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Critical Care
Published in: Critical Care 1/2011

Open Access 01-02-2011 | Poster presentation

Hypercapnic acidosis transiently weakens hypoxic pulmonary vasoconstriction in anesthetized pigs, without affecting the endogenous pulmonary nitric oxide production

Authors: MC Nilsson, A Larsson, K Hambraeus-Jonzon

Published in: Critical Care | Special Issue 1/2011

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Excerpt

Hypercapnic acidosis is often seen in critically ill patients and during protective mechanical ventilation. Conflicting findings regarding the effect of hypercapnic acidosis on endogenous nitric oxide (NO) production and hypoxic pulmonary vasoconstriction (HPV) have been reported. The aim of this study was to test the effects of hypercapnic acidosis on HPV, and the endogenous NO production in hypoxic and hyperoxic lung regions. …
Literature
1.
Ketabchi F, et al.: Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 2009, 297: L977-L983.CrossRefPubMed
2.
Pfeiffer B, et al.: Mechanical ventilation with permissive hypercapnia increases intrapulmonary shunt in septic and nonseptic patients with acute respiratory distress syndrome. Crit Care Med 2002, 30: 285-289.CrossRefPubMed
Metadata
Title
Hypercapnic acidosis transiently weakens hypoxic pulmonary vasoconstriction in anesthetized pigs, without affecting the endogenous pulmonary nitric oxide production
Authors
MC Nilsson
A Larsson
K Hambraeus-Jonzon
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9601

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