Published in:
Open Access
01-02-2011 | Poster presentation
Hemodynamic effects of early endotoxemia on pulse pressure variation during experimental hemorrhagic shock
Authors:
J Noel-Morgan, DT Fantoni, DA Otsuki, JO Auler Jr
Published in:
Critical Care
|
Special Issue 1/2011
Login to get access
Excerpt
Although pulse pressure variation (PPV) is essentially proposed as a predictor of fluid responsiveness [
1], it has also been appointed as an early detector of hypovolemia [
2]. Still, caution has been recommended for its employment in certain conditions, as during pulmonary hypertension (PH) [
2,
3]. Endotoxin-induced PH produces biphasic increase in mean pulmonary artery pressure (MPAP) in several animal models, in which the early phase is acute and transient [
4]. The objective of this study was to analyze the early hemodynamic effects of endotoxemia on PPV, during severe hypovolemic shock. …