016;149(6):1473–81.PubMed Chiba S, Tsuchiya K, Akashi T, Ishizuka M, Okamoto T, Furusawa H, et al. Chronic hypersensitivity pneumonitis with a usual interstitial pneumonia-like pattern: correlation between histopathologic and clinical findings. Chest. 2016;149(6):1473–81.PubMed
13.
go back to reference Vourlekis JS, Schwarz MI, Cherniack RM, Curran-Everett D, Cool CD, Tuder RM, et al. The effect of pulmonary fibrosis on survival in patients with hypersensitivity pneumonitis. The American journal of medicine. 2004;116(10):662–8.PubMed Vourlekis JS, Schwarz MI, Cherniack RM, Curran-Everett D, Cool CD, Tuder RM, et al. The effect of pulmonary fibrosis on survival in patients with hypersensitivity pneumonitis. The American journal of medicine. 2004;116(10):662–8.PubMed
14.
go back to reference Pérez F, Evans R, et al. Epidemiology of hypersensitivity pneumonitis among an insured population in the United States: a claims-based cohort analysis. Annals of the American Thoracic Society. 2018;15.4:460–9. Pérez F, Evans R, et al. Epidemiology of hypersensitivity pneumonitis among an insured population in the United States: a claims-based cohort analysis. Annals of the American Thoracic Society. 2018;15.4:460–9.
16.
go back to reference Nogueira R, Melo N, e Bastos HN, Martins N, Delgado L, Morais A, et al. Hypersensitivity pneumonitis: antigen diversity and disease implications. Pulmonology. 2019;25(2):97–108.PubMed Nogueira R, Melo N, e Bastos HN, Martins N, Delgado L, Morais A, et al. Hypersensitivity pneumonitis: antigen diversity and disease implications. Pulmonology. 2019;25(2):97–108.PubMed
18.
go back to reference Bourke SJ, Dalphin JC, Boyd G, McSharry C, Baldwin CI, Calvert JE. Hypersensitivity pneumonitis: current concepts. European Respiratory Journal. 2001;18(32 suppl):81s–92s. Bourke SJ, Dalphin JC, Boyd G, McSharry C, Baldwin CI, Calvert JE. Hypersensitivity pneumonitis: current concepts. European Respiratory Journal. 2001;18(32 suppl):81s–92s.
19.
go back to reference Reich JM. Chirping rales in bird-fancier’s lung. Chest. 1993;104(1):326–7.PubMed Reich JM. Chirping rales in bird-fancier’s lung. Chest. 1993;104(1):326–7.PubMed
20.
go back to reference Fenoglio CM, Reboux G, Sudre B, Mercier M, Roussel S, Cordier JF, et al. Diagnostic value of serum precipitins to mould antigens in active hypersensitivity pneumonitis. European Respiratory Journal. 2007;29(4):706–12.PubMed Fenoglio CM, Reboux G, Sudre B, Mercier M, Roussel S, Cordier JF, et al. Diagnostic value of serum precipitins to mould antigens in active hypersensitivity pneumonitis. European Respiratory Journal. 2007;29(4):706–12.PubMed
21.
go back to reference Van Hoeyveld E, Dupont L, Bossuyt X. Quantification of IgG antibodies to Aspergillus fumigatus and pigeon antigens by ImmunoCAP technology: an alternative to the precipitation technique? Clinical chemistry. 2006;52(9):1785–93.PubMed Van Hoeyveld E, Dupont L, Bossuyt X. Quantification of IgG antibodies to Aspergillus fumigatus and pigeon antigens by ImmunoCAP technology: an alternative to the precipitation technique? Clinical chemistry. 2006;52(9):1785–93.PubMed
22.
go back to reference Raulf M, Joest M, Sander I, Hoffmeyer F, Nowak D, Ochmann U, Preisser A, Schreiber J, Sennekamp J, Koschel D. Update of reference values for IgG antibodies against typical antigens of hypersensitivity pneumonitis. Allergo J Int. 2019;1–2. Raulf M, Joest M, Sander I, Hoffmeyer F, Nowak D, Ochmann U, Preisser A, Schreiber J, Sennekamp J, Koschel D. Update of reference values for IgG antibodies against typical antigens of hypersensitivity pneumonitis. Allergo J Int. 2019;1–2.
23.
go back to reference Lynch DA, Newell JD, Logan PM, King TE Jr, Müller NL. Can CT distinguish hypersensitivity pneumonitis from idiopathic pulmonary fibrosis?. AJR. American journal of roentgenology. 1995;165(4):807–11.PubMed Lynch DA, Newell JD, Logan PM, King TE Jr, Müller NL. Can CT distinguish hypersensitivity pneumonitis from idiopathic pulmonary fibrosis?. AJR. American journal of roentgenology. 1995;165(4):807–11.PubMed
24.
go back to reference Silva CI, Muller NL, Lynch DA, Curran-Everett D, Brown KK, Lee KS, et al. Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT. Radiology. 2008;246(1):288–97.PubMed Silva CI, Muller NL, Lynch DA, Curran-Everett D, Brown KK, Lee KS, et al. Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT. Radiology. 2008;246(1):288–97.PubMed
25.
go back to reference Hansell DM, Wells AU, Padley SP, Müller NL. Hypersensitivity pneumonitis: correlation of individual CT patterns with functional abnormalities. Radiology. 1996;199(1):123–8.PubMed Hansell DM, Wells AU, Padley SP, Müller NL. Hypersensitivity pneumonitis: correlation of individual CT patterns with functional abnormalities. Radiology. 1996;199(1):123–8.PubMed
26.
go back to reference Lynch DA, Rose CS. Way D, King Jr TE. Hypersensitivity pneumonitis: sensitivity of high-resolution CT in a population-based study. AJR. American journal of roentgenology. 1992;159(3):469–72.PubMed Lynch DA, Rose CS. Way D, King Jr TE. Hypersensitivity pneumonitis: sensitivity of high-resolution CT in a population-based study. AJR. American journal of roentgenology. 1992;159(3):469–72.PubMed
27.
go back to reference Silva CI, Churg A, Müller NL. Hypersensitivity pneumonitis: spectrum of high-resolution CT and pathologic findings. American Journal of Roentgenology. 2007;188(2):334–44.PubMed Silva CI, Churg A, Müller NL. Hypersensitivity pneumonitis: spectrum of high-resolution CT and pathologic findings. American Journal of Roentgenology. 2007;188(2):334–44.PubMed
28.
go back to reference Sahin H, Brown KK, Curran-Everett D, Hale V, Cool CD, Vourlekis JS, et al. Chronic hypersensitivity pneumonitis: CT features—comparison with pathologic evidence of fibrosis and survival. Radiology. 2007;244(2):591–8.PubMed Sahin H, Brown KK, Curran-Everett D, Hale V, Cool CD, Vourlekis JS, et al. Chronic hypersensitivity pneumonitis: CT features—comparison with pathologic evidence of fibrosis and survival. Radiology. 2007;244(2):591–8.PubMed
29.
go back to reference Chung JH, Zhan X, Cao M, Koelsch TL, Manjarres DC, Brown KK, et al. Presence of air trapping and mosaic attenuation on chest computed tomography predicts survival in chronic hypersensitivity pneumonitis. Annals of the American Thoracic Society. 2017;14(10):1533–8.PubMed Chung JH, Zhan X, Cao M, Koelsch TL, Manjarres DC, Brown KK, et al. Presence of air trapping and mosaic attenuation on chest computed tomography predicts survival in chronic hypersensitivity pneumonitis. Annals of the American Thoracic Society. 2017;14(10):1533–8.PubMed
30.
go back to reference • Barnett J, Molyneaux PL, Rawal B, Abdullah R, Hare SS, Vancheeswaran R, et al. Variable utility of mosaic attenuation to distinguish fibrotic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis. European Respiratory Journal. 2019;54(1):1900531. Interesting study that noted the presence of mosaic attenuation in 51% of IPF patients and found the “headcheese sign” to be a highly specific radiologic finding for fibrotic HP. PubMed • Barnett J, Molyneaux PL, Rawal B, Abdullah R, Hare SS, Vancheeswaran R, et al. Variable utility of mosaic attenuation to distinguish fibrotic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis. European Respiratory Journal. 2019;54(1):1900531. Interesting study that noted the presence of mosaic attenuation in 51% of IPF patients and found the “headcheese sign” to be a highly specific radiologic finding for fibrotic HP. PubMed
31.
go back to reference Aburto M, Herráez I, Iturbe D, Jiménez-Romero A. Diagnosis of idiopathic pulmonary fibrosis: differential diagnosis. Medical Sciences. 2018;6(3):73.PubMedCentral Aburto M, Herráez I, Iturbe D, Jiménez-Romero A. Diagnosis of idiopathic pulmonary fibrosis: differential diagnosis. Medical Sciences. 2018;6(3):73.PubMedCentral
32.
go back to reference Ohshimo S, Bonella F, Cui A, Beume M, Kohno N, Guzman J, et al. Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis. American journal of respiratory and critical care medicine. 2009;179(11):1043–7.PubMed Ohshimo S, Bonella F, Cui A, Beume M, Kohno N, Guzman J, et al. Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis. American journal of respiratory and critical care medicine. 2009;179(11):1043–7.PubMed
33.
go back to reference • Morisset J, Johannson KA, Jones KD, Wolters PJ, Collard HR, Walsh SL, et al. Identification of diagnostic criteria for chronic hypersensitivity pneumonitis. An International Modified Delphi Survey. American journal of respiratory and critical care medicine. 2018;197(8):1036–44. Recent Delphi survey among international HP experts on consensus diagnostic features of chronic HP. PubMedPubMedCentral • Morisset J, Johannson KA, Jones KD, Wolters PJ, Collard HR, Walsh SL, et al. Identification of diagnostic criteria for chronic hypersensitivity pneumonitis. An International Modified Delphi Survey. American journal of respiratory and critical care medicine. 2018;197(8):1036–44. Recent Delphi survey among international HP experts on consensus diagnostic features of chronic HP. PubMedPubMedCentral
34.
go back to reference Meyer KC, Raghu G, Baughman RP, Brown KK, Costabel U, du Bois RM, et al. An official American Thoracic Society clinical practice guideline: the clinical utility of bronchoalveolar lavage cellular analysis in interstitial lung disease. American journal of respiratory and critical care medicine. 2012;185(9):1004–14.PubMed Meyer KC, Raghu G, Baughman RP, Brown KK, Costabel U, du Bois RM, et al. An official American Thoracic Society clinical practice guideline: the clinical utility of bronchoalveolar lavage cellular analysis in interstitial lung disease. American journal of respiratory and critical care medicine. 2012;185(9):1004–14.PubMed
35.
go back to reference • Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ, et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline. American journal of respiratory and critical care medicine. 2018;198(5):e44–68. Most recent IPF clinical practice guidelines for the diagnosis of IPF. PubMed • Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ, et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline. American journal of respiratory and critical care medicine. 2018;198(5):e44–68. Most recent IPF clinical practice guidelines for the diagnosis of IPF. PubMed
36.
go back to reference Adams TN, Newton CA, Batra K, Abu-Hijleh M, Barbera T, Torrealba J, et al. Utility of bronchoalveolar lavage and transbronchial biopsy in patients with hypersensitivity pneumonitis. Lung. 2018;196(5):617–22.PubMedPubMedCentral Adams TN, Newton CA, Batra K, Abu-Hijleh M, Barbera T, Torrealba J, et al. Utility of bronchoalveolar lavage and transbronchial biopsy in patients with hypersensitivity pneumonitis. Lung. 2018;196(5):617–22.PubMedPubMedCentral
37.
go back to reference Trahan S, Hanak V, Ryu JH, Myers JL. Role of surgical lung biopsy in separating chronic hypersensitivity pneumonia from usual interstitial pneumonia/idiopathic pulmonary fibrosis*: analysis of 31 biopsies from 15 patients. Chest. 2008;134(1):126–32.PubMed Trahan S, Hanak V, Ryu JH, Myers JL. Role of surgical lung biopsy in separating chronic hypersensitivity pneumonia from usual interstitial pneumonia/idiopathic pulmonary fibrosis*: analysis of 31 biopsies from 15 patients. Chest. 2008;134(1):126–32.PubMed
38.
go back to reference Sharp C, McCabe M, Adamali H, Medford AR. Use of transbronchial cryobiopsy in the diagnosis of interstitial lung disease—a systematic review and cost analysis. QJM: An International Journal of Medicine. 2016;110(4):207–14. Sharp C, McCabe M, Adamali H, Medford AR. Use of transbronchial cryobiopsy in the diagnosis of interstitial lung disease—a systematic review and cost analysis. QJM: An International Journal of Medicine. 2016;110(4):207–14.
39.
go back to reference Takemura T, Akashi T, Ohtani Y, Inase N, Yoshizawa Y. Pathology of hypersensitivity pneumonitis. Curr Opin Pulm Med. 2008;14(5):440–54.PubMed Takemura T, Akashi T, Ohtani Y, Inase N, Yoshizawa Y. Pathology of hypersensitivity pneumonitis. Curr Opin Pulm Med. 2008;14(5):440–54.PubMed
40.
go back to reference Churg A, Sin DD, Everett D, Brown K, Cool C. Pathologic patterns and survival in chronic hypersensitivity pneumonitis. Am J Surg Pathol. 2009;33:1765–70.PubMed Churg A, Sin DD, Everett D, Brown K, Cool C. Pathologic patterns and survival in chronic hypersensitivity pneumonitis. Am J Surg Pathol. 2009;33:1765–70.PubMed
41.
go back to reference Ohtani Y, Kojima K, Sumi Y, Sawada M, Inase N, Miyake S, et al. Inhalation provocation tests in chronic bird fancier’s lung. Chest. 2000;118:1382–9.PubMed Ohtani Y, Kojima K, Sumi Y, Sawada M, Inase N, Miyake S, et al. Inhalation provocation tests in chronic bird fancier’s lung. Chest. 2000;118:1382–9.PubMed
42.
go back to reference Walsh SL, Sverzellati N, Devaraj A, Wells AU, Hansell DM. Chronic hypersensitivity pneumonitis: high resolution computed tomography patterns and pulmonary function indices as prognostic determinants. European radiology. 2012;22(8):1672–9.PubMed Walsh SL, Sverzellati N, Devaraj A, Wells AU, Hansell DM. Chronic hypersensitivity pneumonitis: high resolution computed tomography patterns and pulmonary function indices as prognostic determinants. European radiology. 2012;22(8):1672–9.PubMed
43.
go back to reference Morell F, Villar A, Montero MÁ, Muñoz X, Colby TV, Pipvath S, et al. Chronic hypersensitivity pneumonitis in patients diagnosed with idiopathic pulmonary fibrosis: a prospective case-cohort study. The lancet Respiratory medicine. 2013;1(9):685–94.PubMed Morell F, Villar A, Montero MÁ, Muñoz X, Colby TV, Pipvath S, et al. Chronic hypersensitivity pneumonitis in patients diagnosed with idiopathic pulmonary fibrosis: a prospective case-cohort study. The lancet Respiratory medicine. 2013;1(9):685–94.PubMed
44.
go back to reference • Ryerson CJ, Corte TJ, Lee JS, Richeldi L, Walsh SL, Myers JL, et al. A standardized diagnostic ontology for fibrotic interstitial lung disease. An international working group perspective. American journal of respiratory and critical care medicine. 2017;196(10):1249–54. Provides a framework for the standardization of diagnostic confidence in ILD. PubMedPubMedCentral • Ryerson CJ, Corte TJ, Lee JS, Richeldi L, Walsh SL, Myers JL, et al. A standardized diagnostic ontology for fibrotic interstitial lung disease. An international working group perspective. American journal of respiratory and critical care medicine. 2017;196(10):1249–54. Provides a framework for the standardization of diagnostic confidence in ILD. PubMedPubMedCentral
45.
go back to reference Elicker BM, Jones KD, Henry TS, Collard HR. Multidisciplinary approach to hypersensitivity pneumonitis. Journal of thoracic imaging. 2016;31(2):92–103.PubMed Elicker BM, Jones KD, Henry TS, Collard HR. Multidisciplinary approach to hypersensitivity pneumonitis. Journal of thoracic imaging. 2016;31(2):92–103.PubMed
46.
go back to reference Sema M, Miyazaki Y, Tsutsui T, Tomita M, Eishi Y, Inase N. Environmental levels of avian antigen are relevant to the progression of chronic hypersensitivity pneumonitis during antigen avoidance. Immunity, inflammation and disease. 2018;6(1):154–62.PubMed Sema M, Miyazaki Y, Tsutsui T, Tomita M, Eishi Y, Inase N. Environmental levels of avian antigen are relevant to the progression of chronic hypersensitivity pneumonitis during antigen avoidance. Immunity, inflammation and disease. 2018;6(1):154–62.PubMed
47.
go back to reference De Gracia J, Morell F, Bofill JM, Curull V, Orriols R. Time of exposure as a prognostic factor in avian hypersensitivity pneumonitis. Respiratory medicine. 1989;83(2):139–43.PubMed De Gracia J, Morell F, Bofill JM, Curull V, Orriols R. Time of exposure as a prognostic factor in avian hypersensitivity pneumonitis. Respiratory medicine. 1989;83(2):139–43.PubMed
48.
go back to reference Quirce S, Vandenplas O, Campo P, Cruz MJ, de Blay F, Koschel D, et al. Occupational hypersensitivity pneumonitis: an EAACI position paper. Allergy. 2016;71(6):765–79. Quirce S, Vandenplas O, Campo P, Cruz MJ, de Blay F, Koschel D, et al. Occupational hypersensitivity pneumonitis: an EAACI position paper. Allergy. 2016;71(6):765–79.
49.
go back to reference Millerick-May ML, Mulks MH, Gerlach J, Flaherty KR, Schmidt SL, Martinez FJ, et al. Hypersensitivity pneumonitis and antigen identification–an alternate approach. Respiratory medicine. 2016;112:97–105.PubMed Millerick-May ML, Mulks MH, Gerlach J, Flaherty KR, Schmidt SL, Martinez FJ, et al. Hypersensitivity pneumonitis and antigen identification–an alternate approach. Respiratory medicine. 2016;112:97–105.PubMed
50.
go back to reference Craig TJ, Hershey J, Engler RJ, Davis W, Carpenter GB, Salata K. Bird antigen persistence in the home environment after removal of the bird. Annals of allergy. 1992;69(6):510–2.PubMed Craig TJ, Hershey J, Engler RJ, Davis W, Carpenter GB, Salata K. Bird antigen persistence in the home environment after removal of the bird. Annals of allergy. 1992;69(6):510–2.PubMed
51.
go back to reference Ohshimo S, Bonella F, Guzman J, Costabel U. Hypersensitivity pneumonitis. Immunology and Allergy Clinics. 2012;32(4):537–56. Ohshimo S, Bonella F, Guzman J, Costabel U. Hypersensitivity pneumonitis. Immunology and Allergy Clinics. 2012;32(4):537–56.
52.
go back to reference Kokkarinen JI, Tukiainen HO, Terho EO. Effect of corticosteroid treatment on the recovery of pulmonary function in farmer’s lung 1-3. Am Rev Respir Dis. 1992;145:3–5.PubMed Kokkarinen JI, Tukiainen HO, Terho EO. Effect of corticosteroid treatment on the recovery of pulmonary function in farmer’s lung 1-3. Am Rev Respir Dis. 1992;145:3–5.PubMed
53.
go back to reference Mönkäre S. Influence of corticosteroid treatment on the course of farmer’s lung. European journal of respiratory diseases. 1983;64(4):283–93.PubMed Mönkäre S. Influence of corticosteroid treatment on the course of farmer’s lung. European journal of respiratory diseases. 1983;64(4):283–93.PubMed
54.
go back to reference De Sadeleer L, Hermans F, De Dycker E, Yserbyt J, Verschakelen J, Verbeken E, et al. Effects of corticosteroid treatment and antigen avoidance in a large hypersensitivity pneumonitis cohort: a single-centre cohort study. Journal of clinical medicine. 2019;8(1):14. De Sadeleer L, Hermans F, De Dycker E, Yserbyt J, Verschakelen J, Verbeken E, et al. Effects of corticosteroid treatment and antigen avoidance in a large hypersensitivity pneumonitis cohort: a single-centre cohort study. Journal of clinical medicine. 2019;8(1):14.
55.
go back to reference Morisset J, Johannson KA, Vittinghoff E, Aravena C, Elicker BM, Jones KD, et al. Use of mycophenolate mofetil or azathioprine for the management of chronic hypersensitivity pneumonitis. Chest. 2017;151(3):619–25.PubMed Morisset J, Johannson KA, Vittinghoff E, Aravena C, Elicker BM, Jones KD, et al. Use of mycophenolate mofetil or azathioprine for the management of chronic hypersensitivity pneumonitis. Chest. 2017;151(3):619–25.PubMed
56.
go back to reference Adegunsoye A, Oldham JM, Pérez ER, Hamblin M, Patel N, Tener M, et al. Outcomes of immunosuppressive therapy in chronic hypersensitivity pneumonitis. ERJ open research. 2017;3(3):00016–2017.PubMedPubMedCentral Adegunsoye A, Oldham JM, Pérez ER, Hamblin M, Patel N, Tener M, et al. Outcomes of immunosuppressive therapy in chronic hypersensitivity pneumonitis. ERJ open research. 2017;3(3):00016–2017.PubMedPubMedCentral
57.
go back to reference Keir GJ, Maher TM, Ming D, Abdullah R, de Lauretis A, Wickremasinghe M, et al. Rituximab in severe, treatment-refractory interstitial lung disease. Respirology. 2014 Apr;19(3):353–9.PubMed Keir GJ, Maher TM, Ming D, Abdullah R, de Lauretis A, Wickremasinghe M, et al. Rituximab in severe, treatment-refractory interstitial lung disease. Respirology. 2014 Apr;19(3):353–9.PubMed
58.
go back to reference Cottin V, Hirani NA, Hotchkin DL, Nambiar AM, et al. Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases. Eur Respir Rev. 2018;27:180076.PubMed Cottin V, Hirani NA, Hotchkin DL, Nambiar AM, et al. Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases. Eur Respir Rev. 2018;27:180076.PubMed
59.
go back to reference Shibata S, Furusawa H, Inase N. Pirfenidone in chronic hypersensitivity pneumonitis: a real-life experience. Sarcoidosis vasculitis and diffuse lung disease. 2018;35(2):139–42. Shibata S, Furusawa H, Inase N. Pirfenidone in chronic hypersensitivity pneumonitis: a real-life experience. Sarcoidosis vasculitis and diffuse lung disease. 2018;35(2):139–42.
60.
go back to reference Behr J, Neuser P, Prasse A, Kreuter M, Rabe K, Schade-Brittinger C, et al. Exploring efficacy and safety of oral pirfenidone for progressive, non-IPF lung fibrosis (RELIEF): a randomized, double-blind, placebo-controlled, parallel group, multi-center, phase II trial. BMC Pulm Med. 2017;17:122.PubMedPubMedCentral Behr J, Neuser P, Prasse A, Kreuter M, Rabe K, Schade-Brittinger C, et al. Exploring efficacy and safety of oral pirfenidone for progressive, non-IPF lung fibrosis (RELIEF): a randomized, double-blind, placebo-controlled, parallel group, multi-center, phase II trial. BMC Pulm Med. 2017;17:122.PubMedPubMedCentral
61.
go back to reference Flaherty KR, Brown KK, Wells AU, Clerisme-Beaty E, Collard HR, Cottin V, et al. Design of the PF-ILD trial: a double-blind, randomised, placebo-controlled phase III trial of nintedanib in patients with progressive fibrosing interstitial lung disease. BMJ open respiratory research. 2017;4(1):e000212.PubMedPubMedCentral Flaherty KR, Brown KK, Wells AU, Clerisme-Beaty E, Collard HR, Cottin V, et al. Design of the PF-ILD trial: a double-blind, randomised, placebo-controlled phase III trial of nintedanib in patients with progressive fibrosing interstitial lung disease. BMJ open respiratory research. 2017;4(1):e000212.PubMedPubMedCentral
62.
go back to reference Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, et al. Lung transplantation for hypersensitivity pneumonitis. Chest. 2015;147(6):1558–65.PubMed Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, et al. Lung transplantation for hypersensitivity pneumonitis. Chest. 2015;147(6):1558–65.PubMed
63.
go back to reference Sansores R, Salas J, Chapela R, Barquin N, Selman M. Clubbing in hypersensitivity pneumonitis: its prevalence and possible prognostic role. Archives of internal medicine. 1990;150(9):1849–51.PubMed Sansores R, Salas J, Chapela R, Barquin N, Selman M. Clubbing in hypersensitivity pneumonitis: its prevalence and possible prognostic role. Archives of internal medicine. 1990;150(9):1849–51.PubMed
64.
go back to reference Gimenez A, Storrer K, Kuranishi L, Soares MR, Ferreira RG, Pereira CA. Change in FVC and survival in chronic fibrotic hypersensitivity pneumonitis. Thorax. 2018;73(4):391–2.PubMed Gimenez A, Storrer K, Kuranishi L, Soares MR, Ferreira RG, Pereira CA. Change in FVC and survival in chronic fibrotic hypersensitivity pneumonitis. Thorax. 2018;73(4):391–2.PubMed
65.
go back to reference Miyazaki Y, Tateishi T, Akashi T, Ohtani Y, Inase N, Yoshizawa Y. Clinical predictors and histologic appearance of acute exacerbations in chronic hypersensitivity pneumonitis. Chest. 2008;134(6):1265–70.PubMed Miyazaki Y, Tateishi T, Akashi T, Ohtani Y, Inase N, Yoshizawa Y. Clinical predictors and histologic appearance of acute exacerbations in chronic hypersensitivity pneumonitis. Chest. 2008;134(6):1265–70.PubMed
66.
go back to reference Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, et al. Predicting survival across chronic interstitial lung disease: the ILD-GAP model. Chest. 2014;145(4):723–8.PubMed Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, et al. Predicting survival across chronic interstitial lung disease: the ILD-GAP model. Chest. 2014;145(4):723–8.PubMed
67.
go back to reference Mooney JJ, Elicker BM, Urbania TH, Agarwal MR, Ryerson CJ, Nguyen ML, et al. Radiographic fibrosis score predicts survival in hypersensitivity pneumonitis. Chest. 2013;144(2):586–92.PubMed Mooney JJ, Elicker BM, Urbania TH, Agarwal MR, Ryerson CJ, Nguyen ML, et al. Radiographic fibrosis score predicts survival in hypersensitivity pneumonitis. Chest. 2013;144(2):586–92.PubMed
68.
go back to reference Hanak V, Golbin JM, Hartman TE, Ryu JH. High-resolution CT findings of parenchymal fibrosis correlate with prognosis in hypersensitivity pneumonitis. Chest. 2008;134(1):133–8.PubMed Hanak V, Golbin JM, Hartman TE, Ryu JH. High-resolution CT findings of parenchymal fibrosis correlate with prognosis in hypersensitivity pneumonitis. Chest. 2008;134(1):133–8.PubMed
69.
go back to reference • Salisbury ML, Gu T, Murray S, Gross BH, Chughtai A, Sayyouh M, et al. Hypersensitivity pneumonitis: radiologic phenotypes are associated with distinct survival time and pulmonary function trajectory. Chest. 2019;155(4):699–711. Recent paper on classifying HRCT findings of HP patients into three phenotypes. PubMed • Salisbury ML, Gu T, Murray S, Gross BH, Chughtai A, Sayyouh M, et al. Hypersensitivity pneumonitis: radiologic phenotypes are associated with distinct survival time and pulmonary function trajectory. Chest. 2019;155(4):699–711. Recent paper on classifying HRCT findings of HP patients into three phenotypes. PubMed
70.
go back to reference Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, et al. Pathologic findings and prognosis in a large prospective cohort of chronic hypersensitivity pneumonitis. Chest. 2017;152(3):502–9.PubMed Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, et al. Pathologic findings and prognosis in a large prospective cohort of chronic hypersensitivity pneumonitis. Chest. 2017;152(3):502–9.PubMed
71.
go back to reference Nukui Y, Miyazaki Y, Masuo M, Okamoto T, Furusawa H, Tateishi T, Kishino M, Tateishi U, Ono J, Ohta S, Izuhara K. Periostin as a predictor of prognosis in chronic bird-related hypersensitivity pneumonitis. Allergology International. 2019. Nukui Y, Miyazaki Y, Masuo M, Okamoto T, Furusawa H, Tateishi T, Kishino M, Tateishi U, Ono J, Ohta S, Izuhara K. Periostin as a predictor of prognosis in chronic bird-related hypersensitivity pneumonitis. Allergology International. 2019.
Metadata
Title
Hypersensitivity Pneumonitis (Including Environmental Assessment): Diagnosis and Management
Authors
Wing Sun Tam
Tasnim Islam
Anoop M. Nambiar
Publication date
01-12-2019
Publisher
Springer US
Published in
Current Pulmonology Reports / Issue 4/2019
Electronic ISSN: 2199-2428
DOI
https://doi.org/10.1007/s13665-019-00239-6

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